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Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss.
Ann Hematol. 2007 Jan; 86(1):35-40.AH

Abstract

Hyperhomocysteinemia (HHC) is a known risk factor for venous and arterial thrombosis. Thrombophilia workup includes the level of homocysteine and other related parameters such as: vitamin B(12), folic acid, and methylenetetrahydrofolate reductase (MTHFR) C677T genotype. As the levels of homocysteine, vitamin B(12), folic acid, and MTHFR C677T genotype are linked biochemically, we hypothesized that a statistical association will be found between them. The purpose of the present study was to assess the association between the four parameters in patients with a thrombotic event or recurrent fetal loss. The potential study population included 326 patients who were referred to the Thrombosis and Hemostasis Unit; 125 of these patients had at least one pathological test result of the four parameters. The correlations between homocysteine and vitamin B(12) as well as between homocysteine and folic acid were found to be weak (r = -0.236 and r = -0.209, respectively). No significant difference was revealed between the mean homocysteine level and the CC, CT, and TT MTHFR genotypes (p = 0.246). In conclusion, in the population studied, the association between homocysteine, vitamin B(12), folic acid, and MTHFR C677T is weak. The results raise doubt as to whether the current routine evaluation of HHC, as part of thrombophilia workup, truly reflects the increased risk of thrombosis.

Authors+Show Affiliations

Thrombosis and Hemostasis Unit, Department of Hematology, Rambam Medical Center, Haifa, Israel. ynadir@netvision.net.ilNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17043779

Citation

Nadir, Y, et al. "Association of Homocysteine, Vitamin B12, Folic Acid, and MTHFR C677T in Patients With a Thrombotic Event or Recurrent Fetal Loss." Annals of Hematology, vol. 86, no. 1, 2007, pp. 35-40.
Nadir Y, Hoffman R, Brenner B. Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss. Ann Hematol. 2007;86(1):35-40.
Nadir, Y., Hoffman, R., & Brenner, B. (2007). Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss. Annals of Hematology, 86(1), 35-40.
Nadir Y, Hoffman R, Brenner B. Association of Homocysteine, Vitamin B12, Folic Acid, and MTHFR C677T in Patients With a Thrombotic Event or Recurrent Fetal Loss. Ann Hematol. 2007;86(1):35-40. PubMed PMID: 17043779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss. AU - Nadir,Y, AU - Hoffman,R, AU - Brenner,B, Y1 - 2006/10/17/ PY - 2006/08/28/received PY - 2006/09/02/accepted PY - 2006/10/18/pubmed PY - 2007/10/4/medline PY - 2006/10/18/entrez SP - 35 EP - 40 JF - Annals of hematology JO - Ann Hematol VL - 86 IS - 1 N2 - Hyperhomocysteinemia (HHC) is a known risk factor for venous and arterial thrombosis. Thrombophilia workup includes the level of homocysteine and other related parameters such as: vitamin B(12), folic acid, and methylenetetrahydrofolate reductase (MTHFR) C677T genotype. As the levels of homocysteine, vitamin B(12), folic acid, and MTHFR C677T genotype are linked biochemically, we hypothesized that a statistical association will be found between them. The purpose of the present study was to assess the association between the four parameters in patients with a thrombotic event or recurrent fetal loss. The potential study population included 326 patients who were referred to the Thrombosis and Hemostasis Unit; 125 of these patients had at least one pathological test result of the four parameters. The correlations between homocysteine and vitamin B(12) as well as between homocysteine and folic acid were found to be weak (r = -0.236 and r = -0.209, respectively). No significant difference was revealed between the mean homocysteine level and the CC, CT, and TT MTHFR genotypes (p = 0.246). In conclusion, in the population studied, the association between homocysteine, vitamin B(12), folic acid, and MTHFR C677T is weak. The results raise doubt as to whether the current routine evaluation of HHC, as part of thrombophilia workup, truly reflects the increased risk of thrombosis. SN - 1432-0584 UR - https://www.unboundmedicine.com/medline/citation/17043779/Association_of_homocysteine_vitamin_B12_folic_acid_and_MTHFR_C677T_in_patients_with_a_thrombotic_event_or_recurrent_fetal_loss_ L2 - https://dx.doi.org/10.1007/s00277-006-0194-1 DB - PRIME DP - Unbound Medicine ER -