Tags

Type your tag names separated by a space and hit enter

Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine.
Psychopharmacology (Berl). 2006 Dec; 189(2):259-66.P

Abstract

OBJECTIVE

To compare the long-term efficacy and safety of aripiprazole with olanzapine in patients with either acute relapsing or chronic, stable schizophrenia.

MATERIALS AND METHODS

A 52-week, open-label extension to a 26-week, multicenter, randomized, double-blind, placebo-controlled trial in patients with chronic schizophrenia. Patients who completed the initial treatment or who met the protocol definition of relapse after > or =2 weeks of double-blind treatment were randomized to aripiprazole (15-30 mg/day, n = 104) or olanzapine (10-20 mg/day, n = 110) for 52 weeks.

RESULTS

Sixty-nine percent of patients completed the study. Efficacy improvements were similar between groups at endpoint, mean reductions in Positive and Negative Syndrome Scale (PANSS) Total scores from baseline for patients completing the study (observed cases) were similar in chronic stable patients (aripiprazole, -7.94; olanzapine, -7.36) and in patients with acute relapse (aripiprazole, -31.19; olanzapine, -29.55). Olanzapine-treated patients reported more extrapyramidal symptoms (EPS)-related adverse events (18%) than aripiprazole-treated patients (10%). No significant differences in EPS were seen between treatments at endpoint. Olanzapine was associated with significantly greater weight gain than aripiprazole at all time points (week 52 [LOCF]: +2.54 vs +0.04 kg; p < 0.001). Changes in fasting glucose and lipid levels at endpoint favored aripiprazole over olanzapine, with significant differences observed for total cholesterol, low- and high-density lipoprotein. While differences observed for changes in fasting glucose and triglycerides favored aripiprazole, they were not statistically significant.

CONCLUSION

Aripiprazole showed similar efficacy to olanzapine for long-term treatment of acutely psychotic and chronic, stable schizophrenia patients, with a lower liability for weight gain or increased lipid levels.

Authors+Show Affiliations

Department of Psychiatry, Medical Academy in Bialystok, Plac Brodowicza 1, 16-070, Choroszcz, Poland. promedica@onet.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

17058105

Citation

Chrzanowski, Wlodzimierz K., et al. "Effectiveness of Long-term Aripiprazole Therapy in Patients With Acutely Relapsing or Chronic, Stable Schizophrenia: a 52-week, Open-label Comparison With Olanzapine." Psychopharmacology, vol. 189, no. 2, 2006, pp. 259-66.
Chrzanowski WK, Marcus RN, Torbeyns A, et al. Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine. Psychopharmacology (Berl). 2006;189(2):259-66.
Chrzanowski, W. K., Marcus, R. N., Torbeyns, A., Nyilas, M., & McQuade, R. D. (2006). Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine. Psychopharmacology, 189(2), 259-66.
Chrzanowski WK, et al. Effectiveness of Long-term Aripiprazole Therapy in Patients With Acutely Relapsing or Chronic, Stable Schizophrenia: a 52-week, Open-label Comparison With Olanzapine. Psychopharmacology (Berl). 2006;189(2):259-66. PubMed PMID: 17058105.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of long-term aripiprazole therapy in patients with acutely relapsing or chronic, stable schizophrenia: a 52-week, open-label comparison with olanzapine. AU - Chrzanowski,Wlodzimierz K, AU - Marcus,Ronald N, AU - Torbeyns,Anne, AU - Nyilas,Margaretta, AU - McQuade,Robert D, Y1 - 2006/10/21/ PY - 2006/01/24/received PY - 2006/08/14/accepted PY - 2006/10/24/pubmed PY - 2007/2/6/medline PY - 2006/10/24/entrez SP - 259 EP - 66 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 189 IS - 2 N2 - OBJECTIVE: To compare the long-term efficacy and safety of aripiprazole with olanzapine in patients with either acute relapsing or chronic, stable schizophrenia. MATERIALS AND METHODS: A 52-week, open-label extension to a 26-week, multicenter, randomized, double-blind, placebo-controlled trial in patients with chronic schizophrenia. Patients who completed the initial treatment or who met the protocol definition of relapse after > or =2 weeks of double-blind treatment were randomized to aripiprazole (15-30 mg/day, n = 104) or olanzapine (10-20 mg/day, n = 110) for 52 weeks. RESULTS: Sixty-nine percent of patients completed the study. Efficacy improvements were similar between groups at endpoint, mean reductions in Positive and Negative Syndrome Scale (PANSS) Total scores from baseline for patients completing the study (observed cases) were similar in chronic stable patients (aripiprazole, -7.94; olanzapine, -7.36) and in patients with acute relapse (aripiprazole, -31.19; olanzapine, -29.55). Olanzapine-treated patients reported more extrapyramidal symptoms (EPS)-related adverse events (18%) than aripiprazole-treated patients (10%). No significant differences in EPS were seen between treatments at endpoint. Olanzapine was associated with significantly greater weight gain than aripiprazole at all time points (week 52 [LOCF]: +2.54 vs +0.04 kg; p < 0.001). Changes in fasting glucose and lipid levels at endpoint favored aripiprazole over olanzapine, with significant differences observed for total cholesterol, low- and high-density lipoprotein. While differences observed for changes in fasting glucose and triglycerides favored aripiprazole, they were not statistically significant. CONCLUSION: Aripiprazole showed similar efficacy to olanzapine for long-term treatment of acutely psychotic and chronic, stable schizophrenia patients, with a lower liability for weight gain or increased lipid levels. SN - 0033-3158 UR - https://www.unboundmedicine.com/medline/citation/17058105/Effectiveness_of_long_term_aripiprazole_therapy_in_patients_with_acutely_relapsing_or_chronic_stable_schizophrenia:_a_52_week_open_label_comparison_with_olanzapine_ L2 - https://dx.doi.org/10.1007/s00213-006-0564-3 DB - PRIME DP - Unbound Medicine ER -