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Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice.
Matrix Biol. 2007 Jan; 26(1):54-7.MB

Abstract

Brain microvascular endothelial cells (ECs) have unique characteristics distinguished from peripheral ECs and play important roles in blood-brain barrier (BBB). To investigate the physiological control of the brain ECs, we generated a transgenic mouse line in which the expression of Cre recombinase was driven by the promoter of the mouse surfactant protein A (SP-A) gene. The Cre activity was detected in blood vessels of brain, alveolar type II cells of lung and epithelium of gland stomach. In brain ECs, the Cre activity started at embryonic day 11.5, indicating that the subpopulation of ECs in brain could be molecularly defined at early embryonic stages. The use of SP-A-Cre mice should facilitate analysis of gene function in the brain ECs.

Authors+Show Affiliations

Genetic Laboratory of Development and Diseases, Institute of Biotechnology, Beijing, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17059883

Citation

Meng, Fanwei, et al. "Surfactant Protein a Promoter Directs the Expression of Cre Recombinase in Brain Microvascular Endothelial Cells of Transgenic Mice." Matrix Biology : Journal of the International Society for Matrix Biology, vol. 26, no. 1, 2007, pp. 54-7.
Meng F, Shi L, Cheng X, et al. Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. Matrix Biol. 2007;26(1):54-7.
Meng, F., Shi, L., Cheng, X., Hou, N., Wang, Y., Teng, Y., Meng, A., & Yang, X. (2007). Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. Matrix Biology : Journal of the International Society for Matrix Biology, 26(1), 54-7.
Meng F, et al. Surfactant Protein a Promoter Directs the Expression of Cre Recombinase in Brain Microvascular Endothelial Cells of Transgenic Mice. Matrix Biol. 2007;26(1):54-7. PubMed PMID: 17059883.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice. AU - Meng,Fanwei, AU - Shi,Ling, AU - Cheng,Xuan, AU - Hou,Ning, AU - Wang,Yongliang, AU - Teng,Yan, AU - Meng,Anming, AU - Yang,Xiao, Y1 - 2006/09/16/ PY - 2006/07/11/received PY - 2006/09/01/revised PY - 2006/09/06/accepted PY - 2006/10/25/pubmed PY - 2007/6/1/medline PY - 2006/10/25/entrez SP - 54 EP - 7 JF - Matrix biology : journal of the International Society for Matrix Biology JO - Matrix Biol VL - 26 IS - 1 N2 - Brain microvascular endothelial cells (ECs) have unique characteristics distinguished from peripheral ECs and play important roles in blood-brain barrier (BBB). To investigate the physiological control of the brain ECs, we generated a transgenic mouse line in which the expression of Cre recombinase was driven by the promoter of the mouse surfactant protein A (SP-A) gene. The Cre activity was detected in blood vessels of brain, alveolar type II cells of lung and epithelium of gland stomach. In brain ECs, the Cre activity started at embryonic day 11.5, indicating that the subpopulation of ECs in brain could be molecularly defined at early embryonic stages. The use of SP-A-Cre mice should facilitate analysis of gene function in the brain ECs. SN - 0945-053X UR - https://www.unboundmedicine.com/medline/citation/17059883/Surfactant_protein_A_promoter_directs_the_expression_of_Cre_recombinase_in_brain_microvascular_endothelial_cells_of_transgenic_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0945-053X(06)00366-0 DB - PRIME DP - Unbound Medicine ER -