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Mesoporous silica material TUD-1 as a drug delivery system.
Int J Pharm. 2007 Feb 22; 331(1):133-8.IJ

Abstract

For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds.

Authors+Show Affiliations

Laboratory of Industrial Physics, Department of Physics, University of Turku, FI-20014 Turku, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17046183

Citation

Heikkilä, T, et al. "Mesoporous Silica Material TUD-1 as a Drug Delivery System." International Journal of Pharmaceutics, vol. 331, no. 1, 2007, pp. 133-8.
Heikkilä T, Salonen J, Tuura J, et al. Mesoporous silica material TUD-1 as a drug delivery system. Int J Pharm. 2007;331(1):133-8.
Heikkilä, T., Salonen, J., Tuura, J., Hamdy, M. S., Mul, G., Kumar, N., Salmi, T., Murzin, D. Y., Laitinen, L., Kaukonen, A. M., Hirvonen, J., & Lehto, V. P. (2007). Mesoporous silica material TUD-1 as a drug delivery system. International Journal of Pharmaceutics, 331(1), 133-8.
Heikkilä T, et al. Mesoporous Silica Material TUD-1 as a Drug Delivery System. Int J Pharm. 2007 Feb 22;331(1):133-8. PubMed PMID: 17046183.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesoporous silica material TUD-1 as a drug delivery system. AU - Heikkilä,T, AU - Salonen,J, AU - Tuura,J, AU - Hamdy,M S, AU - Mul,G, AU - Kumar,N, AU - Salmi,T, AU - Murzin,D Yu, AU - Laitinen,L, AU - Kaukonen,A M, AU - Hirvonen,J, AU - Lehto,V-P, Y1 - 2006/09/19/ PY - 2006/04/26/received PY - 2006/09/11/revised PY - 2006/09/14/accepted PY - 2006/10/19/pubmed PY - 2007/4/6/medline PY - 2006/10/19/entrez SP - 133 EP - 8 JF - International journal of pharmaceutics JO - Int J Pharm VL - 331 IS - 1 N2 - For the first time the feasibility of siliceous mesoporous material TUD-1 (Technische Universiteit Delft) for drug delivery was studied. Model drug, ibuprofen, was adsorbed into TUD-1 mesopores via a soaking procedure. Characterizations with nitrogen adsorption, XRD, TG, HPLC and DSC demonstrated the successful inclusion of ibuprofen into TUD-1 host. The amount of ibuprofen adsorbed into the nanoreservoir of TUD-1 material was higher than reported for other mesoporous silica drug carriers (drug/carrier 49.5 wt.%). Drug release studies in vitro (HBSS buffer pH 5.5) demonstrated a fast and unrestricted liberation of ibuprofen, with 96% released at 210 min of the dissolution assay. The drug dissolution profile of TUD-1 material with the random, foam-like three-dimensional mesopore network and high accessibility to the dissolution medium was found to be much faster (kinetic constant k = 10.7) and more diffusion based (release constant n = 0.64) compared to a mesoporous MCM-41 material with smaller, unidirectional mesopore channels (k = 4.7, n = 0.71). Also, the mesoporous carriers were found to significantly increase the dissolution rate of ibuprofen, when compared to the pure crystalline form of the drug (k = 0.6, n = 0.96). TUD-1 was constituted as a potential drug delivery device with fast release property, with prospective applications in the formulation of poorly soluble drug compounds. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17046183/Mesoporous_silica_material_TUD_1_as_a_drug_delivery_system_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(06)00770-8 DB - PRIME DP - Unbound Medicine ER -