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Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: associations with diabetes and level of CKD.
Am J Kidney Dis. 2006 Nov; 48(5):720-6.AJ

Abstract

BACKGROUND

Racial and ethnic differences in prevalence of albuminuria in a nationally representative population with and without diabetes were assessed.

METHODS

We analyzed cross-sectional data collected for the 20,050 participants of the Third National Health and Nutrition Examination Survey (NHANES III) to determine factors that contributed to racial/ethnic differences in microalbuminuria and macroalbuminuria prevalence.

RESULTS

For the 15,522 NHANES III participants for whom relevant data were available, racial/ethnic minorities tended to be younger, be less well educated, have lower income, and be less likely to have insurance than non-Hispanic whites, findings that were similar for those with and without diabetes. After adjusting for baseline covariates and medication use, racial and ethnic minorities with and without diabetes had greater odds of albuminuria compared with whites without diabetes (blacks with diabetes, adjusted odds ratio [aOR], 2.77; 95% confidence interval [CI], 1.46 to 2.72), Mexican Americans with diabetes (aOR, 2.43; 95% CI, 1.07 to 2.11), and those of other ethnicity with diabetes (aOR, 2.93; 95% CI, 1.28 to 6.75). Of those without diabetes, blacks had 2.18-fold (95% CI, 1.44 to 3.30) and Mexican Americans had 1.81-fold (95% CI, 1.08 to 3.02) greater odds of microalbuminuria or macroalbuminuria than whites after adjustment for potential confounding factors. Stratifying by estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m(2) (<1.00 mL/s) showed similar results for racial/ethnic minorities and those with diabetes, whereas results were significant only for blacks with and without diabetes for those with an eGFR of 60 mL/min/1.73 m(2) or greater. Level of metabolic control (hemoglobin A(1c) level), systolic blood pressure, income, diuretic use, and hypertensive treatment status remained independent factors associated with albuminuria.

CONCLUSION

Racial and ethnic minorities have greater odds of albuminuria than whites with and without diabetes, which persists primarily for those with an eGFR less than 60 mL/min/1.73 m(2).

Authors+Show Affiliations

Epidemiologic Research and Information Center and Northwest Center of Excellence, Health Services Research and Development, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98101, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17059991

Citation

Bryson, Chris L., et al. "Racial and Ethnic Variations in Albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) Population: Associations With Diabetes and Level of CKD." American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, vol. 48, no. 5, 2006, pp. 720-6.
Bryson CL, Ross HJ, Boyko EJ, et al. Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: associations with diabetes and level of CKD. Am J Kidney Dis. 2006;48(5):720-6.
Bryson, C. L., Ross, H. J., Boyko, E. J., & Young, B. A. (2006). Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: associations with diabetes and level of CKD. American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation, 48(5), 720-6.
Bryson CL, et al. Racial and Ethnic Variations in Albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) Population: Associations With Diabetes and Level of CKD. Am J Kidney Dis. 2006;48(5):720-6. PubMed PMID: 17059991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Racial and ethnic variations in albuminuria in the US Third National Health and Nutrition Examination Survey (NHANES III) population: associations with diabetes and level of CKD. AU - Bryson,Chris L, AU - Ross,Heather J, AU - Boyko,Edward J, AU - Young,Bessie A, PY - 2005/12/05/received PY - 2006/07/20/accepted PY - 2006/10/25/pubmed PY - 2006/12/9/medline PY - 2006/10/25/entrez SP - 720 EP - 6 JF - American journal of kidney diseases : the official journal of the National Kidney Foundation JO - Am J Kidney Dis VL - 48 IS - 5 N2 - BACKGROUND: Racial and ethnic differences in prevalence of albuminuria in a nationally representative population with and without diabetes were assessed. METHODS: We analyzed cross-sectional data collected for the 20,050 participants of the Third National Health and Nutrition Examination Survey (NHANES III) to determine factors that contributed to racial/ethnic differences in microalbuminuria and macroalbuminuria prevalence. RESULTS: For the 15,522 NHANES III participants for whom relevant data were available, racial/ethnic minorities tended to be younger, be less well educated, have lower income, and be less likely to have insurance than non-Hispanic whites, findings that were similar for those with and without diabetes. After adjusting for baseline covariates and medication use, racial and ethnic minorities with and without diabetes had greater odds of albuminuria compared with whites without diabetes (blacks with diabetes, adjusted odds ratio [aOR], 2.77; 95% confidence interval [CI], 1.46 to 2.72), Mexican Americans with diabetes (aOR, 2.43; 95% CI, 1.07 to 2.11), and those of other ethnicity with diabetes (aOR, 2.93; 95% CI, 1.28 to 6.75). Of those without diabetes, blacks had 2.18-fold (95% CI, 1.44 to 3.30) and Mexican Americans had 1.81-fold (95% CI, 1.08 to 3.02) greater odds of microalbuminuria or macroalbuminuria than whites after adjustment for potential confounding factors. Stratifying by estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73 m(2) (<1.00 mL/s) showed similar results for racial/ethnic minorities and those with diabetes, whereas results were significant only for blacks with and without diabetes for those with an eGFR of 60 mL/min/1.73 m(2) or greater. Level of metabolic control (hemoglobin A(1c) level), systolic blood pressure, income, diuretic use, and hypertensive treatment status remained independent factors associated with albuminuria. CONCLUSION: Racial and ethnic minorities have greater odds of albuminuria than whites with and without diabetes, which persists primarily for those with an eGFR less than 60 mL/min/1.73 m(2). SN - 1523-6838 UR - https://www.unboundmedicine.com/medline/citation/17059991/Racial_and_ethnic_variations_in_albuminuria_in_the_US_Third_National_Health_and_Nutrition_Examination_Survey__NHANES_III__population:_associations_with_diabetes_and_level_of_CKD_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0272-6386(06)01229-7 DB - PRIME DP - Unbound Medicine ER -