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Seizures during intracarotid methohexital and amobarbital testing.
Epilepsy Behav. 2007 Feb; 10(1):49-54.EB

Abstract

BACKGROUND

Methohexital and amobarbital have been used as agents for Wada testing in the presurgical evaluation of patients with epilepsy. Previous experience with methohexital as an anesthetic indicates that methohexital may decrease seizure threshold and may trigger seizures.

METHODS

A retrospective chart review of 760 intracarotid amobarbital and methohexital tests was performed to determine the frequency of seizures associated with preoperative intracarotid barbiturate testing for language and memory lateralization.

RESULTS

Sixteen patients (2.1%) who had seizures were found. In 3 patients, seizures occurred prior to barbiturate injection, and in 13, following barbiturate injection. After injection of amobarbital, 4 of 538 patients (0.7%) had a seizure. Nine of 222 patients had a seizure after methohexital injection (4.1%) (P=0.001).

CONCLUSION

Patients with a previous history of epilepsy may be at higher risk for seizures after methohexital injection as compared with amobarbital injection.

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Authors+Show Affiliations

Loddenkemper T
Department of Neurology, Cleveland Clinic, Cleveland, OH, USA. loddent@ccf.org
Möddel G
No affiliation info available
Schuele SU
No affiliation info available
Wyllie E
No affiliation info available
Morris HH
No affiliation info available

MeSH

AdolescentAdultAmobarbitalBarbituratesElectroencephalographyFemaleHumansHypnotics and SedativesInjections, Intra-ArterialLanguageMaleMemoryMethohexitalRetrospective StudiesSeizures

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17049312

Citation

Loddenkemper, Tobias, et al. "Seizures During Intracarotid Methohexital and Amobarbital Testing." Epilepsy & Behavior : E&B, vol. 10, no. 1, 2007, pp. 49-54.
Loddenkemper T, Möddel G, Schuele SU, et al. Seizures during intracarotid methohexital and amobarbital testing. Epilepsy Behav. 2007;10(1):49-54.
Loddenkemper, T., Möddel, G., Schuele, S. U., Wyllie, E., & Morris, H. H. (2007). Seizures during intracarotid methohexital and amobarbital testing. Epilepsy & Behavior : E&B, 10(1), 49-54.
Loddenkemper T, et al. Seizures During Intracarotid Methohexital and Amobarbital Testing. Epilepsy Behav. 2007;10(1):49-54. PubMed PMID: 17049312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Seizures during intracarotid methohexital and amobarbital testing. AU - Loddenkemper,Tobias, AU - Möddel,Gabriel, AU - Schuele,Stephan U, AU - Wyllie,Elaine, AU - Morris,Harold H,3rd Y1 - 2006/10/16/ PY - 2006/08/03/received PY - 2006/08/31/revised PY - 2006/09/02/accepted PY - 2006/10/20/pubmed PY - 2008/8/30/medline PY - 2006/10/20/entrez SP - 49 EP - 54 JF - Epilepsy & behavior : E&B JO - Epilepsy Behav VL - 10 IS - 1 N2 - BACKGROUND: Methohexital and amobarbital have been used as agents for Wada testing in the presurgical evaluation of patients with epilepsy. Previous experience with methohexital as an anesthetic indicates that methohexital may decrease seizure threshold and may trigger seizures. METHODS: A retrospective chart review of 760 intracarotid amobarbital and methohexital tests was performed to determine the frequency of seizures associated with preoperative intracarotid barbiturate testing for language and memory lateralization. RESULTS: Sixteen patients (2.1%) who had seizures were found. In 3 patients, seizures occurred prior to barbiturate injection, and in 13, following barbiturate injection. After injection of amobarbital, 4 of 538 patients (0.7%) had a seizure. Nine of 222 patients had a seizure after methohexital injection (4.1%) (P=0.001). CONCLUSION: Patients with a previous history of epilepsy may be at higher risk for seizures after methohexital injection as compared with amobarbital injection. SN - 1525-5069 UR - https://www.unboundmedicine.com/medline/citation/17049312/Seizures_during_intracarotid_methohexital_and_amobarbital_testing_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1525-5050(06)00346-5 DB - PRIME DP - Unbound Medicine ER -