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Morphogenesis and cell cycle progression in Candida albicans.

Abstract

Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle progression. In particular, in hyphal cells, polarized growth becomes uncoupled from other cell cycle events. Yeast or pseudohyphae that undergo a cell cycle delay also exhibit polarized growth, independent of cell cycle progression. The Spitzenkörper, an organelle composed of vesicles associated with hyphal tips, directs continuous hyphal elongation in filamentous fungal species and also in C. albicans hyphae. A polarisome mediates cell cycle dependent growth in yeast and pseudohyphae. Regulation of morphogenesis and cell cycle progression is dependent upon specific cyclins, all of which affect morphogenesis and some of which function specifically in yeast or hyphal cells. Future work will probably focus on the cell cycle checkpoints involved in connecting morphogenesis to cell cycle progression.

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  • Authors+Show Affiliations

    Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA. jberman@umn.edu

    Source

    Current opinion in microbiology 9:6 2006 Dec pg 595-601

    MeSH

    Candida albicans
    Cell Cycle
    Cell Cycle Proteins
    Cell Polarity
    Gene Expression Regulation, Fungal
    Hyphae
    Morphogenesis
    Protein Kinases

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Review

    Language

    eng

    PubMed ID

    17055773

    Citation

    TY - JOUR T1 - Morphogenesis and cell cycle progression in Candida albicans. A1 - Berman,Judith, Y1 - 2006/10/20/ PY - 2006/7/24/received PY - 2006/10/20/aheadofprint PY - 2006/10/24/pubmed PY - 2007/3/3/medline PY - 2006/10/24/entrez SP - 595 EP - 601 JF - Current opinion in microbiology JO - Curr. Opin. Microbiol. VL - 9 IS - 6 N2 - Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle progression. In particular, in hyphal cells, polarized growth becomes uncoupled from other cell cycle events. Yeast or pseudohyphae that undergo a cell cycle delay also exhibit polarized growth, independent of cell cycle progression. The Spitzenkörper, an organelle composed of vesicles associated with hyphal tips, directs continuous hyphal elongation in filamentous fungal species and also in C. albicans hyphae. A polarisome mediates cell cycle dependent growth in yeast and pseudohyphae. Regulation of morphogenesis and cell cycle progression is dependent upon specific cyclins, all of which affect morphogenesis and some of which function specifically in yeast or hyphal cells. Future work will probably focus on the cell cycle checkpoints involved in connecting morphogenesis to cell cycle progression. SN - 1369-5274 UR - https://www.unboundmedicine.com/medline/citation/17055773/Morphogenesis_and_cell_cycle_progression_in_Candida_albicans_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S1369-5274(06)00159-7 ER -