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Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease.
Nutrition 2006 Nov-Dec; 22(11-12):1146-51N

Abstract

OBJECTIVE

The purpose of this study was to investigate the association between plasma pyridoxal 5'-phosphate (PLP) status and lipid profiles and to estimate the relation to the risk of coronary artery disease (CAD).

METHODS

Patients who were identified by cardiac catheterization as having > or =70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. Plasma PLP, homocysteine, high-sensitivity C-reactive protein, lipid profiles (total cholesterol, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, and triacylglycerol) were determined.

RESULTS

Subjects with a plasma PLP level <30 nmol/L exhibited a significantly increased risk of CAD compared with subjects with a plasma PLP level > or =30 nmol/L (odds ratio, 1.85; 95% confidence interval, 1.16-2.95) after adjusting for homocysteine and high-sensitivity C-reactive protein. The association between PLP and the risk of CAD remained significant after each lipid profile was additionally adjusted. In addition, the combined presence of low PLP level and an abnormal lipid level increased the risk of CAD to an even greater degree.

CONCLUSIONS

A borderline vitamin B6 deficiency (plasma PLP concentration <30 nmol/L) is strongly associated with the risk of CAD. The combined presence of low PLP and abnormal lipid levels increased the risk of CAD even further.

Authors+Show Affiliations

School of Nutrition, Chung Shan Medical University, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17045461

Citation

Lin, Ping-Ting, et al. "Low Pyridoxal 5'-phosphate Is Associated With Increased Risk of Coronary Artery Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 22, no. 11-12, 2006, pp. 1146-51.
Lin PT, Cheng CH, Liaw YP, et al. Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. Nutrition. 2006;22(11-12):1146-51.
Lin, P. T., Cheng, C. H., Liaw, Y. P., Lee, B. J., Lee, T. W., & Huang, Y. C. (2006). Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. Nutrition (Burbank, Los Angeles County, Calif.), 22(11-12), pp. 1146-51.
Lin PT, et al. Low Pyridoxal 5'-phosphate Is Associated With Increased Risk of Coronary Artery Disease. Nutrition. 2006;22(11-12):1146-51. PubMed PMID: 17045461.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low pyridoxal 5'-phosphate is associated with increased risk of coronary artery disease. AU - Lin,Ping-Ting, AU - Cheng,Chien-Hsiang, AU - Liaw,Yung-Po, AU - Lee,Bor-Jen, AU - Lee,Tsung-Wen, AU - Huang,Yi-Chia, Y1 - 2006/10/10/ PY - 2006/03/03/received PY - 2006/08/01/revised PY - 2006/08/24/accepted PY - 2006/10/19/pubmed PY - 2007/2/9/medline PY - 2006/10/19/entrez SP - 1146 EP - 51 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 22 IS - 11-12 N2 - OBJECTIVE: The purpose of this study was to investigate the association between plasma pyridoxal 5'-phosphate (PLP) status and lipid profiles and to estimate the relation to the risk of coronary artery disease (CAD). METHODS: Patients who were identified by cardiac catheterization as having > or =70% stenosis of one major coronary artery were assigned to the case group (n = 184). The control group (n = 516) was comprised of healthy individuals with normal blood biochemical values. Plasma PLP, homocysteine, high-sensitivity C-reactive protein, lipid profiles (total cholesterol, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein, and triacylglycerol) were determined. RESULTS: Subjects with a plasma PLP level <30 nmol/L exhibited a significantly increased risk of CAD compared with subjects with a plasma PLP level > or =30 nmol/L (odds ratio, 1.85; 95% confidence interval, 1.16-2.95) after adjusting for homocysteine and high-sensitivity C-reactive protein. The association between PLP and the risk of CAD remained significant after each lipid profile was additionally adjusted. In addition, the combined presence of low PLP level and an abnormal lipid level increased the risk of CAD to an even greater degree. CONCLUSIONS: A borderline vitamin B6 deficiency (plasma PLP concentration <30 nmol/L) is strongly associated with the risk of CAD. The combined presence of low PLP and abnormal lipid levels increased the risk of CAD even further. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/17045461/Low_pyridoxal_5'_phosphate_is_associated_with_increased_risk_of_coronary_artery_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(06)00322-4 DB - PRIME DP - Unbound Medicine ER -