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Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases.
Nature. 2006 Oct 19; 443(7113):787-95.Nat

Abstract

Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis. Moreover, an impressive number of disease-specific proteins interact with mitochondria. Thus, therapies targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise.

Authors+Show Affiliations

Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Room F-610, 525 East 68th Street, New York 10021, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17051205

Citation

Lin, Michael T., and M Flint Beal. "Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases." Nature, vol. 443, no. 7113, 2006, pp. 787-95.
Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787-95.
Lin, M. T., & Beal, M. F. (2006). Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature, 443(7113), 787-95.
Lin MT, Beal MF. Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases. Nature. 2006 Oct 19;443(7113):787-95. PubMed PMID: 17051205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. AU - Lin,Michael T, AU - Beal,M Flint, PY - 2006/10/20/pubmed PY - 2006/12/9/medline PY - 2006/10/20/entrez SP - 787 EP - 95 JF - Nature JO - Nature VL - 443 IS - 7113 N2 - Many lines of evidence suggest that mitochondria have a central role in ageing-related neurodegenerative diseases. Mitochondria are critical regulators of cell death, a key feature of neurodegeneration. Mutations in mitochondrial DNA and oxidative stress both contribute to ageing, which is the greatest risk factor for neurodegenerative diseases. In all major examples of these diseases there is strong evidence that mitochondrial dysfunction occurs early and acts causally in disease pathogenesis. Moreover, an impressive number of disease-specific proteins interact with mitochondria. Thus, therapies targeting basic mitochondrial processes, such as energy metabolism or free-radical generation, or specific interactions of disease-related proteins with mitochondria, hold great promise. SN - 1476-4687 UR - https://www.unboundmedicine.com/medline/citation/17051205/Mitochondrial_dysfunction_and_oxidative_stress_in_neurodegenerative_diseases_ L2 - https://doi.org/10.1038/nature05292 DB - PRIME DP - Unbound Medicine ER -