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Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis.
Respirology. 2006 Nov; 11(6):708-14.R

Abstract

OBJECTIVE AND BACKGROUND

Interferon gamma-inducible protein (IP)-10 and epithelial neutrophil-activating peptide (ENA)-78 belong to the CXC chemokine family and are important factors in inflammatory lung diseases. In sarcoidosis, the potential role of IP-10 to regulate the migration and activation of T-cells towards sites of sarcoid activity has been suggested.

METHODS

In this study, the concentrations of IP-10 and ENA-78 in the serum and BAL fluid of patients with different stages of active pulmonary sarcoidosis (n=41) and healthy subjects (n=12) were measured by enzyme-linked immunosorbent assay to evaluate the contribution of these CXC chemokines to this disease.

RESULTS

Serum and BAL fluid concentrations of IP-10 and BAL fluid levels of ENA-78 in patients with sarcoidosis were significantly higher than those in control subjects. The serum levels of IP-10 were significantly increased only in patients with stages I and II sarcoidosis, while BAL fluid levels of ENA-78 were increased only in stage III sarcoidosis. In addition, serum concentrations of IP-10 were elevated in patients with extrapulmonary lesions compared with those without such lesions. In patients with sarcoidosis, IP-10 concentrations in BAL fluid correlated with lymphocyte proportions in BAL fluid.

CONCLUSION

IP-10 may play an important role in regulating lymphocytes into the lung and that ENA-78 may be associated with lung parenchymal disease in pulmonary sarcoidosis.

Authors+Show Affiliations

Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17052298

Citation

Sugiyama, Kanako, et al. "Elevated Levels of Interferon Gamma-inducible Protein-10 and Epithelial Neutrophil-activating Peptide-78 in Patients With Pulmonary Sarcoidosis." Respirology (Carlton, Vic.), vol. 11, no. 6, 2006, pp. 708-14.
Sugiyama K, Mukae H, Ishii H, et al. Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis. Respirology. 2006;11(6):708-14.
Sugiyama, K., Mukae, H., Ishii, H., Kakugawa, T., Ishimoto, H., Nakayama, S., Shirai, R., Fujii, T., Mizuta, Y., & Kohno, S. (2006). Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis. Respirology (Carlton, Vic.), 11(6), 708-14.
Sugiyama K, et al. Elevated Levels of Interferon Gamma-inducible Protein-10 and Epithelial Neutrophil-activating Peptide-78 in Patients With Pulmonary Sarcoidosis. Respirology. 2006;11(6):708-14. PubMed PMID: 17052298.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated levels of interferon gamma-inducible protein-10 and epithelial neutrophil-activating peptide-78 in patients with pulmonary sarcoidosis. AU - Sugiyama,Kanako, AU - Mukae,Hiroshi, AU - Ishii,Hiroshi, AU - Kakugawa,Tomoyuki, AU - Ishimoto,Hiroshi, AU - Nakayama,Seiko, AU - Shirai,Ryo, AU - Fujii,Takeshi, AU - Mizuta,Yohei, AU - Kohno,Shigeru, PY - 2006/10/21/pubmed PY - 2007/1/24/medline PY - 2006/10/21/entrez SP - 708 EP - 14 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 11 IS - 6 N2 - OBJECTIVE AND BACKGROUND: Interferon gamma-inducible protein (IP)-10 and epithelial neutrophil-activating peptide (ENA)-78 belong to the CXC chemokine family and are important factors in inflammatory lung diseases. In sarcoidosis, the potential role of IP-10 to regulate the migration and activation of T-cells towards sites of sarcoid activity has been suggested. METHODS: In this study, the concentrations of IP-10 and ENA-78 in the serum and BAL fluid of patients with different stages of active pulmonary sarcoidosis (n=41) and healthy subjects (n=12) were measured by enzyme-linked immunosorbent assay to evaluate the contribution of these CXC chemokines to this disease. RESULTS: Serum and BAL fluid concentrations of IP-10 and BAL fluid levels of ENA-78 in patients with sarcoidosis were significantly higher than those in control subjects. The serum levels of IP-10 were significantly increased only in patients with stages I and II sarcoidosis, while BAL fluid levels of ENA-78 were increased only in stage III sarcoidosis. In addition, serum concentrations of IP-10 were elevated in patients with extrapulmonary lesions compared with those without such lesions. In patients with sarcoidosis, IP-10 concentrations in BAL fluid correlated with lymphocyte proportions in BAL fluid. CONCLUSION: IP-10 may play an important role in regulating lymphocytes into the lung and that ENA-78 may be associated with lung parenchymal disease in pulmonary sarcoidosis. SN - 1323-7799 UR - https://www.unboundmedicine.com/medline/citation/17052298/Elevated_levels_of_interferon_gamma_inducible_protein_10_and_epithelial_neutrophil_activating_peptide_78_in_patients_with_pulmonary_sarcoidosis_ L2 - https://doi.org/10.1111/j.1440-1843.2006.00933.x DB - PRIME DP - Unbound Medicine ER -