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Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis.

Abstract

OBJECTIVES

Circulating levels of matrix metalloproteinase (MMP)-10 are related to inflammation in asymptomatic subjects with cardiovascular risk factors. Whether MMP-10 is associated with the severity of atherosclerosis remains to be determined. This study examines the relationship of systemic MMP-10 levels with atherosclerotic risk factors and subclinical atherosclerosis.

METHODS AND RESULTS

Circulating levels of MMP-1, -9 and -10, and markers of inflammation [fibrinogen, interleukin-6, von Willebrand factor, and high-sensitivity C-reactive protein (hs-CRP)] were measured in 400 subjects (mean age 54.3 years, 77.7% men) with cardiovascular risk factors but free from clinical cardiovascular disease. Subclinical atherosclerosis was evaluated by both the mean carotid intima-media thickness (IMT) and the presence of atherosclerotic plaques with the use of B-mode ultrasound in all subjects. MMP-10 levels were positively correlated with fibrinogen (r = 0.24, P < 0.001), hs-CRP (r = 0.14, P < 0.01) and carotid IMT (r = 0.17, P < 0.01). The association between MMP-10 and IMT remained significant in multiple regression analysis (P < 0.02) when controlling for traditional atherosclerotic risk factors and inflammatory markers. Such an association was not observed for MMP-1 and -9. Subjects in the highest MMP-10 tertile had significantly higher carotid IMT (adjusted odds ratio 6.3, 95% confidence interval 1.3-31.4, P = 0.024). In addition, MMP-10 levels were significantly higher in patients with carotid plaques (n = 78) than in those with no plaques after adjusting for age and sex (P < 0.01).

CONCLUSION

Higher serum MMP-10 levels were associated with inflammatory markers, increased carotid IMT and atherosclerotic plaques in asymptomatic subjects. Circulating MMP-10 may be useful to identify subclinical atherosclerosis in subjects free from cardiovascular disease.

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  • Authors+Show Affiliations

    ,

    Laboratory of Atherosclerosis, Division of Cardiovascular Sciences, Center for Applied Medical Research, Pamplona, Spain.

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    Source

    MeSH

    C-Reactive Protein
    Cardiovascular Diseases
    Carotid Artery Diseases
    Carotid Artery, Common
    Female
    Fibrinogen
    Humans
    Interleukin-6
    Linear Models
    Logistic Models
    Male
    Matrix Metalloproteinase 1
    Matrix Metalloproteinase 10
    Matrix Metalloproteinase 9
    Middle Aged
    Odds Ratio
    Risk Factors
    Severity of Illness Index
    Tunica Intima
    Tunica Media
    Ultrasonography
    von Willebrand Factor

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17059420

    Citation

    Orbe, J, et al. "Independent Association of Matrix Metalloproteinase-10, Cardiovascular Risk Factors and Subclinical Atherosclerosis." Journal of Thrombosis and Haemostasis : JTH, vol. 5, no. 1, 2007, pp. 91-7.
    Orbe J, Montero I, Rodríguez JA, et al. Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. J Thromb Haemost. 2007;5(1):91-7.
    Orbe, J., Montero, I., Rodríguez, J. A., Beloqui, O., Roncal, C., & Páramo, J. A. (2007). Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. Journal of Thrombosis and Haemostasis : JTH, 5(1), pp. 91-7.
    Orbe J, et al. Independent Association of Matrix Metalloproteinase-10, Cardiovascular Risk Factors and Subclinical Atherosclerosis. J Thromb Haemost. 2007;5(1):91-7. PubMed PMID: 17059420.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. AU - Orbe,J, AU - Montero,I, AU - Rodríguez,J A, AU - Beloqui,O, AU - Roncal,C, AU - Páramo,J A, Y1 - 2006/10/16/ PY - 2006/10/25/pubmed PY - 2007/2/16/medline PY - 2006/10/25/entrez SP - 91 EP - 7 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 5 IS - 1 N2 - OBJECTIVES: Circulating levels of matrix metalloproteinase (MMP)-10 are related to inflammation in asymptomatic subjects with cardiovascular risk factors. Whether MMP-10 is associated with the severity of atherosclerosis remains to be determined. This study examines the relationship of systemic MMP-10 levels with atherosclerotic risk factors and subclinical atherosclerosis. METHODS AND RESULTS: Circulating levels of MMP-1, -9 and -10, and markers of inflammation [fibrinogen, interleukin-6, von Willebrand factor, and high-sensitivity C-reactive protein (hs-CRP)] were measured in 400 subjects (mean age 54.3 years, 77.7% men) with cardiovascular risk factors but free from clinical cardiovascular disease. Subclinical atherosclerosis was evaluated by both the mean carotid intima-media thickness (IMT) and the presence of atherosclerotic plaques with the use of B-mode ultrasound in all subjects. MMP-10 levels were positively correlated with fibrinogen (r = 0.24, P < 0.001), hs-CRP (r = 0.14, P < 0.01) and carotid IMT (r = 0.17, P < 0.01). The association between MMP-10 and IMT remained significant in multiple regression analysis (P < 0.02) when controlling for traditional atherosclerotic risk factors and inflammatory markers. Such an association was not observed for MMP-1 and -9. Subjects in the highest MMP-10 tertile had significantly higher carotid IMT (adjusted odds ratio 6.3, 95% confidence interval 1.3-31.4, P = 0.024). In addition, MMP-10 levels were significantly higher in patients with carotid plaques (n = 78) than in those with no plaques after adjusting for age and sex (P < 0.01). CONCLUSION: Higher serum MMP-10 levels were associated with inflammatory markers, increased carotid IMT and atherosclerotic plaques in asymptomatic subjects. Circulating MMP-10 may be useful to identify subclinical atherosclerosis in subjects free from cardiovascular disease. SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/17059420/Independent_association_of_matrix_metalloproteinase_10_cardiovascular_risk_factors_and_subclinical_atherosclerosis_ L2 - https://doi.org/10.1111/j.1538-7836.2006.02276.x DB - PRIME DP - Unbound Medicine ER -