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[Effects of glucagon-like peptide 2 on the adaptation of residual small bowel in a rat model of short bowel syndrome].
Zhonghua Wei Chang Wai Ke Za Zhi. 2006 Sep; 9(5):441-4.ZW

Abstract

OBJECTIVE

To investigate the effects of glucagon-like peptide 2 (GLP-2) on the morphology and functional adaptation of the residual small bowel in rat model of short bowel syndrome.

METHODS

Twenty rats with 75% of the midjejunoileum removed were randomly divided into two groups, and received intra-peritoneal injection of GLP-2(250 micro*gd*kg-1*d-1) or subcutaneous injection saline(0.5 ml, twice one day) after operation. On postoperative day 6, the morphological changes of the residual jejunum and ileum, the expression of proliferating cell nuclear antigen(PCNA), and the mRNA expressions of Na-D-glucose cotransporters (SGLT1) and peptide cotransporters (PEPT1) were determined. The intestinal glucose absorption data per unit length as well as per unit weight of ileum were measured by in vivo circulatory perfusion experiment.

RESULTS

The morphological parameters of the residual gut such as the thickness of mucosa, height of villus, depth of crypt, and PCNA positive index were significantly higher, while the apoptosis rate per unit of mucosal square was significantly lower in GLP-2 treatment group than those in the control group. The expressions of mRNA SGTLl and PEPT1 in the residual ileum were significantly higher than those in the control group. There was no significant difference in glucose absorption rate per gram of mucosal wet weight between the two groups (P > 0.05).

CONCLUSION

GLP-2 could improve morphological and functional adaptation of the residual small bowel by stimulating enterocyte proliferation and decreasing enterocyte apoptosis in short bowel syndrome.

Authors+Show Affiliations

Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. prowugh@yahoo.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17043970

Citation

Wu, Guo-Hao, et al. "[Effects of Glucagon-like Peptide 2 On the Adaptation of Residual Small Bowel in a Rat Model of Short Bowel Syndrome]." Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery, vol. 9, no. 5, 2006, pp. 441-4.
Wu GH, Chen J, Li H, et al. [Effects of glucagon-like peptide 2 on the adaptation of residual small bowel in a rat model of short bowel syndrome]. Zhonghua Wei Chang Wai Ke Za Zhi. 2006;9(5):441-4.
Wu, G. H., Chen, J., Li, H., & Wu, Z. H. (2006). [Effects of glucagon-like peptide 2 on the adaptation of residual small bowel in a rat model of short bowel syndrome]. Zhonghua Wei Chang Wai Ke Za Zhi = Chinese Journal of Gastrointestinal Surgery, 9(5), 441-4.
Wu GH, et al. [Effects of Glucagon-like Peptide 2 On the Adaptation of Residual Small Bowel in a Rat Model of Short Bowel Syndrome]. Zhonghua Wei Chang Wai Ke Za Zhi. 2006;9(5):441-4. PubMed PMID: 17043970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of glucagon-like peptide 2 on the adaptation of residual small bowel in a rat model of short bowel syndrome]. AU - Wu,Guo-Hao, AU - Chen,Ji, AU - Li,Hang, AU - Wu,Zhao-Han, PY - 2006/10/18/pubmed PY - 2009/11/10/medline PY - 2006/10/18/entrez SP - 441 EP - 4 JF - Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery JO - Zhonghua Wei Chang Wai Ke Za Zhi VL - 9 IS - 5 N2 - OBJECTIVE: To investigate the effects of glucagon-like peptide 2 (GLP-2) on the morphology and functional adaptation of the residual small bowel in rat model of short bowel syndrome. METHODS: Twenty rats with 75% of the midjejunoileum removed were randomly divided into two groups, and received intra-peritoneal injection of GLP-2(250 micro*gd*kg-1*d-1) or subcutaneous injection saline(0.5 ml, twice one day) after operation. On postoperative day 6, the morphological changes of the residual jejunum and ileum, the expression of proliferating cell nuclear antigen(PCNA), and the mRNA expressions of Na-D-glucose cotransporters (SGLT1) and peptide cotransporters (PEPT1) were determined. The intestinal glucose absorption data per unit length as well as per unit weight of ileum were measured by in vivo circulatory perfusion experiment. RESULTS: The morphological parameters of the residual gut such as the thickness of mucosa, height of villus, depth of crypt, and PCNA positive index were significantly higher, while the apoptosis rate per unit of mucosal square was significantly lower in GLP-2 treatment group than those in the control group. The expressions of mRNA SGTLl and PEPT1 in the residual ileum were significantly higher than those in the control group. There was no significant difference in glucose absorption rate per gram of mucosal wet weight between the two groups (P > 0.05). CONCLUSION: GLP-2 could improve morphological and functional adaptation of the residual small bowel by stimulating enterocyte proliferation and decreasing enterocyte apoptosis in short bowel syndrome. SN - 1671-0274 UR - https://www.unboundmedicine.com/medline/citation/17043970/[Effects_of_glucagon_like_peptide_2_on_the_adaptation_of_residual_small_bowel_in_a_rat_model_of_short_bowel_syndrome]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&issn=1671-0274&year=2006&vol=9&issue=5&fpage=441 DB - PRIME DP - Unbound Medicine ER -