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Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age.
J Asthma. 2006 Oct; 43(8):633-8.JA

Abstract

STUDY OBJECTIVE

To investigate the early determinants and characteristics of different phenotypes of wheeze in children on the basis of questionnaire data, lung function, and prick tests.

DESIGN

Cross-sectional survey. Setting. Rome and Fiumicino municipalities in Lazio region, Italy, within the ISAAC phase II project.

SUBJECTS

Sample of 2107 9-11 year old schoolchildren (response rate 83.5%).

RESULTS

We divided children into four mutually exclusive groups according to onset of wheeze: 154 early transient (birth to age 2), 51 persistent (birth to age 2 and current), 66 late onset (current only), and 1,446 control subjects (no early or current wheeze). Logistic regression models have shown that a family history of asthma and allergies is strongly associated with persistent and late onset wheezing; exposure to parental smoking--both during pregnancy and during the child's first year of life--is related to persistent wheezing; all children with wheezing show a significantly greater risk to have current respiratory symptoms other than wheeze compared with control subjects; current allergic rhinoconjunctivitis symptoms and atopy are related with both persistent and late onset wheeze. Multiple linear regression models show that forced expiratory rates at 25% to 75% of vital capacity (FEF25-75) and the ratio between forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) are significantly lower both in early transient (-305 mL/s, -1.7%) and persistent (-298 mL/s, -3.2%) wheezers; FEV1/FVC is significantly reduced in late onset wheezers too (-2.0%).

CONCLUSIONS

The strength of the association of family history and exposure to parental smoking varies with the three wheezing phenotypes. Moreover, early, persistent and late onset wheezers have different clinical characteristics in terms of their respiratory health and atopic status.

Authors+Show Affiliations

Department of Epidemiology, Rome E Local Health Authority, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17050231

Citation

De Sario, Manuela, et al. "Characteristics of Early Transient, Persistent, and Late Onset Wheezers at 9 to 11 Years of Age." The Journal of Asthma : Official Journal of the Association for the Care of Asthma, vol. 43, no. 8, 2006, pp. 633-8.
De Sario M, Di Domenicantonio R, Corbo G, et al. Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age. J Asthma. 2006;43(8):633-8.
De Sario, M., Di Domenicantonio, R., Corbo, G., Forastiere, F., Pistelli, R., Rusconi, F., Sammarro, S., Serra, M. G., Compagnucci, P., & Perucci, C. A. (2006). Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age. The Journal of Asthma : Official Journal of the Association for the Care of Asthma, 43(8), 633-8.
De Sario M, et al. Characteristics of Early Transient, Persistent, and Late Onset Wheezers at 9 to 11 Years of Age. J Asthma. 2006;43(8):633-8. PubMed PMID: 17050231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characteristics of early transient, persistent, and late onset wheezers at 9 to 11 years of age. AU - De Sario,Manuela, AU - Di Domenicantonio,Riccardo, AU - Corbo,Giuseppe, AU - Forastiere,Francesco, AU - Pistelli,Riccardo, AU - Rusconi,Franca, AU - Sammarro,Sandra, AU - Serra,Maria Grazia, AU - Compagnucci,Patrizia, AU - Perucci,Carlo A, PY - 2006/10/20/pubmed PY - 2006/12/9/medline PY - 2006/10/20/entrez SP - 633 EP - 8 JF - The Journal of asthma : official journal of the Association for the Care of Asthma JO - J Asthma VL - 43 IS - 8 N2 - STUDY OBJECTIVE: To investigate the early determinants and characteristics of different phenotypes of wheeze in children on the basis of questionnaire data, lung function, and prick tests. DESIGN: Cross-sectional survey. Setting. Rome and Fiumicino municipalities in Lazio region, Italy, within the ISAAC phase II project. SUBJECTS: Sample of 2107 9-11 year old schoolchildren (response rate 83.5%). RESULTS: We divided children into four mutually exclusive groups according to onset of wheeze: 154 early transient (birth to age 2), 51 persistent (birth to age 2 and current), 66 late onset (current only), and 1,446 control subjects (no early or current wheeze). Logistic regression models have shown that a family history of asthma and allergies is strongly associated with persistent and late onset wheezing; exposure to parental smoking--both during pregnancy and during the child's first year of life--is related to persistent wheezing; all children with wheezing show a significantly greater risk to have current respiratory symptoms other than wheeze compared with control subjects; current allergic rhinoconjunctivitis symptoms and atopy are related with both persistent and late onset wheeze. Multiple linear regression models show that forced expiratory rates at 25% to 75% of vital capacity (FEF25-75) and the ratio between forced expiratory volume in 1 second and forced vital capacity (FEV1/FVC) are significantly lower both in early transient (-305 mL/s, -1.7%) and persistent (-298 mL/s, -3.2%) wheezers; FEV1/FVC is significantly reduced in late onset wheezers too (-2.0%). CONCLUSIONS: The strength of the association of family history and exposure to parental smoking varies with the three wheezing phenotypes. Moreover, early, persistent and late onset wheezers have different clinical characteristics in terms of their respiratory health and atopic status. SN - 0277-0903 UR - https://www.unboundmedicine.com/medline/citation/17050231/Characteristics_of_early_transient_persistent_and_late_onset_wheezers_at_9_to_11_years_of_age_ L2 - https://www.tandfonline.com/doi/full/10.1080/02770900600878974 DB - PRIME DP - Unbound Medicine ER -