Tags

Type your tag names separated by a space and hit enter

Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2.
Genes Chromosomes Cancer. 2007 Jan; 46(1):45-52.GC

Abstract

The distal part of 1p is frequently deleted in aggressive neuroblastoma, and the region is believed to harbor one or more tumor suppressor genes relevant to tumor development. To analyze differences among neuroblastoma tumors, an expression profile was established for the genes mapped within a previously described shortest region of overlap of deletions at 1p36.2. The gene expression levels were quantified by TaqMan real-time (RT)-PCR for 30 transcripts using 55 primary neuroblastoma tumors. Here we report on a significant decrease in gene expression of the genes RERE, PIK3CD, LZIC, PGD, and PEX14 and an increase of SLC2A5 when comparing tumors of favorable biology to Stage 4 neuroblastomas. When comparing 1p-deleted tumors of all stages to tumors with an intact 1p, a significant difference at gene-by-gene level in TNFRSF9, RERE, PIK3CD, CLSTN1, CTNNBIP1, and CASZ1 was detected. A complete loss of expression could not be seen for any single gene analyzed. Several of the genes with diminished expression in unfavorable or 1p-deleted tumors have functions that could contribute to tumor development. It is also possible that a combination of lowly expressed genes at 1p, rather than one single classical tumor suppressor gene, causes the unfavorable outcome associated with 1p-deletion in neuroblastoma.

Authors+Show Affiliations

Department of Clinical Genetics, University of Gothenburg, Sahlgrenska University Hospital-East, S-416 85 Gothenburg, Sweden. susanne.fransson@clingen.gu.seNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17044048

Citation

Fransson, Susanne, et al. "Neuroblastoma Tumors With Favorable and Unfavorable Outcomes: Significant Differences in mRNA Expression of Genes Mapped at 1p36.2." Genes, Chromosomes & Cancer, vol. 46, no. 1, 2007, pp. 45-52.
Fransson S, Martinsson T, Ejeskär K. Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2. Genes Chromosomes Cancer. 2007;46(1):45-52.
Fransson, S., Martinsson, T., & Ejeskär, K. (2007). Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2. Genes, Chromosomes & Cancer, 46(1), 45-52.
Fransson S, Martinsson T, Ejeskär K. Neuroblastoma Tumors With Favorable and Unfavorable Outcomes: Significant Differences in mRNA Expression of Genes Mapped at 1p36.2. Genes Chromosomes Cancer. 2007;46(1):45-52. PubMed PMID: 17044048.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroblastoma tumors with favorable and unfavorable outcomes: Significant differences in mRNA expression of genes mapped at 1p36.2. AU - Fransson,Susanne, AU - Martinsson,Tommy, AU - Ejeskär,Katarina, PY - 2006/10/18/pubmed PY - 2007/1/30/medline PY - 2006/10/18/entrez SP - 45 EP - 52 JF - Genes, chromosomes & cancer JO - Genes Chromosomes Cancer VL - 46 IS - 1 N2 - The distal part of 1p is frequently deleted in aggressive neuroblastoma, and the region is believed to harbor one or more tumor suppressor genes relevant to tumor development. To analyze differences among neuroblastoma tumors, an expression profile was established for the genes mapped within a previously described shortest region of overlap of deletions at 1p36.2. The gene expression levels were quantified by TaqMan real-time (RT)-PCR for 30 transcripts using 55 primary neuroblastoma tumors. Here we report on a significant decrease in gene expression of the genes RERE, PIK3CD, LZIC, PGD, and PEX14 and an increase of SLC2A5 when comparing tumors of favorable biology to Stage 4 neuroblastomas. When comparing 1p-deleted tumors of all stages to tumors with an intact 1p, a significant difference at gene-by-gene level in TNFRSF9, RERE, PIK3CD, CLSTN1, CTNNBIP1, and CASZ1 was detected. A complete loss of expression could not be seen for any single gene analyzed. Several of the genes with diminished expression in unfavorable or 1p-deleted tumors have functions that could contribute to tumor development. It is also possible that a combination of lowly expressed genes at 1p, rather than one single classical tumor suppressor gene, causes the unfavorable outcome associated with 1p-deletion in neuroblastoma. SN - 1045-2257 UR - https://www.unboundmedicine.com/medline/citation/17044048/Neuroblastoma_tumors_with_favorable_and_unfavorable_outcomes:_Significant_differences_in_mRNA_expression_of_genes_mapped_at_1p36_2_ L2 - https://doi.org/10.1002/gcc.20387 DB - PRIME DP - Unbound Medicine ER -