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Melatonin in cancer management: progress and promise.
Cancer Res. 2006 Oct 15; 66(20):9789-93.CR

Abstract

Physiologic and pharmacologic concentrations of the pineal hormone melatonin have shown chemopreventive, oncostatic, and tumor inhibitory effects in a variety of in vitro and in vivo experimental models of neoplasia. Multiple mechanisms have been suggested for the biological effects of melatonin. Not only does melatonin seem to control development alone but also has the potential to increase the efficacy and decrease the side effects of chemotherapy when used in adjuvant settings. This review critically evaluates progress in the ability of melatonin to prevent or reverse cancer development and progression. We also discuss future prospects of the possible development of melatonin as a chemopreventive agent.

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Authors+Show Affiliations

Jung B
Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA.
Ahmad N
No affiliation info available

MeSH

AnimalsAnticarcinogenic AgentsAntineoplastic AgentsClinical Trials as TopicHumansMelatoninNeoplasms

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

17047036

Clinical Trial Links

Circadian as A Prognostic Factor For Radiation Response in Cervical Cancer

Citation

Jung, Brittney, and Nihal Ahmad. "Melatonin in Cancer Management: Progress and Promise." Cancer Research, vol. 66, no. 20, 2006, pp. 9789-93.
Jung B, Ahmad N. Melatonin in cancer management: progress and promise. Cancer Res. 2006;66(20):9789-93.
Jung, B., & Ahmad, N. (2006). Melatonin in cancer management: progress and promise. Cancer Research, 66(20), 9789-93.
Jung B, Ahmad N. Melatonin in Cancer Management: Progress and Promise. Cancer Res. 2006 Oct 15;66(20):9789-93. PubMed PMID: 17047036.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin in cancer management: progress and promise. AU - Jung,Brittney, AU - Ahmad,Nihal, PY - 2006/10/19/pubmed PY - 2006/12/9/medline PY - 2006/10/19/entrez SP - 9789 EP - 93 JF - Cancer research JO - Cancer Res VL - 66 IS - 20 N2 - Physiologic and pharmacologic concentrations of the pineal hormone melatonin have shown chemopreventive, oncostatic, and tumor inhibitory effects in a variety of in vitro and in vivo experimental models of neoplasia. Multiple mechanisms have been suggested for the biological effects of melatonin. Not only does melatonin seem to control development alone but also has the potential to increase the efficacy and decrease the side effects of chemotherapy when used in adjuvant settings. This review critically evaluates progress in the ability of melatonin to prevent or reverse cancer development and progression. We also discuss future prospects of the possible development of melatonin as a chemopreventive agent. SN - 0008-5472 UR - https://www.unboundmedicine.com/medline/citation/17047036/Melatonin_in_cancer_management:_progress_and_promise_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17047036 DB - PRIME DP - Unbound Medicine ER -