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Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit.
Eur J Pediatr 2007; 166(4):319-25EJ

Abstract

Hospital acquired infections including staphylococcal species are common in neonatal intensive care units. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was recently observed in our unit. The clinical and laboratory characteristics of all neonates with Staphylococcus aureus bacteremia during an 11-year period were retrospectively reviewed. Three groups of patients were compared: 1. Patients with CA-MRSA defined as MRSA-resistant only to beta-lactams, but sensitive to all other antibiotic groups and carried SCCmec IV. 2. Patients with multi-drug-resistant (MDR)-MRSA and 3. Patients with MSSA (methicillin-sensitive S. aureus). Forty-three neonates with documented S. aureus bacteremia were included. Of these 41 were preterm babies. Eleven infants had CA-MRSA, 20 had MDR-MRSA and 12 had MSSA bacteremia, the Panton-Valentine-Leukocidine gene (pvl-gene) was not present in any of these strains. Risk factors, clinical manifestations and laboratory tests were similar in all three groups studied. Although neonates infected with CA-MRSA were more premature and had more related diseases, the mortality rate was similar in all groups (9.1% in the CA-MRSA group). Skin infections, osteomyelitis or pneumatocele were not observed more frequently in the CA-MRSA group. We did not find significant differences in risk factors or outcomes in neonates in the three groups. One possible explanation for this observation is that the CA-MRSA outbreak strain did not contain the pvl-gene, which has been suggested to be a significant virulence factor.

Authors+Show Affiliations

Neonatal Department, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. kuint-j@sheba.health.gov.ilNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17051356

Citation

Kuint, Jacob, et al. "Comparison of Community-acquired Methicillin-resistant Staphylococcus Aureus Bacteremia to Other Staphylococcal Species in a Neonatal Intensive Care Unit." European Journal of Pediatrics, vol. 166, no. 4, 2007, pp. 319-25.
Kuint J, Barzilai A, Regev-Yochay G, et al. Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. Eur J Pediatr. 2007;166(4):319-25.
Kuint, J., Barzilai, A., Regev-Yochay, G., Rubinstein, E., Keller, N., & Maayan-Metzger, A. (2007). Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. European Journal of Pediatrics, 166(4), pp. 319-25.
Kuint J, et al. Comparison of Community-acquired Methicillin-resistant Staphylococcus Aureus Bacteremia to Other Staphylococcal Species in a Neonatal Intensive Care Unit. Eur J Pediatr. 2007;166(4):319-25. PubMed PMID: 17051356.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of community-acquired methicillin-resistant Staphylococcus aureus bacteremia to other staphylococcal species in a neonatal intensive care unit. AU - Kuint,Jacob, AU - Barzilai,Asher, AU - Regev-Yochay,Gili, AU - Rubinstein,Ethan, AU - Keller,Nati, AU - Maayan-Metzger,Ayala, Y1 - 2006/10/19/ PY - 2006/03/21/received PY - 2006/06/20/accepted PY - 2006/06/13/revised PY - 2006/10/20/pubmed PY - 2007/12/6/medline PY - 2006/10/20/entrez SP - 319 EP - 25 JF - European journal of pediatrics JO - Eur. J. Pediatr. VL - 166 IS - 4 N2 - Hospital acquired infections including staphylococcal species are common in neonatal intensive care units. Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) was recently observed in our unit. The clinical and laboratory characteristics of all neonates with Staphylococcus aureus bacteremia during an 11-year period were retrospectively reviewed. Three groups of patients were compared: 1. Patients with CA-MRSA defined as MRSA-resistant only to beta-lactams, but sensitive to all other antibiotic groups and carried SCCmec IV. 2. Patients with multi-drug-resistant (MDR)-MRSA and 3. Patients with MSSA (methicillin-sensitive S. aureus). Forty-three neonates with documented S. aureus bacteremia were included. Of these 41 were preterm babies. Eleven infants had CA-MRSA, 20 had MDR-MRSA and 12 had MSSA bacteremia, the Panton-Valentine-Leukocidine gene (pvl-gene) was not present in any of these strains. Risk factors, clinical manifestations and laboratory tests were similar in all three groups studied. Although neonates infected with CA-MRSA were more premature and had more related diseases, the mortality rate was similar in all groups (9.1% in the CA-MRSA group). Skin infections, osteomyelitis or pneumatocele were not observed more frequently in the CA-MRSA group. We did not find significant differences in risk factors or outcomes in neonates in the three groups. One possible explanation for this observation is that the CA-MRSA outbreak strain did not contain the pvl-gene, which has been suggested to be a significant virulence factor. SN - 0340-6199 UR - https://www.unboundmedicine.com/medline/citation/17051356/Comparison_of_community_acquired_methicillin_resistant_Staphylococcus_aureus_bacteremia_to_other_staphylococcal_species_in_a_neonatal_intensive_care_unit_ L2 - https://dx.doi.org/10.1007/s00431-006-0238-5 DB - PRIME DP - Unbound Medicine ER -