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Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury.
Exp Neurol 2007; 204(1):454-7EN

Abstract

Spinal cord injury (SCI) pain exhibits many symptoms associated with peripheral neuropathic pain, including increased tactile hypersensitivity. One novel approach to ameliorate SCI pain is the use of cannabinoid (CB) ligands. The current study evaluated the efficacy of the nonselective CB receptor agonist WIN 55,212-2 on tactile hypersensitivity in rats following a brief compression to the thoracic spinal cord. The withdrawal thresholds of the hind paws following SCI were significantly decreased, indicating tactile hypersensitivity. Systemic injection of WIN 55,212-2 increased withdrawal thresholds in a dose-dependent manner. Pretreatment with the CB(1) receptor subtype-selective antagonist AM 251 completely abolished the antinociceptive effect of WIN 55,212-2 whereas pretreatment with the CB(2) receptor subtype-selective antagonist AM 630 did not alter the antinociceptive effect of WIN 55,212-2. These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain.

Authors+Show Affiliations

University of Miami Miller School of Medicine, The Miami Project to Cure Paralysis, 1095 NW 14th Terrace (R-48), Miami, FL 33136, USA. ahama@med.miami.eduNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17045264

Citation

Hama, Aldric, and Jacqueline Sagen. "Antinociceptive Effect of Cannabinoid Agonist WIN 55,212-2 in Rats With a Spinal Cord Injury." Experimental Neurology, vol. 204, no. 1, 2007, pp. 454-7.
Hama A, Sagen J. Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury. Exp Neurol. 2007;204(1):454-7.
Hama, A., & Sagen, J. (2007). Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury. Experimental Neurology, 204(1), pp. 454-7.
Hama A, Sagen J. Antinociceptive Effect of Cannabinoid Agonist WIN 55,212-2 in Rats With a Spinal Cord Injury. Exp Neurol. 2007;204(1):454-7. PubMed PMID: 17045264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antinociceptive effect of cannabinoid agonist WIN 55,212-2 in rats with a spinal cord injury. AU - Hama,Aldric, AU - Sagen,Jacqueline, Y1 - 2006/10/11/ PY - 2006/07/10/received PY - 2006/08/28/revised PY - 2006/09/09/accepted PY - 2006/10/19/pubmed PY - 2007/5/11/medline PY - 2006/10/19/entrez SP - 454 EP - 7 JF - Experimental neurology JO - Exp. Neurol. VL - 204 IS - 1 N2 - Spinal cord injury (SCI) pain exhibits many symptoms associated with peripheral neuropathic pain, including increased tactile hypersensitivity. One novel approach to ameliorate SCI pain is the use of cannabinoid (CB) ligands. The current study evaluated the efficacy of the nonselective CB receptor agonist WIN 55,212-2 on tactile hypersensitivity in rats following a brief compression to the thoracic spinal cord. The withdrawal thresholds of the hind paws following SCI were significantly decreased, indicating tactile hypersensitivity. Systemic injection of WIN 55,212-2 increased withdrawal thresholds in a dose-dependent manner. Pretreatment with the CB(1) receptor subtype-selective antagonist AM 251 completely abolished the antinociceptive effect of WIN 55,212-2 whereas pretreatment with the CB(2) receptor subtype-selective antagonist AM 630 did not alter the antinociceptive effect of WIN 55,212-2. These data indicate that a CB(1)-selective agonist may be novel therapeutic treatment for clinical SCI pain. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/17045264/Antinociceptive_effect_of_cannabinoid_agonist_WIN_55212_2_in_rats_with_a_spinal_cord_injury_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4886(06)00538-3 DB - PRIME DP - Unbound Medicine ER -