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Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma.
Exp Neurol. 2007 Jan; 203(1):269-73.EN

Abstract

Glaucoma is one of the major neurological disorders in eye leading to irreversible blindness in elderly. Increase in intraocular pressure (IOP) has been considered to be the major risk factor for the progressive loss of retinal ganglion cells (RGCs) in retina. While attenuation of IOP has been a major pharmaceutical target, reduction of IOP cannot prevent progressive loss of RGCs. In this regard, urgent need for alternative treatment has to be investigated. Anti-aging medicinal herb Lycium barbarum L. has been used for centuries in Eastern World to protect the eyes and maintain good health. Using an ocular hypertension (OH) model in rat by laser photocoagulation of episcleral and limbal veins, we attempted to investigate whether L. barbarum can promote RGCs survival against elevated IOP. Oral administration of L. barbarum in Sprague-Dawley rats (250-280 g) significantly reduced the loss of RGCs, although elevated IOP was not significantly altered. Rats fed with the 1 mg/kg extract could nearly totally escape from pressure-induced loss of RGCs. In conclusion, this is the first in vivo report showing the therapeutic function of L. barbarum against neurodegeneration in the retina of rat OH model. The results demonstrate that this extract may be a potential candidate for the development of neuroprotective drug against the loss of RGCs in glaucoma.

Authors+Show Affiliations

Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17045262

Citation

Chan, Hiu-Chi, et al. "Neuroprotective Effects of Lycium Barbarum Lynn On Protecting Retinal Ganglion Cells in an Ocular Hypertension Model of Glaucoma." Experimental Neurology, vol. 203, no. 1, 2007, pp. 269-73.
Chan HC, Chang RC, Koon-Ching Ip A, et al. Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Exp Neurol. 2007;203(1):269-73.
Chan, H. C., Chang, R. C., Koon-Ching Ip, A., Chiu, K., Yuen, W. H., Zee, S. Y., & So, K. F. (2007). Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. Experimental Neurology, 203(1), 269-73.
Chan HC, et al. Neuroprotective Effects of Lycium Barbarum Lynn On Protecting Retinal Ganglion Cells in an Ocular Hypertension Model of Glaucoma. Exp Neurol. 2007;203(1):269-73. PubMed PMID: 17045262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of Lycium barbarum Lynn on protecting retinal ganglion cells in an ocular hypertension model of glaucoma. AU - Chan,Hiu-Chi, AU - Chang,Raymond Chuen-Chung, AU - Koon-Ching Ip,Angel, AU - Chiu,Kin, AU - Yuen,Wai-Hung, AU - Zee,Sze-Yong, AU - So,Kwok-Fai, Y1 - 2006/10/11/ PY - 2006/03/07/received PY - 2006/05/08/revised PY - 2006/05/23/accepted PY - 2006/10/19/pubmed PY - 2007/2/24/medline PY - 2006/10/19/entrez SP - 269 EP - 73 JF - Experimental neurology JO - Exp Neurol VL - 203 IS - 1 N2 - Glaucoma is one of the major neurological disorders in eye leading to irreversible blindness in elderly. Increase in intraocular pressure (IOP) has been considered to be the major risk factor for the progressive loss of retinal ganglion cells (RGCs) in retina. While attenuation of IOP has been a major pharmaceutical target, reduction of IOP cannot prevent progressive loss of RGCs. In this regard, urgent need for alternative treatment has to be investigated. Anti-aging medicinal herb Lycium barbarum L. has been used for centuries in Eastern World to protect the eyes and maintain good health. Using an ocular hypertension (OH) model in rat by laser photocoagulation of episcleral and limbal veins, we attempted to investigate whether L. barbarum can promote RGCs survival against elevated IOP. Oral administration of L. barbarum in Sprague-Dawley rats (250-280 g) significantly reduced the loss of RGCs, although elevated IOP was not significantly altered. Rats fed with the 1 mg/kg extract could nearly totally escape from pressure-induced loss of RGCs. In conclusion, this is the first in vivo report showing the therapeutic function of L. barbarum against neurodegeneration in the retina of rat OH model. The results demonstrate that this extract may be a potential candidate for the development of neuroprotective drug against the loss of RGCs in glaucoma. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/17045262/Neuroprotective_effects_of_Lycium_barbarum_Lynn_on_protecting_retinal_ganglion_cells_in_an_ocular_hypertension_model_of_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(06)00360-8 DB - PRIME DP - Unbound Medicine ER -