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Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies?
Curr Opin Clin Nutr Metab Care. 2006 Nov; 9(6):722-7.CO

Abstract

PURPOSE OF REVIEW

Lycopene-rich foods such as fresh tomatoes and tomato products are discussed as potential effectors in the prevention and therapy of prostate cancer. This review provides an overview on the efficacy of supplementation with tomatoes, tomato products and lycopene on appropriate surrogate endpoint biomarkers such as DNA damage and metabolites of the insulin-like growth factor pathway in healthy individuals and prostate cancer patients.

RECENT FINDINGS

Intervention studies show that the daily consumption of one serving of tomatoes or tomato products, but not supplementation with lycopene alone, increases the resistance of mononuclear leukocytes against DNA strand breaks induced by reactive oxygen species in healthy volunteers. Data from clinical trials with prostate cancer patients are scarce and contradictory. There is a paucity of reliable data on DNA damage in prostate tissue.

SUMMARY

Increasing evidence suggests that a single serving of tomatoes or tomato products ingested daily may contribute to protect from DNA damage. As DNA damage seems to be involved in the pathogenesis of prostate cancer, the regular ingestion of tomatoes or tomato products might prevent the disease. Further well-designed studies are necessary to establish the role of tomatoes and tomato products in the prevention and therapy of prostate cancer.

Authors+Show Affiliations

Department of Food and Nutrition Sciences-Nutrition Physiology, University of Bonn, Endenicher Allee 11-13, 53115 Bonn, Germany. ellinger@uni-bonn.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17053426

Citation

Ellinger, Sabine, et al. "Tomatoes, Tomato Products and Lycopene in the Prevention and Treatment of Prostate Cancer: Do We Have the Evidence From Intervention Studies?" Current Opinion in Clinical Nutrition and Metabolic Care, vol. 9, no. 6, 2006, pp. 722-7.
Ellinger S, Ellinger J, Stehle P. Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies? Curr Opin Clin Nutr Metab Care. 2006;9(6):722-7.
Ellinger, S., Ellinger, J., & Stehle, P. (2006). Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies? Current Opinion in Clinical Nutrition and Metabolic Care, 9(6), 722-7.
Ellinger S, Ellinger J, Stehle P. Tomatoes, Tomato Products and Lycopene in the Prevention and Treatment of Prostate Cancer: Do We Have the Evidence From Intervention Studies. Curr Opin Clin Nutr Metab Care. 2006;9(6):722-7. PubMed PMID: 17053426.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tomatoes, tomato products and lycopene in the prevention and treatment of prostate cancer: do we have the evidence from intervention studies? AU - Ellinger,Sabine, AU - Ellinger,Jörg, AU - Stehle,Peter, PY - 2006/10/21/pubmed PY - 2007/1/24/medline PY - 2006/10/21/entrez SP - 722 EP - 7 JF - Current opinion in clinical nutrition and metabolic care JO - Curr Opin Clin Nutr Metab Care VL - 9 IS - 6 N2 - PURPOSE OF REVIEW: Lycopene-rich foods such as fresh tomatoes and tomato products are discussed as potential effectors in the prevention and therapy of prostate cancer. This review provides an overview on the efficacy of supplementation with tomatoes, tomato products and lycopene on appropriate surrogate endpoint biomarkers such as DNA damage and metabolites of the insulin-like growth factor pathway in healthy individuals and prostate cancer patients. RECENT FINDINGS: Intervention studies show that the daily consumption of one serving of tomatoes or tomato products, but not supplementation with lycopene alone, increases the resistance of mononuclear leukocytes against DNA strand breaks induced by reactive oxygen species in healthy volunteers. Data from clinical trials with prostate cancer patients are scarce and contradictory. There is a paucity of reliable data on DNA damage in prostate tissue. SUMMARY: Increasing evidence suggests that a single serving of tomatoes or tomato products ingested daily may contribute to protect from DNA damage. As DNA damage seems to be involved in the pathogenesis of prostate cancer, the regular ingestion of tomatoes or tomato products might prevent the disease. Further well-designed studies are necessary to establish the role of tomatoes and tomato products in the prevention and therapy of prostate cancer. SN - 1363-1950 UR - https://www.unboundmedicine.com/medline/citation/17053426/Tomatoes_tomato_products_and_lycopene_in_the_prevention_and_treatment_of_prostate_cancer:_do_we_have_the_evidence_from_intervention_studies L2 - http://dx.doi.org/10.1097/01.mco.0000247470.64532.34 DB - PRIME DP - Unbound Medicine ER -