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[From the Cochrane Library: topical antibiotic treatment is more effective than systemic antibiotic treatment for chronic otitis media with eardrum perforation and purulent discharge].
Ned Tijdschr Geneeskd. 2006 Sep 16; 150(37):2033-5.NT

Abstract

Chronic suppurative otitis media with underlying persistent eardrum perforation is a common cause of preventable hearing impairment. A Cochrane systematic review compared topical treatment (antibiotics or antiseptics) with systemic antibiotics to identify which is best. Nine randomised controlled trials were included (833 randomised patients; 842 analysed patients or ears). Topical treatment with quinolones was more effective in stopping (purulent) discharge than systemic treatment with quinolones or non-quinolones. No benefit from adding systemic treatment to topical antibiotics was detected. The effects of topical non-quinolone antibiotics or antiseptics were not clear. Little is known about secondary outcomes (prevention of complications, healing the eardrum, and improving hearing) or about the efficacy and safety of topical antibiotics in the long term.

Authors+Show Affiliations

Hamerlynck JV
Academisch Medisch Centrum/Universiteit van Amsterdam, Dutch Cochrane Centre. j.v.hamerlynck@amc.uva.nl
van Benthem PP
No affiliation info available
Scholten RJ
No affiliation info available

MeSH

Administration, TopicalAnti-Bacterial AgentsHumansOtitis Media, SuppurativeTreatment Outcome

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

dut

PubMed ID

17058460

Citation

Hamerlynck, J V Th H., et al. "[From the Cochrane Library: Topical Antibiotic Treatment Is More Effective Than Systemic Antibiotic Treatment for Chronic Otitis Media With Eardrum Perforation and Purulent Discharge]." Nederlands Tijdschrift Voor Geneeskunde, vol. 150, no. 37, 2006, pp. 2033-5.
Hamerlynck JV, van Benthem PP, Scholten RJ. [From the Cochrane Library: topical antibiotic treatment is more effective than systemic antibiotic treatment for chronic otitis media with eardrum perforation and purulent discharge]. Ned Tijdschr Geneeskd. 2006;150(37):2033-5.
Hamerlynck, J. V., van Benthem, P. P., & Scholten, R. J. (2006). [From the Cochrane Library: topical antibiotic treatment is more effective than systemic antibiotic treatment for chronic otitis media with eardrum perforation and purulent discharge]. Nederlands Tijdschrift Voor Geneeskunde, 150(37), 2033-5.
Hamerlynck JV, van Benthem PP, Scholten RJ. [From the Cochrane Library: Topical Antibiotic Treatment Is More Effective Than Systemic Antibiotic Treatment for Chronic Otitis Media With Eardrum Perforation and Purulent Discharge]. Ned Tijdschr Geneeskd. 2006 Sep 16;150(37):2033-5. PubMed PMID: 17058460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [From the Cochrane Library: topical antibiotic treatment is more effective than systemic antibiotic treatment for chronic otitis media with eardrum perforation and purulent discharge]. AU - Hamerlynck,J V Th H, AU - van Benthem,P P G, AU - Scholten,R J P M, PY - 2006/10/25/pubmed PY - 2006/11/11/medline PY - 2006/10/25/entrez SP - 2033 EP - 5 JF - Nederlands tijdschrift voor geneeskunde JO - Ned Tijdschr Geneeskd VL - 150 IS - 37 N2 - Chronic suppurative otitis media with underlying persistent eardrum perforation is a common cause of preventable hearing impairment. A Cochrane systematic review compared topical treatment (antibiotics or antiseptics) with systemic antibiotics to identify which is best. Nine randomised controlled trials were included (833 randomised patients; 842 analysed patients or ears). Topical treatment with quinolones was more effective in stopping (purulent) discharge than systemic treatment with quinolones or non-quinolones. No benefit from adding systemic treatment to topical antibiotics was detected. The effects of topical non-quinolone antibiotics or antiseptics were not clear. Little is known about secondary outcomes (prevention of complications, healing the eardrum, and improving hearing) or about the efficacy and safety of topical antibiotics in the long term. SN - 0028-2162 UR - https://www.unboundmedicine.com/medline/citation/17058460/[From_the_Cochrane_Library:_topical_antibiotic_treatment_is_more_effective_than_systemic_antibiotic_treatment_for_chronic_otitis_media_with_eardrum_perforation_and_purulent_discharge]_ DB - PRIME DP - Unbound Medicine ER -