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[Changes of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the bronchoalveolar lavage fluid and the serum of patients with idiopathic pulmonary fibrosis].
Zhonghua Jie He He Hu Xi Za Zhi. 2006 Jun; 29(6):399-402.ZJ

Abstract

OBJECTIVE

To detect the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the bronchoalveolar lavage fluid (BALF) and the serum of patients with idiopathic pulmonary fibrosis (IPF), and to evaluate the significance of the changes in the pathogenesis of IPF.

METHODS

Enzyme-linked immunoadsorbent assay (ELISA) was used to detect MMP-9 and TIMP-1 in the BALF and serum of 30 patients with IPF.

RESULTS

The levels of MMP-9 in the BALF and serum of the patients showed no significant difference as compared with those of the control group. The levels of TIMP-1 in the BALF [(522 +/- 81) ng/L] and serum [(166 +/- 29) ng/L] of the patients were higher than those [(201 +/- 31), (87 +/- 16) ng/L] of the control group (P < 0.01). The ratios of MMP-9/TIMP-1 in the BALF (0.53 +/- 0.18) and serum (1.5 +/- 0.3) of patients with IPF were lower than those (1.06 +/- 0.38, 2.6 +/- 0.5) of the control group (P < 0.01, < 0.05). TIMP-1 in the BALF of the patients showed a strong positive correlation with chest CT fibrosis and pulmonary function test scores (P < 0.01), while MMP-9/TIMP-1 in the BALF had negative correlation with them (P < 0.01).

CONCLUSION

Pulmonary fibrosis may be associated with increased TIMP-1 and decreased MMP-9/TIMP-1, which is able to inhibit the degradation of extracellular matrix.

Authors+Show Affiliations

Institute of Respiratory Disease, First Affiliated Hospital, China Medical University, Shenyang 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17045024

Citation

Wei, Lu-qing, et al. "[Changes of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in the Bronchoalveolar Lavage Fluid and the Serum of Patients With Idiopathic Pulmonary Fibrosis]." Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, vol. 29, no. 6, 2006, pp. 399-402.
Wei LQ, Li ZH, Kang J, et al. [Changes of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the bronchoalveolar lavage fluid and the serum of patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(6):399-402.
Wei, L. Q., Li, Z. H., Kang, J., Hou, X. M., & Yu, R. J. (2006). [Changes of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the bronchoalveolar lavage fluid and the serum of patients with idiopathic pulmonary fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi = Zhonghua Jiehe He Huxi Zazhi = Chinese Journal of Tuberculosis and Respiratory Diseases, 29(6), 399-402.
Wei LQ, et al. [Changes of Matrix Metalloproteinase-9 and Tissue Inhibitor of Metalloproteinase-1 in the Bronchoalveolar Lavage Fluid and the Serum of Patients With Idiopathic Pulmonary Fibrosis]. Zhonghua Jie He He Hu Xi Za Zhi. 2006;29(6):399-402. PubMed PMID: 17045024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Changes of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in the bronchoalveolar lavage fluid and the serum of patients with idiopathic pulmonary fibrosis]. AU - Wei,Lu-qing, AU - Li,Zhen-hua, AU - Kang,Jian, AU - Hou,Xian-ming, AU - Yu,Run-jiang, PY - 2006/10/19/pubmed PY - 2010/9/8/medline PY - 2006/10/19/entrez SP - 399 EP - 402 JF - Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases JO - Zhonghua Jie He He Hu Xi Za Zhi VL - 29 IS - 6 N2 - OBJECTIVE: To detect the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in the bronchoalveolar lavage fluid (BALF) and the serum of patients with idiopathic pulmonary fibrosis (IPF), and to evaluate the significance of the changes in the pathogenesis of IPF. METHODS: Enzyme-linked immunoadsorbent assay (ELISA) was used to detect MMP-9 and TIMP-1 in the BALF and serum of 30 patients with IPF. RESULTS: The levels of MMP-9 in the BALF and serum of the patients showed no significant difference as compared with those of the control group. The levels of TIMP-1 in the BALF [(522 +/- 81) ng/L] and serum [(166 +/- 29) ng/L] of the patients were higher than those [(201 +/- 31), (87 +/- 16) ng/L] of the control group (P < 0.01). The ratios of MMP-9/TIMP-1 in the BALF (0.53 +/- 0.18) and serum (1.5 +/- 0.3) of patients with IPF were lower than those (1.06 +/- 0.38, 2.6 +/- 0.5) of the control group (P < 0.01, < 0.05). TIMP-1 in the BALF of the patients showed a strong positive correlation with chest CT fibrosis and pulmonary function test scores (P < 0.01), while MMP-9/TIMP-1 in the BALF had negative correlation with them (P < 0.01). CONCLUSION: Pulmonary fibrosis may be associated with increased TIMP-1 and decreased MMP-9/TIMP-1, which is able to inhibit the degradation of extracellular matrix. SN - 1001-0939 UR - https://www.unboundmedicine.com/medline/citation/17045024/[Changes_of_matrix_metalloproteinase_9_and_tissue_inhibitor_of_metalloproteinase_1_in_the_bronchoalveolar_lavage_fluid_and_the_serum_of_patients_with_idiopathic_pulmonary_fibrosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=1001-0939&amp;year=2006&amp;vol=29&amp;issue=6&amp;fpage=399 DB - PRIME DP - Unbound Medicine ER -