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[The role of urotensin II in airway remodeling of asthma].
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jun; 29(6):381-4.ZJ

Abstract

OBJECTIVE

To observe the change of urotensin II (U-II) expression in airways of rat asthmatic models, and of patients with asthma, and therefore to investigate the role of U-II in the pathogenesis of asthma and airway remodeling.

METHODS

Twenty Wistar rats were divided into a control group (10 rats) and an asthmatic group (10 rats). The animal model of asthma was established by ovalbumin intraperitoneal injection and aerosolization. The internal perimeter of bronchi (Pi), bronchial wall area (WA) and the area of bronchial smooth muscle (WAm) were measured by a computerized image analyzer, and the WA/Pi and WAm/Pi were calculated to express airway remodeling. Autopsy lung tissues from 5 patients with asthma and 5 normal human controls died of car accident were collected, stained with hematoxylin and eosin stain, and the streptavidin peroxidase method. The expression level of U-II and the percentage of positive U-II cell in the airways of rats and patients with asthma were measured.

RESULTS

Rats exposed to ovalbumin developed asthma and airway remodeling: the WA/Pi and WAm/Pi [(24.1 +/- 2.4) microm(2)/microm, (5.3 +/- 1.9) microm(2)/microm] were increased, as compared with the normal group [(16.5 +/- 1.7) microm(2)/microm, (3.8 +/- 1.2) microm(2)/microm], the difference being significant (t = 3.892, 3.785, all P < 0.01). The expression level of U-II in asthmatic rats was 2.46 +/- 0.15, while in the control group was 1.26 +/- 0.11, the difference being significant (t = 6.236, P < 0.01). There was a positive correlation between the level of U-II and WAm/Pi (r = 0.712, P < 0.01). The percentage of positive U-II cells in the asthmatic rats was (82 +/- 8)%, while in the control rats was (22 +/- 8)%, the difference being significant (t = 19.102, P < 0.01). The expression level of U-II in patients with asthma was 2.61 +/- 0.19, while in the control group was 1.36 +/- 0.12, the difference being significant (t = 7.374, P < 0.01). The percentage of positive U-II cells in patients with asthma was (75 +/- 9)%, while in the controls was (27 +/- 7)%, the difference being significant (t = 16.236, P < 0.01).

CONCLUSION

The expression of U-II is increased in airways of rat asthmatic models and of patients with asthma. It may play an important role in the pathogenesis of asthma and airway remodeling.

Authors+Show Affiliations

Department of Respiratory Medicine, West China Hospital of Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17045018

Citation

Cheng, De-yun, et al. "[The Role of Urotensin II in Airway Remodeling of Asthma]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 29, no. 6, 2006, pp. 381-4.
Cheng DY, Fan LL, Yi XF. [The role of urotensin II in airway remodeling of asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(6):381-4.
Cheng, D. Y., Fan, L. L., & Yi, X. F. (2006). [The role of urotensin II in airway remodeling of asthma]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 29(6), 381-4.
Cheng DY, Fan LL, Yi XF. [The Role of Urotensin II in Airway Remodeling of Asthma]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(6):381-4. PubMed PMID: 17045018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The role of urotensin II in airway remodeling of asthma]. AU - Cheng,De-yun, AU - Fan,Li-li, AU - Yi,Xu-fu, PY - 2006/10/19/pubmed PY - 2010/9/8/medline PY - 2006/10/19/entrez SP - 381 EP - 4 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 29 IS - 6 N2 - OBJECTIVE: To observe the change of urotensin II (U-II) expression in airways of rat asthmatic models, and of patients with asthma, and therefore to investigate the role of U-II in the pathogenesis of asthma and airway remodeling. METHODS: Twenty Wistar rats were divided into a control group (10 rats) and an asthmatic group (10 rats). The animal model of asthma was established by ovalbumin intraperitoneal injection and aerosolization. The internal perimeter of bronchi (Pi), bronchial wall area (WA) and the area of bronchial smooth muscle (WAm) were measured by a computerized image analyzer, and the WA/Pi and WAm/Pi were calculated to express airway remodeling. Autopsy lung tissues from 5 patients with asthma and 5 normal human controls died of car accident were collected, stained with hematoxylin and eosin stain, and the streptavidin peroxidase method. The expression level of U-II and the percentage of positive U-II cell in the airways of rats and patients with asthma were measured. RESULTS: Rats exposed to ovalbumin developed asthma and airway remodeling: the WA/Pi and WAm/Pi [(24.1 +/- 2.4) microm(2)/microm, (5.3 +/- 1.9) microm(2)/microm] were increased, as compared with the normal group [(16.5 +/- 1.7) microm(2)/microm, (3.8 +/- 1.2) microm(2)/microm], the difference being significant (t = 3.892, 3.785, all P < 0.01). The expression level of U-II in asthmatic rats was 2.46 +/- 0.15, while in the control group was 1.26 +/- 0.11, the difference being significant (t = 6.236, P < 0.01). There was a positive correlation between the level of U-II and WAm/Pi (r = 0.712, P < 0.01). The percentage of positive U-II cells in the asthmatic rats was (82 +/- 8)%, while in the control rats was (22 +/- 8)%, the difference being significant (t = 19.102, P < 0.01). The expression level of U-II in patients with asthma was 2.61 +/- 0.19, while in the control group was 1.36 +/- 0.12, the difference being significant (t = 7.374, P < 0.01). The percentage of positive U-II cells in patients with asthma was (75 +/- 9)%, while in the controls was (27 +/- 7)%, the difference being significant (t = 16.236, P < 0.01). CONCLUSION: The expression of U-II is increased in airways of rat asthmatic models and of patients with asthma. It may play an important role in the pathogenesis of asthma and airway remodeling. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/17045018/[The_role_of_urotensin_II_in_airway_remodeling_of_asthma]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2006&amp;vol=29&amp;issue=6&amp;fpage=381 DB - PRIME DP - Unbound Medicine ER -
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