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Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis.
J Thromb Haemost 2007; 5(1):91-7JT

Abstract

OBJECTIVES

Circulating levels of matrix metalloproteinase (MMP)-10 are related to inflammation in asymptomatic subjects with cardiovascular risk factors. Whether MMP-10 is associated with the severity of atherosclerosis remains to be determined. This study examines the relationship of systemic MMP-10 levels with atherosclerotic risk factors and subclinical atherosclerosis.

METHODS AND RESULTS

Circulating levels of MMP-1, -9 and -10, and markers of inflammation [fibrinogen, interleukin-6, von Willebrand factor, and high-sensitivity C-reactive protein (hs-CRP)] were measured in 400 subjects (mean age 54.3 years, 77.7% men) with cardiovascular risk factors but free from clinical cardiovascular disease. Subclinical atherosclerosis was evaluated by both the mean carotid intima-media thickness (IMT) and the presence of atherosclerotic plaques with the use of B-mode ultrasound in all subjects. MMP-10 levels were positively correlated with fibrinogen (r = 0.24, P < 0.001), hs-CRP (r = 0.14, P < 0.01) and carotid IMT (r = 0.17, P < 0.01). The association between MMP-10 and IMT remained significant in multiple regression analysis (P < 0.02) when controlling for traditional atherosclerotic risk factors and inflammatory markers. Such an association was not observed for MMP-1 and -9. Subjects in the highest MMP-10 tertile had significantly higher carotid IMT (adjusted odds ratio 6.3, 95% confidence interval 1.3-31.4, P = 0.024). In addition, MMP-10 levels were significantly higher in patients with carotid plaques (n = 78) than in those with no plaques after adjusting for age and sex (P < 0.01).

CONCLUSION

Higher serum MMP-10 levels were associated with inflammatory markers, increased carotid IMT and atherosclerotic plaques in asymptomatic subjects. Circulating MMP-10 may be useful to identify subclinical atherosclerosis in subjects free from cardiovascular disease.

Authors+Show Affiliations

Laboratory of Atherosclerosis, Division of Cardiovascular Sciences, Center for Applied Medical Research, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17059420

Citation

Orbe, J, et al. "Independent Association of Matrix Metalloproteinase-10, Cardiovascular Risk Factors and Subclinical Atherosclerosis." Journal of Thrombosis and Haemostasis : JTH, vol. 5, no. 1, 2007, pp. 91-7.
Orbe J, Montero I, Rodríguez JA, et al. Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. J Thromb Haemost. 2007;5(1):91-7.
Orbe, J., Montero, I., Rodríguez, J. A., Beloqui, O., Roncal, C., & Páramo, J. A. (2007). Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. Journal of Thrombosis and Haemostasis : JTH, 5(1), pp. 91-7.
Orbe J, et al. Independent Association of Matrix Metalloproteinase-10, Cardiovascular Risk Factors and Subclinical Atherosclerosis. J Thromb Haemost. 2007;5(1):91-7. PubMed PMID: 17059420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent association of matrix metalloproteinase-10, cardiovascular risk factors and subclinical atherosclerosis. AU - Orbe,J, AU - Montero,I, AU - Rodríguez,J A, AU - Beloqui,O, AU - Roncal,C, AU - Páramo,J A, Y1 - 2006/10/16/ PY - 2006/10/25/pubmed PY - 2007/2/16/medline PY - 2006/10/25/entrez SP - 91 EP - 7 JF - Journal of thrombosis and haemostasis : JTH JO - J. Thromb. Haemost. VL - 5 IS - 1 N2 - OBJECTIVES: Circulating levels of matrix metalloproteinase (MMP)-10 are related to inflammation in asymptomatic subjects with cardiovascular risk factors. Whether MMP-10 is associated with the severity of atherosclerosis remains to be determined. This study examines the relationship of systemic MMP-10 levels with atherosclerotic risk factors and subclinical atherosclerosis. METHODS AND RESULTS: Circulating levels of MMP-1, -9 and -10, and markers of inflammation [fibrinogen, interleukin-6, von Willebrand factor, and high-sensitivity C-reactive protein (hs-CRP)] were measured in 400 subjects (mean age 54.3 years, 77.7% men) with cardiovascular risk factors but free from clinical cardiovascular disease. Subclinical atherosclerosis was evaluated by both the mean carotid intima-media thickness (IMT) and the presence of atherosclerotic plaques with the use of B-mode ultrasound in all subjects. MMP-10 levels were positively correlated with fibrinogen (r = 0.24, P < 0.001), hs-CRP (r = 0.14, P < 0.01) and carotid IMT (r = 0.17, P < 0.01). The association between MMP-10 and IMT remained significant in multiple regression analysis (P < 0.02) when controlling for traditional atherosclerotic risk factors and inflammatory markers. Such an association was not observed for MMP-1 and -9. Subjects in the highest MMP-10 tertile had significantly higher carotid IMT (adjusted odds ratio 6.3, 95% confidence interval 1.3-31.4, P = 0.024). In addition, MMP-10 levels were significantly higher in patients with carotid plaques (n = 78) than in those with no plaques after adjusting for age and sex (P < 0.01). CONCLUSION: Higher serum MMP-10 levels were associated with inflammatory markers, increased carotid IMT and atherosclerotic plaques in asymptomatic subjects. Circulating MMP-10 may be useful to identify subclinical atherosclerosis in subjects free from cardiovascular disease. SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/17059420/Independent_association_of_matrix_metalloproteinase_10_cardiovascular_risk_factors_and_subclinical_atherosclerosis_ L2 - https://doi.org/10.1111/j.1538-7836.2006.02276.x DB - PRIME DP - Unbound Medicine ER -