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Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function.
J Am Coll Cardiol. 2006 Oct 17; 48(8):1666-71.JACC

Abstract

OBJECTIVES

We sought to investigate whether the addition of walnuts or olive oil to a fatty meal have differential effects on postprandial vasoactivity, lipoproteins, markers of oxidation and endothelial activation, and plasma asymmetric dimethylarginine (ADMA).

BACKGROUND

Compared with a Mediterranean diet, a walnut diet has been shown to improve endothelial function in hypercholesterolemic patients. We hypothesized that walnuts would reverse postprandial endothelial dysfunction associated with consumption of a fatty meal.

METHODS

We randomized in a crossover design 12 healthy subjects and 12 patients with hypercholesterolemia to 2 high-fat meal sequences to which 25 g olive oil or 40 g walnuts had been added. Both test meals contained 80 g fat and 35% saturated fatty acids, and consumption of each meal was separated by 1 week. Venipunctures and ultrasound measurements of brachial artery endothelial function were performed after fasting and 4 h after test meals.

RESULTS

In both study groups, flow-mediated dilation (FMD) was worse after the olive oil meal than after the walnut meal (p = 0.006, time-period interaction). Fasting, but not postprandial, triglyceride concentrations correlated inversely with FMD (r = -0.324; p = 0.024). Flow-independent dilation and plasma ADMA concentrations were unchanged, and the concentration of oxidized low-density lipoproteins decreased (p = 0.051) after either meal. The plasma concentrations of soluble inflammatory cytokines and adhesion molecules decreased (p < 0.01) independently of meal type, except for E-selectin, which decreased more (p = 0.033) after the walnut meal.

CONCLUSIONS

Adding walnuts to a high-fat meal acutely improves FMD independently of changes in oxidation, inflammation, or ADMA. Both walnuts and olive oil preserve the protective phenotype of endothelial cells.

Authors+Show Affiliations

Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17045905

Citation

Cortés, Berenice, et al. "Acute Effects of High-fat Meals Enriched With Walnuts or Olive Oil On Postprandial Endothelial Function." Journal of the American College of Cardiology, vol. 48, no. 8, 2006, pp. 1666-71.
Cortés B, Núñez I, Cofán M, et al. Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. J Am Coll Cardiol. 2006;48(8):1666-71.
Cortés, B., Núñez, I., Cofán, M., Gilabert, R., Pérez-Heras, A., Casals, E., Deulofeu, R., & Ros, E. (2006). Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. Journal of the American College of Cardiology, 48(8), 1666-71.
Cortés B, et al. Acute Effects of High-fat Meals Enriched With Walnuts or Olive Oil On Postprandial Endothelial Function. J Am Coll Cardiol. 2006 Oct 17;48(8):1666-71. PubMed PMID: 17045905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute effects of high-fat meals enriched with walnuts or olive oil on postprandial endothelial function. AU - Cortés,Berenice, AU - Núñez,Isabel, AU - Cofán,Montserrat, AU - Gilabert,Rosa, AU - Pérez-Heras,Ana, AU - Casals,Elena, AU - Deulofeu,Ramón, AU - Ros,Emilio, Y1 - 2006/09/26/ PY - 2006/03/22/received PY - 2006/05/31/revised PY - 2006/06/06/accepted PY - 2006/10/19/pubmed PY - 2006/12/9/medline PY - 2006/10/19/entrez SP - 1666 EP - 71 JF - Journal of the American College of Cardiology JO - J. Am. Coll. Cardiol. VL - 48 IS - 8 N2 - OBJECTIVES: We sought to investigate whether the addition of walnuts or olive oil to a fatty meal have differential effects on postprandial vasoactivity, lipoproteins, markers of oxidation and endothelial activation, and plasma asymmetric dimethylarginine (ADMA). BACKGROUND: Compared with a Mediterranean diet, a walnut diet has been shown to improve endothelial function in hypercholesterolemic patients. We hypothesized that walnuts would reverse postprandial endothelial dysfunction associated with consumption of a fatty meal. METHODS: We randomized in a crossover design 12 healthy subjects and 12 patients with hypercholesterolemia to 2 high-fat meal sequences to which 25 g olive oil or 40 g walnuts had been added. Both test meals contained 80 g fat and 35% saturated fatty acids, and consumption of each meal was separated by 1 week. Venipunctures and ultrasound measurements of brachial artery endothelial function were performed after fasting and 4 h after test meals. RESULTS: In both study groups, flow-mediated dilation (FMD) was worse after the olive oil meal than after the walnut meal (p = 0.006, time-period interaction). Fasting, but not postprandial, triglyceride concentrations correlated inversely with FMD (r = -0.324; p = 0.024). Flow-independent dilation and plasma ADMA concentrations were unchanged, and the concentration of oxidized low-density lipoproteins decreased (p = 0.051) after either meal. The plasma concentrations of soluble inflammatory cytokines and adhesion molecules decreased (p < 0.01) independently of meal type, except for E-selectin, which decreased more (p = 0.033) after the walnut meal. CONCLUSIONS: Adding walnuts to a high-fat meal acutely improves FMD independently of changes in oxidation, inflammation, or ADMA. Both walnuts and olive oil preserve the protective phenotype of endothelial cells. SN - 1558-3597 UR - https://www.unboundmedicine.com/medline/citation/17045905/Acute_effects_of_high_fat_meals_enriched_with_walnuts_or_olive_oil_on_postprandial_endothelial_function_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0735-1097(06)01912-7 DB - PRIME DP - Unbound Medicine ER -