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Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa.
J Psychiatr Res 2007; 41(10):814-20JP

Abstract

BACKGROUND

In humans, ghrelin has been found to stimulate appetite while PYY3-36 to reduce it; these orexigenic and anorexigenic peptides play significant roles in appetite control. We investigated pre- and postprandial responses of ghrelin and PYY in anorexia nervosa (AN) and the influence of weight gain.

METHODS

Plasma ghrelin, PYY3-36, glucose and insulin responses after ingestion of a 400 kcal standard meal were measured in 14 patients with restricting type of AN and 12 controls. The AN patients were evaluated before therapy and after inpatient therapy. Psychometry was performed by the use of Eating Disorders Inventory.

RESULTS

Ghrelin was suppressed during the meal test, while PYY3-36 was increased in all of the groups. Before therapy, AN patients had significantly increased levels of ghrelin and PYY3-36 compared to the control (P<0.01). After therapeutic intervention, as the nutritional status of AN patients improved, the secretion of these hormones were increased (P<0.05), but not normalized as in psychological testing. In contrast, insulin and glucose responses were normalized after inpatient therapy.

CONCLUSIONS

We found that both ghrelin and PYY3-36 increased in AN patients and these changes were not normalized in contrast to insulin after treatment. The increase in both orexigenic ghrelin and anorexigenic PYY3-36 may have a role in pathological eating behavior in AN.

Authors+Show Affiliations

Department of Behavioral Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, 8-35-1, Sakuragaoka, Kagoshima City 890-8520, Japan. ayana-n@m3.kufm.kagoshima-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17054989

Citation

Nakahara, Toshihiro, et al. "Incomplete Restoration of the Secretion of Ghrelin and PYY Compared to Insulin After Food Ingestion Following Weight Gain in Anorexia Nervosa." Journal of Psychiatric Research, vol. 41, no. 10, 2007, pp. 814-20.
Nakahara T, Kojima S, Tanaka M, et al. Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa. J Psychiatr Res. 2007;41(10):814-20.
Nakahara, T., Kojima, S., Tanaka, M., Yasuhara, D., Harada, T., Sagiyama, K., ... Inui, A. (2007). Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa. Journal of Psychiatric Research, 41(10), pp. 814-20.
Nakahara T, et al. Incomplete Restoration of the Secretion of Ghrelin and PYY Compared to Insulin After Food Ingestion Following Weight Gain in Anorexia Nervosa. J Psychiatr Res. 2007;41(10):814-20. PubMed PMID: 17054989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa. AU - Nakahara,Toshihiro, AU - Kojima,Shinya, AU - Tanaka,Muneki, AU - Yasuhara,Daisuke, AU - Harada,Toshiro, AU - Sagiyama,Ken-ichiro, AU - Muranaga,Tetsuro, AU - Nagai,Nobuathu, AU - Nakazato,Masamitsu, AU - Nozoe,Shin-ichi, AU - Naruo,Tetsuro, AU - Inui,Akio, Y1 - 2006/10/19/ PY - 2006/05/14/received PY - 2006/07/27/revised PY - 2006/07/27/accepted PY - 2006/10/24/pubmed PY - 2007/8/10/medline PY - 2006/10/24/entrez SP - 814 EP - 20 JF - Journal of psychiatric research JO - J Psychiatr Res VL - 41 IS - 10 N2 - BACKGROUND: In humans, ghrelin has been found to stimulate appetite while PYY3-36 to reduce it; these orexigenic and anorexigenic peptides play significant roles in appetite control. We investigated pre- and postprandial responses of ghrelin and PYY in anorexia nervosa (AN) and the influence of weight gain. METHODS: Plasma ghrelin, PYY3-36, glucose and insulin responses after ingestion of a 400 kcal standard meal were measured in 14 patients with restricting type of AN and 12 controls. The AN patients were evaluated before therapy and after inpatient therapy. Psychometry was performed by the use of Eating Disorders Inventory. RESULTS: Ghrelin was suppressed during the meal test, while PYY3-36 was increased in all of the groups. Before therapy, AN patients had significantly increased levels of ghrelin and PYY3-36 compared to the control (P<0.01). After therapeutic intervention, as the nutritional status of AN patients improved, the secretion of these hormones were increased (P<0.05), but not normalized as in psychological testing. In contrast, insulin and glucose responses were normalized after inpatient therapy. CONCLUSIONS: We found that both ghrelin and PYY3-36 increased in AN patients and these changes were not normalized in contrast to insulin after treatment. The increase in both orexigenic ghrelin and anorexigenic PYY3-36 may have a role in pathological eating behavior in AN. SN - 0022-3956 UR - https://www.unboundmedicine.com/medline/citation/17054989/Incomplete_restoration_of_the_secretion_of_ghrelin_and_PYY_compared_to_insulin_after_food_ingestion_following_weight_gain_in_anorexia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-3956(06)00167-1 DB - PRIME DP - Unbound Medicine ER -