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Angiostrongylus cantonensis: apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice.
Exp Parasitol. 2007 Mar; 115(3):226-32.EP

Abstract

Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. ICR mice were infected orally with 35 infective larvae and sacrificed at 4-14 days, 25 days or 32 days post infection (dpi) for pathological and immunocytochemical examinations. In the non-treated group, no apoptosis signal was found in the meninges or parenchyma of the brains (4-14 dpi). Only a few apoptotic cells were noticed at 25 dpi (3%) and 32 dpi (10%). In the groups, the animals were given a single dose of mebendazole (20 mg/kg, per os at various times) or injections of interleukin 12 (IL-12) (10 ng/daily, intraperitoneally), all the animals were sacrificed at 14 dpi; the number of apoptotic cells was increased (17-21%). In the group that received a single dose of mebendazole (4 dpi) in combination with IL-12 injections (4-13 dpi), mild meningitis was observed, and most of the infiltrated inflammatory cells were in the apoptotic program (55%). Taken together, apoptosis of the inflammatory cells (most were eosinophils) could be induced when the infected mice were treated with mebendazole or/and IL-12.

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Authors+Show Affiliations

Chuang CC
Section of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chen CW
No affiliation info available
Fan CK
No affiliation info available
Su KE
No affiliation info available
Tsai YT
No affiliation info available
Chen CL
No affiliation info available
Du WY
No affiliation info available

MeSH

Adjuvants, ImmunologicAngiostrongylus cantonensisAnimalsAntinematodal AgentsApoptosisBiomphalariaBrainCaspase 3Drug Therapy, CombinationEosinophiliaImmunohistochemistryIn Situ Nick-End LabelingInterleukin-12MaleMebendazoleMeningitisMeningoencephalitisMiceMice, Inbred ICRProto-Oncogene Proteins c-aktRatsRats, WistarStrongylida Infections

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17049518

Citation

Chuang, Chih-Cheng, et al. "Angiostrongylus Cantonensis: Apoptosis of Inflammatory Cells Induced By Treatment With Mebendazole Or/and Interleukin 12 in Mice." Experimental Parasitology, vol. 115, no. 3, 2007, pp. 226-32.
Chuang CC, Chen CW, Fan CK, et al. Angiostrongylus cantonensis: apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice. Exp Parasitol. 2007;115(3):226-32.
Chuang, C. C., Chen, C. W., Fan, C. K., Su, K. E., Tsai, Y. T., Chen, C. L., & Du, W. Y. (2007). Angiostrongylus cantonensis: apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice. Experimental Parasitology, 115(3), 226-32.
Chuang CC, et al. Angiostrongylus Cantonensis: Apoptosis of Inflammatory Cells Induced By Treatment With Mebendazole Or/and Interleukin 12 in Mice. Exp Parasitol. 2007;115(3):226-32. PubMed PMID: 17049518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Angiostrongylus cantonensis: apoptosis of inflammatory cells induced by treatment with mebendazole or/and interleukin 12 in mice. AU - Chuang,Chih-Cheng, AU - Chen,Chi-Wu, AU - Fan,Chia-Kwung, AU - Su,Kua-Eyre, AU - Tsai,Yueh-Ting, AU - Chen,Chih-Li, AU - Du,Wen-Yuan, Y1 - 2006/10/17/ PY - 2006/02/21/received PY - 2006/08/20/revised PY - 2006/09/01/accepted PY - 2006/10/20/pubmed PY - 2007/1/24/medline PY - 2006/10/20/entrez SP - 226 EP - 32 JF - Experimental parasitology JO - Exp Parasitol VL - 115 IS - 3 N2 - Angiostrongylus cantonensis is the major cause of human eosinophilic meningoencephalitis. ICR mice were infected orally with 35 infective larvae and sacrificed at 4-14 days, 25 days or 32 days post infection (dpi) for pathological and immunocytochemical examinations. In the non-treated group, no apoptosis signal was found in the meninges or parenchyma of the brains (4-14 dpi). Only a few apoptotic cells were noticed at 25 dpi (3%) and 32 dpi (10%). In the groups, the animals were given a single dose of mebendazole (20 mg/kg, per os at various times) or injections of interleukin 12 (IL-12) (10 ng/daily, intraperitoneally), all the animals were sacrificed at 14 dpi; the number of apoptotic cells was increased (17-21%). In the group that received a single dose of mebendazole (4 dpi) in combination with IL-12 injections (4-13 dpi), mild meningitis was observed, and most of the infiltrated inflammatory cells were in the apoptotic program (55%). Taken together, apoptosis of the inflammatory cells (most were eosinophils) could be induced when the infected mice were treated with mebendazole or/and IL-12. SN - 0014-4894 UR - https://www.unboundmedicine.com/medline/citation/17049518/Angiostrongylus_cantonensis:_apoptosis_of_inflammatory_cells_induced_by_treatment_with_mebendazole_or/and_interleukin_12_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(06)00210-4 DB - PRIME DP - Unbound Medicine ER -