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Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis.

Abstract

The role of trace elements in the pathogenesis of liver cirrhosis and its complications is still not clearly understood. Serum concentrations of zinc, copper, manganese and magnesium were determined in 105 patients with alcoholic liver cirrhosis and 50 healthy subjects by means of plasma sequential spectrophotometer. Serum concentrations of zinc were significantly lower (median 0.82 vs. 11.22 micromol/L, p < 0.001) in patients with liver cirrhosis in comparison to controls. Serum concentrations of copper were significantly higher in patients with liver cirrhosis (median 21.56 vs. 13.09 micromol/L, p < 0.001) as well as manganese (2.50 vs. 0.02 micromol/L, p < 0.001). The concentration of magnesium was not significantly different between patients with liver cirrhosis and controls (0.94 vs. 0.88 mmol/L, p = 0.132). There were no differences in the concentrations of zinc, copper, manganese and magnesium between male and female patients with liver cirrhosis. Only manganese concentration was significantly different between Child-Pugh groups (p = 0.036). Zinc concentration was significantly lower in patients with hepatic encephalopathy in comparison to cirrhotic patients without encephalopathy (0.54 vs. 0.96 micromol/L, p = 0.002). The correction of trace elements concentrations might have a beneficial effect on complications and maybe progression of liver cirrhosis. It would be recommendable to provide analysis of trace elements as a routine.

Authors+Show Affiliations

,

Division of Gastroenterology, Dubrava University Hospital, Zagreb, Croatia. drahelic@kbd.hr

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Source

Collegium antropologicum 30:3 2006 Sep pg 523-8

MeSH

Ascites
Case-Control Studies
Copper
Female
Humans
Liver Cirrhosis, Alcoholic
Magnesium
Male
Manganese
Middle Aged
Trace Elements
Zinc

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17058518

Citation

Rahelić, Dario, et al. "Serum Concentration of Zinc, Copper, Manganese and Magnesium in Patients With Liver Cirrhosis." Collegium Antropologicum, vol. 30, no. 3, 2006, pp. 523-8.
Rahelić D, Kujundzić M, Romić Z, et al. Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Coll Antropol. 2006;30(3):523-8.
Rahelić, D., Kujundzić, M., Romić, Z., Brkić, K., & Petrovecki, M. (2006). Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. Collegium Antropologicum, 30(3), pp. 523-8.
Rahelić D, et al. Serum Concentration of Zinc, Copper, Manganese and Magnesium in Patients With Liver Cirrhosis. Coll Antropol. 2006;30(3):523-8. PubMed PMID: 17058518.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum concentration of zinc, copper, manganese and magnesium in patients with liver cirrhosis. AU - Rahelić,Dario, AU - Kujundzić,Milan, AU - Romić,Zeljko, AU - Brkić,Kristina, AU - Petrovecki,Mladen, PY - 2006/10/25/pubmed PY - 2006/11/3/medline PY - 2006/10/25/entrez SP - 523 EP - 8 JF - Collegium antropologicum JO - Coll Antropol VL - 30 IS - 3 N2 - The role of trace elements in the pathogenesis of liver cirrhosis and its complications is still not clearly understood. Serum concentrations of zinc, copper, manganese and magnesium were determined in 105 patients with alcoholic liver cirrhosis and 50 healthy subjects by means of plasma sequential spectrophotometer. Serum concentrations of zinc were significantly lower (median 0.82 vs. 11.22 micromol/L, p < 0.001) in patients with liver cirrhosis in comparison to controls. Serum concentrations of copper were significantly higher in patients with liver cirrhosis (median 21.56 vs. 13.09 micromol/L, p < 0.001) as well as manganese (2.50 vs. 0.02 micromol/L, p < 0.001). The concentration of magnesium was not significantly different between patients with liver cirrhosis and controls (0.94 vs. 0.88 mmol/L, p = 0.132). There were no differences in the concentrations of zinc, copper, manganese and magnesium between male and female patients with liver cirrhosis. Only manganese concentration was significantly different between Child-Pugh groups (p = 0.036). Zinc concentration was significantly lower in patients with hepatic encephalopathy in comparison to cirrhotic patients without encephalopathy (0.54 vs. 0.96 micromol/L, p = 0.002). The correction of trace elements concentrations might have a beneficial effect on complications and maybe progression of liver cirrhosis. It would be recommendable to provide analysis of trace elements as a routine. SN - 0350-6134 UR - https://www.unboundmedicine.com/medline/citation/17058518/Serum_concentration_of_zinc_copper_manganese_and_magnesium_in_patients_with_liver_cirrhosis_ DB - PRIME DP - Unbound Medicine ER -