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Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking.
Eur Respir J. 2007 Jan; 29(1):42-50.ER

Abstract

In contrast to the effects of cigarette smoke on T-lymphocyte subsets in the airways, it has not yet been determined whether smoking has immunomodulatory effects on surface antigens of peripheral blood T-lymphocytes and, if that is the case, whether these effects differ in smokers with and without chronic obstructive pulmonary disease (COPD). The present authors have, therefore, examined the expression of the surface activation marker CD28, the levels of cytotoxic effector lymphocytes (CD27-/CD45RA+) and the expression of the lung type (Tc)1-specific chemokine receptor CXCR(3)+ on peripheral blood CD8+ T-lymphocytes. The present authors have also studied the chemotactic activity of CD8+ T-lymphocytes on monocyte chemotactic protein (MCP)-1 and compared 13 nonsmoking controls, 12 smokers with COPD and 14 smokers without airflow limitation. There was a decrease in the total count of CD8+ T-cells and an increase in the CD4+/CD8+ ratio in smokers with COPD compared with smokers without COPD and controls. Expression of the Tc1-specific chemokine receptor CXCR(3)+ by CD8+ T-cells was increased in smokers with COPD compared with smokers without COPD and controls. The expression of activated and of cytotoxic effector CD8+ T-cells in smokers with and without COPD showed an increase compared with controls. CD8+ T-cells from smokers with and without COPD showed a decrease in chemotactic activity to MCP-1 compared with controls. In conclusion, chronic obstructive pulmonary disease may be a systemic immunomodulatory disease associated with the modification of surface antigens in blood CD8+ T-lymphocytes.

Authors+Show Affiliations

Department of Pneumology, Clinic III for Internal Medicine, University of Cologne, Cologne, Germany. andrea.koch@uni-koeln.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17050556

Citation

Koch, A, et al. "Modification of Surface Antigens in Blood CD8+ T-lymphocytes in COPD: Effects of Smoking." The European Respiratory Journal, vol. 29, no. 1, 2007, pp. 42-50.
Koch A, Gaczkowski M, Sturton G, et al. Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. Eur Respir J. 2007;29(1):42-50.
Koch, A., Gaczkowski, M., Sturton, G., Staib, P., Schinköthe, T., Klein, E., Rubbert, A., Bacon, K., Wassermann, K., & Erdmann, E. (2007). Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. The European Respiratory Journal, 29(1), 42-50.
Koch A, et al. Modification of Surface Antigens in Blood CD8+ T-lymphocytes in COPD: Effects of Smoking. Eur Respir J. 2007;29(1):42-50. PubMed PMID: 17050556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. AU - Koch,A, AU - Gaczkowski,M, AU - Sturton,G, AU - Staib,P, AU - Schinköthe,T, AU - Klein,E, AU - Rubbert,A, AU - Bacon,K, AU - Wassermann,K, AU - Erdmann,E, Y1 - 2006/10/18/ PY - 2006/10/20/pubmed PY - 2007/3/21/medline PY - 2006/10/20/entrez SP - 42 EP - 50 JF - The European respiratory journal JO - Eur Respir J VL - 29 IS - 1 N2 - In contrast to the effects of cigarette smoke on T-lymphocyte subsets in the airways, it has not yet been determined whether smoking has immunomodulatory effects on surface antigens of peripheral blood T-lymphocytes and, if that is the case, whether these effects differ in smokers with and without chronic obstructive pulmonary disease (COPD). The present authors have, therefore, examined the expression of the surface activation marker CD28, the levels of cytotoxic effector lymphocytes (CD27-/CD45RA+) and the expression of the lung type (Tc)1-specific chemokine receptor CXCR(3)+ on peripheral blood CD8+ T-lymphocytes. The present authors have also studied the chemotactic activity of CD8+ T-lymphocytes on monocyte chemotactic protein (MCP)-1 and compared 13 nonsmoking controls, 12 smokers with COPD and 14 smokers without airflow limitation. There was a decrease in the total count of CD8+ T-cells and an increase in the CD4+/CD8+ ratio in smokers with COPD compared with smokers without COPD and controls. Expression of the Tc1-specific chemokine receptor CXCR(3)+ by CD8+ T-cells was increased in smokers with COPD compared with smokers without COPD and controls. The expression of activated and of cytotoxic effector CD8+ T-cells in smokers with and without COPD showed an increase compared with controls. CD8+ T-cells from smokers with and without COPD showed a decrease in chemotactic activity to MCP-1 compared with controls. In conclusion, chronic obstructive pulmonary disease may be a systemic immunomodulatory disease associated with the modification of surface antigens in blood CD8+ T-lymphocytes. SN - 0903-1936 UR - https://www.unboundmedicine.com/medline/citation/17050556/Modification_of_surface_antigens_in_blood_CD8+_T_lymphocytes_in_COPD:_effects_of_smoking_ L2 - http://erj.ersjournals.com/cgi/pmidlookup?view=long&pmid=17050556 DB - PRIME DP - Unbound Medicine ER -