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Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory.
Life Sci. 2007 Jan 02; 80(4):285-92.LS

Abstract

In the present study, the effects of bilateral injections of dopaminergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol (EtOH) state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of EtOH (0.25, 0.5 and 1 g/kg) dose dependently induced impairment of memory retention. Pre-test administration of EtOH (0.5 g/kg)-induced state-dependent retrieval of the memory acquired under pre-training EtOH (0.5 g/kg) influence. Intra-CA1 administration of the dopamine D(1) receptor agonist, SKF 38393 (0.5, 1 and 2 g/mouse) or the dopamine D(2) receptor agonist, quinpirole (0.25, 0.5 and 1 microg/mouse) alone cannot affect memory retention. While, pre-test intra-CA1 injection of SKF 38393 (2 microg/mouse, intra-CA1) or quinpirole (0.25, 0.5 and 1 microg/mouse, intra-CA1) improved pre-training EtOH (0.5 g/kg)-induced retrieval impairment. Moreover, pre-test administration of SKF 38393 (0.5, 1 and 2 microg/mouse, intra-CA1) or quinpirole (0.5 and 1 microg/mouse, intra-CA1) with an ineffective dose of EtOH (0.25 g/kg) significantly restored the retrieval and induced EtOH state-dependent memory. Furthermore, pre-training injection of the dopamine D(1) receptor antagonist, SCH 23390 (4 microg/mouse), but not the dopamine D(2) receptor antagonist, sulpiride, into the CA1 regions suppressed the learning of a single-trial passive avoidance task. Pre-test intra-CA1 injection of SCH 23390 (2 and 4 microg/mouse, intra-CA1) or sulpiride (2.5 and 5 microg/mouse, intra-CA1) 5 min before the administration of EtOH (0.5 g/kg, i.p.) dose dependently inhibited EtOH state-dependent memory. These findings implicate the involvement of a dorsal hippocampal dopaminergic mechanism in EtOH state-dependent memory and also it can be concluded that there may be a cross-state dependency between EtOH and dopamine.

Authors+Show Affiliations

Rezayof A
School of Biology, University College of Science, University of Tehran, Tehran, Iran.
Motevasseli T
No affiliation info available
Rassouli Y
No affiliation info available
Zarrindast MR
No affiliation info available

MeSH

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepineAnimalsAvoidance LearningCentral Nervous System DepressantsDose-Response Relationship, DrugDrug SynergismEthanolHippocampusInjections, IntraperitonealInjections, IntraventricularMaleMemoryMiceMice, Inbred StrainsQuinpiroleReceptors, Dopamine D1Receptors, Dopamine D2SulpirideTime Factors

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17046026

Citation

Rezayof, Ameneh, et al. "Dorsal Hippocampal Dopamine Receptors Are Involved in Mediating Ethanol State-dependent Memory." Life Sciences, vol. 80, no. 4, 2007, pp. 285-92.
Rezayof A, Motevasseli T, Rassouli Y, et al. Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory. Life Sci. 2007;80(4):285-92.
Rezayof, A., Motevasseli, T., Rassouli, Y., & Zarrindast, M. R. (2007). Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory. Life Sciences, 80(4), 285-92.
Rezayof A, et al. Dorsal Hippocampal Dopamine Receptors Are Involved in Mediating Ethanol State-dependent Memory. Life Sci. 2007 Jan 2;80(4):285-92. PubMed PMID: 17046026.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dorsal hippocampal dopamine receptors are involved in mediating ethanol state-dependent memory. AU - Rezayof,Ameneh, AU - Motevasseli,Tahmineh, AU - Rassouli,Yassaman, AU - Zarrindast,Mohammad-Reza, Y1 - 2006/09/23/ PY - 2006/05/21/received PY - 2006/09/11/revised PY - 2006/09/13/accepted PY - 2006/10/19/pubmed PY - 2007/2/9/medline PY - 2006/10/19/entrez SP - 285 EP - 92 JF - Life sciences JO - Life Sci VL - 80 IS - 4 N2 - In the present study, the effects of bilateral injections of dopaminergic agents into the hippocampal CA1 regions (intra-CA1) on ethanol (EtOH) state-dependent memory were examined in mice. A single-trial step-down passive avoidance task was used for the assessment of memory retention in adult male NMRI mice. Pre-training intra-peritoneal (i.p.) administration of EtOH (0.25, 0.5 and 1 g/kg) dose dependently induced impairment of memory retention. Pre-test administration of EtOH (0.5 g/kg)-induced state-dependent retrieval of the memory acquired under pre-training EtOH (0.5 g/kg) influence. Intra-CA1 administration of the dopamine D(1) receptor agonist, SKF 38393 (0.5, 1 and 2 g/mouse) or the dopamine D(2) receptor agonist, quinpirole (0.25, 0.5 and 1 microg/mouse) alone cannot affect memory retention. While, pre-test intra-CA1 injection of SKF 38393 (2 microg/mouse, intra-CA1) or quinpirole (0.25, 0.5 and 1 microg/mouse, intra-CA1) improved pre-training EtOH (0.5 g/kg)-induced retrieval impairment. Moreover, pre-test administration of SKF 38393 (0.5, 1 and 2 microg/mouse, intra-CA1) or quinpirole (0.5 and 1 microg/mouse, intra-CA1) with an ineffective dose of EtOH (0.25 g/kg) significantly restored the retrieval and induced EtOH state-dependent memory. Furthermore, pre-training injection of the dopamine D(1) receptor antagonist, SCH 23390 (4 microg/mouse), but not the dopamine D(2) receptor antagonist, sulpiride, into the CA1 regions suppressed the learning of a single-trial passive avoidance task. Pre-test intra-CA1 injection of SCH 23390 (2 and 4 microg/mouse, intra-CA1) or sulpiride (2.5 and 5 microg/mouse, intra-CA1) 5 min before the administration of EtOH (0.5 g/kg, i.p.) dose dependently inhibited EtOH state-dependent memory. These findings implicate the involvement of a dorsal hippocampal dopaminergic mechanism in EtOH state-dependent memory and also it can be concluded that there may be a cross-state dependency between EtOH and dopamine. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17046026/Dorsal_hippocampal_dopamine_receptors_are_involved_in_mediating_ethanol_state_dependent_memory_ DB - PRIME DP - Unbound Medicine ER -