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The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to women.
Obes Surg. 2006 Oct; 16(10):1351-8.OS

Abstract

BACKGROUND

Nonalcoholic steatohepatitis (NASH) is a form of liver injury that is common in morbidly obese subjects. It has been shown that gender differences exist in the spectrum of nonalcoholic fatty liver disease (NAFLD). The focus of this study was to further characterize these gender differences based on ATP III criteria used to diagnose the metabolic syndrome (MS).

METHODS

We retrospectively assessed NAFLD 58 men and 307 women who underwent gastric bypass, for the presence of NASH, MS, and positive predictors of NASH.

RESULTS

There was no statistical difference in age, gender, or the presence of diabetes. The prevalence of NASH in men and women was 60.3% and 30.9%, respectively (P<0.001). Multivariate logistic analysis showed an association of male gender with NASH (2.7; 95% CI, 1.3-5.6, P=0.006) as well as age, AST, and diabetes. MS was diagnosed in 91.4% and 76.2% of men and women (P=0.008), and men tended to have more criteria for MS compared to women. The only positive predictor of MS that was statistically significant between genders was high triglycerides (P=0.003). Controlling for BMI and excess body weight produced similar results.

CONCLUSIONS

Gender differences do exist within NAFLD and MS, that may be associated with free fatty acid flow to the liver.

Authors+Show Affiliations

Division of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, AL 35294, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17059746

Citation

Arun, Janani, et al. "The Prevalence of Nonalcoholic Steatohepatitis Is Greater in Morbidly Obese Men Compared to Women." Obesity Surgery, vol. 16, no. 10, 2006, pp. 1351-8.
Arun J, Clements RH, Lazenby AJ, et al. The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to women. Obes Surg. 2006;16(10):1351-8.
Arun, J., Clements, R. H., Lazenby, A. J., Leeth, R. R., & Abrams, G. A. (2006). The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to women. Obesity Surgery, 16(10), 1351-8.
Arun J, et al. The Prevalence of Nonalcoholic Steatohepatitis Is Greater in Morbidly Obese Men Compared to Women. Obes Surg. 2006;16(10):1351-8. PubMed PMID: 17059746.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of nonalcoholic steatohepatitis is greater in morbidly obese men compared to women. AU - Arun,Janani, AU - Clements,Ronald H, AU - Lazenby,Audrey J, AU - Leeth,Ruth R, AU - Abrams,Gary A, PY - 2006/10/25/pubmed PY - 2007/1/11/medline PY - 2006/10/25/entrez SP - 1351 EP - 8 JF - Obesity surgery JO - Obes Surg VL - 16 IS - 10 N2 - BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a form of liver injury that is common in morbidly obese subjects. It has been shown that gender differences exist in the spectrum of nonalcoholic fatty liver disease (NAFLD). The focus of this study was to further characterize these gender differences based on ATP III criteria used to diagnose the metabolic syndrome (MS). METHODS: We retrospectively assessed NAFLD 58 men and 307 women who underwent gastric bypass, for the presence of NASH, MS, and positive predictors of NASH. RESULTS: There was no statistical difference in age, gender, or the presence of diabetes. The prevalence of NASH in men and women was 60.3% and 30.9%, respectively (P<0.001). Multivariate logistic analysis showed an association of male gender with NASH (2.7; 95% CI, 1.3-5.6, P=0.006) as well as age, AST, and diabetes. MS was diagnosed in 91.4% and 76.2% of men and women (P=0.008), and men tended to have more criteria for MS compared to women. The only positive predictor of MS that was statistically significant between genders was high triglycerides (P=0.003). Controlling for BMI and excess body weight produced similar results. CONCLUSIONS: Gender differences do exist within NAFLD and MS, that may be associated with free fatty acid flow to the liver. SN - 0960-8923 UR - https://www.unboundmedicine.com/medline/citation/17059746/The_prevalence_of_nonalcoholic_steatohepatitis_is_greater_in_morbidly_obese_men_compared_to_women_ L2 - https://dx.doi.org/10.1381/096089206778663715 DB - PRIME DP - Unbound Medicine ER -