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Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation.
J Clin Neurosci. 2006 Nov; 13(9):942-4.JC

Abstract

We report the case of an elderly man of Greek background who presented with progressive cognitive decline and motor parkinsonism on a background of a strong family history of Parkinson's disease. Associated symptoms included visual hallucinations, excessive daytime drowsiness, recurrent falls, orthostatic hypotension and urinary incontinence. His major clinical symptoms and signs fulfilled consensus criteria for a clinical diagnosis of dementia with Lewy bodies. An alpha-synuclein gene mutation analysis for the G209A substitution was positive. We conclude that the alpha-synuclein (G209A) gene mutation genotype should be considered in the differential diagnosis of dementia with Lewy bodies, particularly in patients with European ancestry and a family history of Parkinson's disease.

Authors+Show Affiliations

Department of Aged Care, St George Hospital, Gray St, Kogarah, Sydney, New South Wales 2217, Australia. morfisl@sesahs.nsw.gov.auNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17049244

Citation

Morfis, Litsa, and Dennis John Cordato. "Dementia With Lewy Bodies in an Elderly Greek Male Due to Alpha-synuclein Gene Mutation." Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, vol. 13, no. 9, 2006, pp. 942-4.
Morfis L, Cordato DJ. Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation. J Clin Neurosci. 2006;13(9):942-4.
Morfis, L., & Cordato, D. J. (2006). Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation. Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia, 13(9), 942-4.
Morfis L, Cordato DJ. Dementia With Lewy Bodies in an Elderly Greek Male Due to Alpha-synuclein Gene Mutation. J Clin Neurosci. 2006;13(9):942-4. PubMed PMID: 17049244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dementia with Lewy bodies in an elderly Greek male due to alpha-synuclein gene mutation. AU - Morfis,Litsa, AU - Cordato,Dennis John, Y1 - 2006/10/16/ PY - 2005/07/08/received PY - 2005/11/22/accepted PY - 2006/10/20/pubmed PY - 2007/1/11/medline PY - 2006/10/20/entrez SP - 942 EP - 4 JF - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JO - J Clin Neurosci VL - 13 IS - 9 N2 - We report the case of an elderly man of Greek background who presented with progressive cognitive decline and motor parkinsonism on a background of a strong family history of Parkinson's disease. Associated symptoms included visual hallucinations, excessive daytime drowsiness, recurrent falls, orthostatic hypotension and urinary incontinence. His major clinical symptoms and signs fulfilled consensus criteria for a clinical diagnosis of dementia with Lewy bodies. An alpha-synuclein gene mutation analysis for the G209A substitution was positive. We conclude that the alpha-synuclein (G209A) gene mutation genotype should be considered in the differential diagnosis of dementia with Lewy bodies, particularly in patients with European ancestry and a family history of Parkinson's disease. SN - 0967-5868 UR - https://www.unboundmedicine.com/medline/citation/17049244/Dementia_with_Lewy_bodies_in_an_elderly_Greek_male_due_to_alpha_synuclein_gene_mutation_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0967-5868(06)00421-8 DB - PRIME DP - Unbound Medicine ER -