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Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometry.
Rapid Commun Mass Spectrom. 2006; 20(22):3275-88.RC

Abstract

Cortex Moutan is a well-known traditional Chinese medicine derived from Paeonia suffruticosa ANDREWS. However, root cortices of P. delavayi and P. decomposita also are used under the name of this drug in some regions such as Yunnan and Sichuan Provinces, respectively. In order to make a comparison of their chemical constituents, the compounds of the three Paeonia species were analyzed by high-performance liquid chromatography-diode array detection/electrospray ionization and quadrupole-time-of-flight tandem mass spectrometry (HPLC-DAD/ESI-MS2). A total of 50 compounds were observed in the 50% (v/v) methanolic extracts, including 17 monoterpenes, 14 galloyl glucoses, 10 acetophenones, 5 phenolic acids, 3 flavonoids and 1 triterpene. These chemical constituents were separated on a C18 column and identified or tentatively characterized based on UV spectra and MS fragmentation behavior. The chemical compositions of the three Paeonia species were found to have many differences. Paeonol was the predominant constituent of P. suffruticosa and P. decomposita, while P. delavayi contained albiflorin and more galloyl glucoses than the other two Paeonia species. Most of these identified compounds have been reported from P. delavayi and P. decomposita for the first time. The ESI-MS fragmentation behavior of monoterpene glycosides, acetophenones and galloyl glucoses was also investigated successively, and appropriate characteristic pathways were proposed. The large differences in chemical compounds among the three Paeonia species strongly encouraged further comparison of the bioactivities of these three species.

Authors+Show Affiliations

Department of Pharmacognosy, China Pharmaceutical University, Nanjing 210038, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17044128

Citation

Xu, Shun-jun, et al. "Characterization of Compounds in the Chinese Herbal Drug Mu-Dan-Pi By Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry." Rapid Communications in Mass Spectrometry : RCM, vol. 20, no. 22, 2006, pp. 3275-88.
Xu SJ, Yang L, Zeng X, et al. Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Commun Mass Spectrom. 2006;20(22):3275-88.
Xu, S. J., Yang, L., Zeng, X., Zhang, M., & Wang, Z. T. (2006). Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometry. Rapid Communications in Mass Spectrometry : RCM, 20(22), 3275-88.
Xu SJ, et al. Characterization of Compounds in the Chinese Herbal Drug Mu-Dan-Pi By Liquid Chromatography Coupled to Electrospray Ionization Mass Spectrometry. Rapid Commun Mass Spectrom. 2006;20(22):3275-88. PubMed PMID: 17044128.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of compounds in the Chinese herbal drug Mu-Dan-Pi by liquid chromatography coupled to electrospray ionization mass spectrometry. AU - Xu,Shun-jun, AU - Yang,Liu, AU - Zeng,Xing, AU - Zhang,Mian, AU - Wang,Zheng-tao, PY - 2006/10/18/pubmed PY - 2007/1/20/medline PY - 2006/10/18/entrez SP - 3275 EP - 88 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 20 IS - 22 N2 - Cortex Moutan is a well-known traditional Chinese medicine derived from Paeonia suffruticosa ANDREWS. However, root cortices of P. delavayi and P. decomposita also are used under the name of this drug in some regions such as Yunnan and Sichuan Provinces, respectively. In order to make a comparison of their chemical constituents, the compounds of the three Paeonia species were analyzed by high-performance liquid chromatography-diode array detection/electrospray ionization and quadrupole-time-of-flight tandem mass spectrometry (HPLC-DAD/ESI-MS2). A total of 50 compounds were observed in the 50% (v/v) methanolic extracts, including 17 monoterpenes, 14 galloyl glucoses, 10 acetophenones, 5 phenolic acids, 3 flavonoids and 1 triterpene. These chemical constituents were separated on a C18 column and identified or tentatively characterized based on UV spectra and MS fragmentation behavior. The chemical compositions of the three Paeonia species were found to have many differences. Paeonol was the predominant constituent of P. suffruticosa and P. decomposita, while P. delavayi contained albiflorin and more galloyl glucoses than the other two Paeonia species. Most of these identified compounds have been reported from P. delavayi and P. decomposita for the first time. The ESI-MS fragmentation behavior of monoterpene glycosides, acetophenones and galloyl glucoses was also investigated successively, and appropriate characteristic pathways were proposed. The large differences in chemical compounds among the three Paeonia species strongly encouraged further comparison of the bioactivities of these three species. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/17044128/Characterization_of_compounds_in_the_Chinese_herbal_drug_Mu_Dan_Pi_by_liquid_chromatography_coupled_to_electrospray_ionization_mass_spectrometry_ L2 - https://doi.org/10.1002/rcm.2717 DB - PRIME DP - Unbound Medicine ER -