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Surveillance of neural tube defects in Israel: the effect of the recommendation for periconceptional folic acid.
Isr Med Assoc J. 2006 Sep; 8(9):601-4.IM

Abstract

BACKGROUND

Open neural tube defects are among the most common severely disabling birth defects. Secondary prevention by early diagnosis during pregnancy and abortion of affected fetuses lead to a marked reduction of NTD incidence at birth. For primary prevention of these defects, in August 2000 the Israel Ministry of Health issued guidelines recommending a daily 0.4 mg folic acid supplement for all women in their childbearing years with special emphasis on the 3 months preceding conception and the first trimester of pregnancy.

OBJECTIVES

To compare the epidemiologic characteristics of NTD in Israel before and after the guidelines for folic acid supplementation.

METHODS

A national registry of NTD was begun in 1999. Since the Ministry of Health published the recommendation for folic acid supplementation in mid-2000, the years 1999-2000 represent the status prior to the recommendation and the years 2002-2004 the status after.

RESULTS

A marked decline in the rate of spina bifida was observed in the last 3 years (from 4.9 to 2.7 per 10,000 live births among Jews and 9.5 to 6.2 among Arabs and Druze). There was no apparent reduction for anencephaly.

CONCLUSIONS

Following the Ministry of Health guidelines on folic acid supplementation for women in the reproductive age, a marked reduction in the rates of NTD was observed. In light of this apparent success, continuous efforts should be made to increase the percentage of women taking the supplementation and, especially, to introduce folic acid fortification.

Authors+Show Affiliations

Dept of Community Genetics, Sheba Medical Center, Public Health Services, Ministry of Health, Tel Hashomer, Israel. joel.zlotogora@moh.health.gov.ilNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17058407

Citation

Zlotogora, Joël, et al. "Surveillance of Neural Tube Defects in Israel: the Effect of the Recommendation for Periconceptional Folic Acid." The Israel Medical Association Journal : IMAJ, vol. 8, no. 9, 2006, pp. 601-4.
Zlotogora J, Amitai Y, Leventhal A. Surveillance of neural tube defects in Israel: the effect of the recommendation for periconceptional folic acid. Isr Med Assoc J. 2006;8(9):601-4.
Zlotogora, J., Amitai, Y., & Leventhal, A. (2006). Surveillance of neural tube defects in Israel: the effect of the recommendation for periconceptional folic acid. The Israel Medical Association Journal : IMAJ, 8(9), 601-4.
Zlotogora J, Amitai Y, Leventhal A. Surveillance of Neural Tube Defects in Israel: the Effect of the Recommendation for Periconceptional Folic Acid. Isr Med Assoc J. 2006;8(9):601-4. PubMed PMID: 17058407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surveillance of neural tube defects in Israel: the effect of the recommendation for periconceptional folic acid. AU - Zlotogora,Joël, AU - Amitai,Yona, AU - Leventhal,Alex, PY - 2006/10/25/pubmed PY - 2006/11/11/medline PY - 2006/10/25/entrez SP - 601 EP - 4 JF - The Israel Medical Association journal : IMAJ JO - Isr Med Assoc J VL - 8 IS - 9 N2 - BACKGROUND: Open neural tube defects are among the most common severely disabling birth defects. Secondary prevention by early diagnosis during pregnancy and abortion of affected fetuses lead to a marked reduction of NTD incidence at birth. For primary prevention of these defects, in August 2000 the Israel Ministry of Health issued guidelines recommending a daily 0.4 mg folic acid supplement for all women in their childbearing years with special emphasis on the 3 months preceding conception and the first trimester of pregnancy. OBJECTIVES: To compare the epidemiologic characteristics of NTD in Israel before and after the guidelines for folic acid supplementation. METHODS: A national registry of NTD was begun in 1999. Since the Ministry of Health published the recommendation for folic acid supplementation in mid-2000, the years 1999-2000 represent the status prior to the recommendation and the years 2002-2004 the status after. RESULTS: A marked decline in the rate of spina bifida was observed in the last 3 years (from 4.9 to 2.7 per 10,000 live births among Jews and 9.5 to 6.2 among Arabs and Druze). There was no apparent reduction for anencephaly. CONCLUSIONS: Following the Ministry of Health guidelines on folic acid supplementation for women in the reproductive age, a marked reduction in the rates of NTD was observed. In light of this apparent success, continuous efforts should be made to increase the percentage of women taking the supplementation and, especially, to introduce folic acid fortification. SN - 1565-1088 UR - https://www.unboundmedicine.com/medline/citation/17058407/Surveillance_of_neural_tube_defects_in_Israel:_the_effect_of_the_recommendation_for_periconceptional_folic_acid_ DB - PRIME DP - Unbound Medicine ER -