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The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns.
Ann Hum Genet. 2006 Nov; 70(Pt 6):951-7.AH

Abstract

Factor VII (FVII) is an independent risk factor for coronary artery disease. Three polymorphisms of the factor VII gene (F7) were studied in a group of healthy newborns comprising 561 Chinese, 398 Malays and 226 Asian Indians from Singapore. The allele frequencies of 3 polymorphisms (R353Q, Promoter 0/10bp Del/Ins and Intron 7) in the FVII gene were ascertained through genotyping by polymerase chain reaction and restriction digestion of amplified fragments. In Chinese the minor allele frequencies are Q: 0.04, Ins: 0.03, R7: 0.44; Malays, Q: 0.06, Ins: 0.10, R7: 0.41; and Indians, Q: 0.25, Ins: 0.23, R7: 0.43. Strong linkage disequilibrium (Delta > 0.7) is observed between the 0/10 bp and the R353Q sites in all ethnic groups. We conclude that: (i) the prevalence of the minor Q and Ins alleles of the R353Q and 0/10 bp polymorphisms are significantly higher in the Indian newborns than the Chinese and Malays; (ii) the Q allele is significantly associated (p = 0.01) with a lower plasma FVII coagulant level in the Indian and Malay neonates; and this polymorphism explains up to 3.8% of the variance in FVII coagulant levels; (iii) there is no significant difference in allele frequencies of the three polymorphisms between neonates with and without family histories of CAD.

Authors+Show Affiliations

Department of Paediatrics, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17044869

Citation

Quek, S C., et al. "The Effects of Three Factor VII Polymorphisms On Factor VII Coagulant Levels in Healthy Singaporean Chinese, Malay and Indian Newborns." Annals of Human Genetics, vol. 70, no. Pt 6, 2006, pp. 951-7.
Quek SC, Low PS, Saha N, et al. The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns. Ann Hum Genet. 2006;70(Pt 6):951-7.
Quek, S. C., Low, P. S., Saha, N., & Heng, C. K. (2006). The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns. Annals of Human Genetics, 70(Pt 6), 951-7.
Quek SC, et al. The Effects of Three Factor VII Polymorphisms On Factor VII Coagulant Levels in Healthy Singaporean Chinese, Malay and Indian Newborns. Ann Hum Genet. 2006;70(Pt 6):951-7. PubMed PMID: 17044869.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of three factor VII polymorphisms on factor VII coagulant levels in healthy Singaporean Chinese, Malay and Indian newborns. AU - Quek,S C, AU - Low,P S, AU - Saha,N, AU - Heng,C K, PY - 2006/10/19/pubmed PY - 2006/12/12/medline PY - 2006/10/19/entrez SP - 951 EP - 7 JF - Annals of human genetics JO - Ann Hum Genet VL - 70 IS - Pt 6 N2 - Factor VII (FVII) is an independent risk factor for coronary artery disease. Three polymorphisms of the factor VII gene (F7) were studied in a group of healthy newborns comprising 561 Chinese, 398 Malays and 226 Asian Indians from Singapore. The allele frequencies of 3 polymorphisms (R353Q, Promoter 0/10bp Del/Ins and Intron 7) in the FVII gene were ascertained through genotyping by polymerase chain reaction and restriction digestion of amplified fragments. In Chinese the minor allele frequencies are Q: 0.04, Ins: 0.03, R7: 0.44; Malays, Q: 0.06, Ins: 0.10, R7: 0.41; and Indians, Q: 0.25, Ins: 0.23, R7: 0.43. Strong linkage disequilibrium (Delta > 0.7) is observed between the 0/10 bp and the R353Q sites in all ethnic groups. We conclude that: (i) the prevalence of the minor Q and Ins alleles of the R353Q and 0/10 bp polymorphisms are significantly higher in the Indian newborns than the Chinese and Malays; (ii) the Q allele is significantly associated (p = 0.01) with a lower plasma FVII coagulant level in the Indian and Malay neonates; and this polymorphism explains up to 3.8% of the variance in FVII coagulant levels; (iii) there is no significant difference in allele frequencies of the three polymorphisms between neonates with and without family histories of CAD. SN - 0003-4800 UR - https://www.unboundmedicine.com/medline/citation/17044869/The_effects_of_three_factor_VII_polymorphisms_on_factor_VII_coagulant_levels_in_healthy_Singaporean_Chinese_Malay_and_Indian_newborns_ L2 - https://doi.org/10.1111/j.1469-1809.2006.00282.x DB - PRIME DP - Unbound Medicine ER -