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The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder.
J Psychiatr Res. 2007 Apr-Jun; 41(3-4):255-64.JP

Abstract

Individuals with bipolar disorder are at increased risk for suicide attempts and completion. Although anxiety may be a modifiable suicide risk factor among bipolar patients, anxiety disorder comorbidity has not been highlighted as critical in identification of high-risk individuals nor has its treatment been integrated into suicide prevention strategies. In this study, ancillary to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), 120 outpatients with bipolar disorder completed detailed assessment of suicidal ideation and behaviors. We examined the association of current and lifetime comorbid anxiety disorders with suicidal ideation and behaviors univariately and with adjustment for potential confounders in regression models. Lifetime anxiety disorders were associated with a more than doubling of the odds of a past suicide attempt, and current anxiety comorbidity was associated with a more than doubling of the odds of current suicidal ideation. Individuals with current anxiety disorders had more severe suicidal ideation, a greater belief suicide would provide relief, and a higher expectancy of future suicidal behaviors. However, some of these associations appeared to be better accounted for by measures of bipolar severity including an earlier age at bipolar onset and a lack of current bipolar recovery. Comorbid anxiety disorders may play a role in characteristics of bipolar disorder that then elevate risk for suicidal ideation and attempts. While further research is needed to establish the precise nature of these associations, our data support that the presence of comorbid anxiety disorders in individuals with bipolar disorder should trigger careful clinical assessment of suicide risk.

Authors+Show Affiliations

Department of Psychiatry, Center for Anxiety and Traumatic Stress Disorders, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Suite 2200, Boston, MA 02114, USA. NSIMON@Partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17052730

Citation

Simon, Naomi M., et al. "The Association of Comorbid Anxiety Disorders With Suicide Attempts and Suicidal Ideation in Outpatients With Bipolar Disorder." Journal of Psychiatric Research, vol. 41, no. 3-4, 2007, pp. 255-64.
Simon NM, Zalta AK, Otto MW, et al. The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder. J Psychiatr Res. 2007;41(3-4):255-64.
Simon, N. M., Zalta, A. K., Otto, M. W., Ostacher, M. J., Fischmann, D., Chow, C. W., Thompson, E. H., Stevens, J. C., Demopulos, C. M., Nierenberg, A. A., & Pollack, M. H. (2007). The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder. Journal of Psychiatric Research, 41(3-4), 255-64.
Simon NM, et al. The Association of Comorbid Anxiety Disorders With Suicide Attempts and Suicidal Ideation in Outpatients With Bipolar Disorder. J Psychiatr Res. 2007 Apr-Jun;41(3-4):255-64. PubMed PMID: 17052730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The association of comorbid anxiety disorders with suicide attempts and suicidal ideation in outpatients with bipolar disorder. AU - Simon,Naomi M, AU - Zalta,Alyson K, AU - Otto,Michael W, AU - Ostacher,Michael J, AU - Fischmann,Diana, AU - Chow,Candice W, AU - Thompson,Elizabeth H, AU - Stevens,Julie C, AU - Demopulos,Christina M, AU - Nierenberg,Andrew A, AU - Pollack,Mark H, Y1 - 2006/10/18/ PY - 2006/01/06/received PY - 2006/08/11/revised PY - 2006/08/15/accepted PY - 2006/10/21/pubmed PY - 2007/3/22/medline PY - 2006/10/21/entrez SP - 255 EP - 64 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 41 IS - 3-4 N2 - Individuals with bipolar disorder are at increased risk for suicide attempts and completion. Although anxiety may be a modifiable suicide risk factor among bipolar patients, anxiety disorder comorbidity has not been highlighted as critical in identification of high-risk individuals nor has its treatment been integrated into suicide prevention strategies. In this study, ancillary to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD), 120 outpatients with bipolar disorder completed detailed assessment of suicidal ideation and behaviors. We examined the association of current and lifetime comorbid anxiety disorders with suicidal ideation and behaviors univariately and with adjustment for potential confounders in regression models. Lifetime anxiety disorders were associated with a more than doubling of the odds of a past suicide attempt, and current anxiety comorbidity was associated with a more than doubling of the odds of current suicidal ideation. Individuals with current anxiety disorders had more severe suicidal ideation, a greater belief suicide would provide relief, and a higher expectancy of future suicidal behaviors. However, some of these associations appeared to be better accounted for by measures of bipolar severity including an earlier age at bipolar onset and a lack of current bipolar recovery. Comorbid anxiety disorders may play a role in characteristics of bipolar disorder that then elevate risk for suicidal ideation and attempts. While further research is needed to establish the precise nature of these associations, our data support that the presence of comorbid anxiety disorders in individuals with bipolar disorder should trigger careful clinical assessment of suicide risk. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/17052730/The_association_of_comorbid_anxiety_disorders_with_suicide_attempts_and_suicidal_ideation_in_outpatients_with_bipolar_disorder_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(06)00173-7 DB - PRIME DP - Unbound Medicine ER -