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Parkinson's disease in Africa: A systematic review of epidemiologic and genetic studies.
Mov Disord. 2006 Dec; 21(12):2150-6.MD

Abstract

Parkinson's disease (PD) occurs worldwide, but little is known about PD in Africa. We systematically reviewed publications on PD in Africa, with emphasis on epidemiologic and genetic studies. Articles published between 1944 and December 2004 were identified using several strategies. The studies emanated from 13 African countries (Kenya, Uganda, Tanzania, Ethiopia, Nigeria, Senegal, Ghana, Togo, Libya, Tunisia, Algeria, Zimbabwe, and South Africa). The publications fell into four categories: clinical series (n = 17), prevalence studies (n = 7), incidence studies (n = 1), and genetic studies (n = 3). The clinical series documented the occurrence of PD in Africa and described its clinical characteristics. The prevalence studies suggested some intracontinental geographic variation in PD prevalence. Overall, the prevalence figures and the incidence rates of PD in Africa appeared lower than those reported for European and North American populations. Few genetic studies of PD have been reported from Africa, and none in blacks. There are no case-control or cohort studies of PD reported from Africa. This review provides a summary of PD research in Africa over the past 60 years and highlights the information gaps and potential areas for future research.

Authors+Show Affiliations

Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review
Systematic Review

Language

eng

PubMed ID

17044056

Citation

Okubadejo, Njideka U., et al. "Parkinson's Disease in Africa: a Systematic Review of Epidemiologic and Genetic Studies." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 21, no. 12, 2006, pp. 2150-6.
Okubadejo NU, Bower JH, Rocca WA, et al. Parkinson's disease in Africa: A systematic review of epidemiologic and genetic studies. Mov Disord. 2006;21(12):2150-6.
Okubadejo, N. U., Bower, J. H., Rocca, W. A., & Maraganore, D. M. (2006). Parkinson's disease in Africa: A systematic review of epidemiologic and genetic studies. Movement Disorders : Official Journal of the Movement Disorder Society, 21(12), 2150-6.
Okubadejo NU, et al. Parkinson's Disease in Africa: a Systematic Review of Epidemiologic and Genetic Studies. Mov Disord. 2006;21(12):2150-6. PubMed PMID: 17044056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease in Africa: A systematic review of epidemiologic and genetic studies. AU - Okubadejo,Njideka U, AU - Bower,James H, AU - Rocca,Walter A, AU - Maraganore,Demetrius M, PY - 2006/10/18/pubmed PY - 2007/2/21/medline PY - 2006/10/18/entrez SP - 2150 EP - 6 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 21 IS - 12 N2 - Parkinson's disease (PD) occurs worldwide, but little is known about PD in Africa. We systematically reviewed publications on PD in Africa, with emphasis on epidemiologic and genetic studies. Articles published between 1944 and December 2004 were identified using several strategies. The studies emanated from 13 African countries (Kenya, Uganda, Tanzania, Ethiopia, Nigeria, Senegal, Ghana, Togo, Libya, Tunisia, Algeria, Zimbabwe, and South Africa). The publications fell into four categories: clinical series (n = 17), prevalence studies (n = 7), incidence studies (n = 1), and genetic studies (n = 3). The clinical series documented the occurrence of PD in Africa and described its clinical characteristics. The prevalence studies suggested some intracontinental geographic variation in PD prevalence. Overall, the prevalence figures and the incidence rates of PD in Africa appeared lower than those reported for European and North American populations. Few genetic studies of PD have been reported from Africa, and none in blacks. There are no case-control or cohort studies of PD reported from Africa. This review provides a summary of PD research in Africa over the past 60 years and highlights the information gaps and potential areas for future research. SN - 0885-3185 UR - https://www.unboundmedicine.com/medline/citation/17044056/Parkinson's_disease_in_Africa:_A_systematic_review_of_epidemiologic_and_genetic_studies_ L2 - https://doi.org/10.1002/mds.21153 DB - PRIME DP - Unbound Medicine ER -