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[Analysis of serum T-lymphocyte subsets and NK cell activity in patients with hypopharyngeal squamous cell carcinoma].
Ai Zheng. 2006 Oct; 25(10):1300-2.AZ

Abstract

BACKGROUND & OBJECTIVE

T-lymphocyte subsets and NK cell are the major forms of cellular immunity. Study of these 2 types of cells may lead to the better understanding of the function of cellular immunity in the onset and development of carcinoma. To a certain degree, there may be cellular immunodeficiency existing in patients with hypopharyngeal squamous cell carcinoma. This study was to investigate the cellular immunity function in these patients.

METHODS

T-lymphocyte subsets and NK activity were determined by flow cytometry in 78 patients with hypopharyngeal squamous cell carcinoma. Blood samples of 20 non-tumor patients were used as control.

RESULTS

The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in carcinoma group than in control group, but CD8 lymphocyte level was higher in carcinoma group. The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in T3-4 group than in T1-2 group, and lower in N+ group than in N0 group. The levels of CD4 lymphocyte subsets and CD4/CD8 ratio were decreased in the carcinoma with moderate or low differentiation (P<0.05).

CONCLUSIONS

T-lymphocyte subsets and NK activity are inhibited, and the cellular immunology is suppressed in the patients with hypopharyngeal squamous cell carcinoma. Analyzing T-lymphocyte subsets and NK activity would be helpful to evaluate the cellular immunologic condition of these patients.

Authors+Show Affiliations

State Key Laboratory of Oncology in South China, Guangzhou, Guangdong, 510060, P. R. China. chenwenkuan@163.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17059781

Citation

Chen, Wen-Kuan, et al. "[Analysis of Serum T-lymphocyte Subsets and NK Cell Activity in Patients With Hypopharyngeal Squamous Cell Carcinoma]." Ai Zheng = Aizheng = Chinese Journal of Cancer, vol. 25, no. 10, 2006, pp. 1300-2.
Chen WK, Song M, Chen FJ, et al. [Analysis of serum T-lymphocyte subsets and NK cell activity in patients with hypopharyngeal squamous cell carcinoma]. Ai Zheng. 2006;25(10):1300-2.
Chen, W. K., Song, M., Chen, F. J., Guo, Z. M., He, L. R., & Yan, S. L. (2006). [Analysis of serum T-lymphocyte subsets and NK cell activity in patients with hypopharyngeal squamous cell carcinoma]. Ai Zheng = Aizheng = Chinese Journal of Cancer, 25(10), 1300-2.
Chen WK, et al. [Analysis of Serum T-lymphocyte Subsets and NK Cell Activity in Patients With Hypopharyngeal Squamous Cell Carcinoma]. Ai Zheng. 2006;25(10):1300-2. PubMed PMID: 17059781.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Analysis of serum T-lymphocyte subsets and NK cell activity in patients with hypopharyngeal squamous cell carcinoma]. AU - Chen,Wen-Kuan, AU - Song,Ming, AU - Chen,Fu-Jin, AU - Guo,Zhu-Ming, AU - He,Li-Rong, AU - Yan,Su-Li, PY - 2006/10/25/pubmed PY - 2008/1/3/medline PY - 2006/10/25/entrez SP - 1300 EP - 2 JF - Ai zheng = Aizheng = Chinese journal of cancer JO - Ai Zheng VL - 25 IS - 10 N2 - BACKGROUND & OBJECTIVE: T-lymphocyte subsets and NK cell are the major forms of cellular immunity. Study of these 2 types of cells may lead to the better understanding of the function of cellular immunity in the onset and development of carcinoma. To a certain degree, there may be cellular immunodeficiency existing in patients with hypopharyngeal squamous cell carcinoma. This study was to investigate the cellular immunity function in these patients. METHODS: T-lymphocyte subsets and NK activity were determined by flow cytometry in 78 patients with hypopharyngeal squamous cell carcinoma. Blood samples of 20 non-tumor patients were used as control. RESULTS: The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in carcinoma group than in control group, but CD8 lymphocyte level was higher in carcinoma group. The levels of CD4 lymphocyte subsets, CD4/CD8 ratio, and NK activity were lower in T3-4 group than in T1-2 group, and lower in N+ group than in N0 group. The levels of CD4 lymphocyte subsets and CD4/CD8 ratio were decreased in the carcinoma with moderate or low differentiation (P<0.05). CONCLUSIONS: T-lymphocyte subsets and NK activity are inhibited, and the cellular immunology is suppressed in the patients with hypopharyngeal squamous cell carcinoma. Analyzing T-lymphocyte subsets and NK activity would be helpful to evaluate the cellular immunologic condition of these patients. UR - https://www.unboundmedicine.com/medline/citation/17059781/[Analysis_of_serum_T_lymphocyte_subsets_and_NK_cell_activity_in_patients_with_hypopharyngeal_squamous_cell_carcinoma]_ L2 - http://www.diseaseinfosearch.org/result/1077 DB - PRIME DP - Unbound Medicine ER -