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The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition.
Eur J Nutr. 2006 Oct; 45(7):399-405.EJ

Abstract

BACKGROUND

The nutritional control of ghrelin has not been fully clarified yet. Particularly, the influence of aminoacids and lipids is controversial and, moreover, whether the intraluminal gastric contact with nutrients is required or if the modulatory action of nutrients on ghrelin secretion is mediated by insulin is still matter of debate.

AIM OF THE STUDY

To clarify the role of nutrients in the control of ghrelin secretion evaluating the effects of intravenous and oral lipids and aminoacids compared with glucose and fructose load in healthy subjects.

METHODS

A total of 6 healthy overnight-fasted volunteers underwent the following testing sessions: (a) iv arginine (ARG, 0.5 g/kg); (b) oral protein load (PRO, 50 g); (c) iv lipid-heparin infusion (Li He, Intralipid 10% 250 ml); (d) oral fat load (OIL, soy oil 40 g); (e) oral glucose load (OGL, 100 g); (f) oral fructose load (OFL, 100 g); (g) iv saline (SAL, 3 ml); (h) oral water load (WL, 200 ml). Total ghrelin, insulin, and glucose were assayed every 15 min from 0 up to +180 min.

RESULTS

WL and SAL did not modify insulin, glucose and ghrelin. ARG induced a prompt but transient increase (P < 0.05) of insulin and glucose (P < 0.01), without modifying ghrelin secretion. PRO induced a mild but sustained increase of insulin secretion (P < 0.05) without affecting glucose and ghrelin. Li-He progressively increased circulating glucose (P < 0.01) without modifying insulin and ghrelin secretion. No significant variations in circulating glucose, insulin, and ghrelin occurred after OIL. OGL significantly (P < 0.01) increased insulin and glucose levels and progressively decreased (P < 0.05) ghrelin levels. OFL induced a mild (P < 0.05) increase of insulin without modifying glucose levels. Similarly, OFL was followed by a milder decrease (P < 0.05) of ghrelin levels.

CONCLUSIONS

Differently from carbohydrates and independently from their modulatory effect on insulin secretion and glucose levels, both lipids and aminoacids play a negligible role in the acute control of ghrelin secretion either after acute enteral and parenteral administration.

Authors+Show Affiliations

Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, c.so Dogliotti, 14 Turin, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17061019

Citation

Prodam, Flavia, et al. "The Nutritional Control of Ghrelin Secretion in Humans: the Effects of Enteral Vs. Parenteral Nutrition." European Journal of Nutrition, vol. 45, no. 7, 2006, pp. 399-405.
Prodam F, Me E, Riganti F, et al. The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition. Eur J Nutr. 2006;45(7):399-405.
Prodam, F., Me, E., Riganti, F., Gramaglia, E., Bellone, S., Baldelli, R., Rapa, A., van der Lely, A. J., Bona, G., Ghigo, E., & Broglio, F. (2006). The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition. European Journal of Nutrition, 45(7), 399-405.
Prodam F, et al. The Nutritional Control of Ghrelin Secretion in Humans: the Effects of Enteral Vs. Parenteral Nutrition. Eur J Nutr. 2006;45(7):399-405. PubMed PMID: 17061019.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The nutritional control of ghrelin secretion in humans: the effects of enteral vs. parenteral nutrition. AU - Prodam,Flavia, AU - Me,Elisa, AU - Riganti,Fabrizio, AU - Gramaglia,Elena, AU - Bellone,Simonetta, AU - Baldelli,Roberto, AU - Rapa,Anna, AU - van der Lely,Aart Jan, AU - Bona,Gianni, AU - Ghigo,Ezio, AU - Broglio,Fabio, Y1 - 2006/09/07/ PY - 2006/01/11/received PY - 2006/08/02/accepted PY - 2006/10/25/pubmed PY - 2007/5/30/medline PY - 2006/10/25/entrez SP - 399 EP - 405 JF - European journal of nutrition JO - Eur J Nutr VL - 45 IS - 7 N2 - BACKGROUND: The nutritional control of ghrelin has not been fully clarified yet. Particularly, the influence of aminoacids and lipids is controversial and, moreover, whether the intraluminal gastric contact with nutrients is required or if the modulatory action of nutrients on ghrelin secretion is mediated by insulin is still matter of debate. AIM OF THE STUDY: To clarify the role of nutrients in the control of ghrelin secretion evaluating the effects of intravenous and oral lipids and aminoacids compared with glucose and fructose load in healthy subjects. METHODS: A total of 6 healthy overnight-fasted volunteers underwent the following testing sessions: (a) iv arginine (ARG, 0.5 g/kg); (b) oral protein load (PRO, 50 g); (c) iv lipid-heparin infusion (Li He, Intralipid 10% 250 ml); (d) oral fat load (OIL, soy oil 40 g); (e) oral glucose load (OGL, 100 g); (f) oral fructose load (OFL, 100 g); (g) iv saline (SAL, 3 ml); (h) oral water load (WL, 200 ml). Total ghrelin, insulin, and glucose were assayed every 15 min from 0 up to +180 min. RESULTS: WL and SAL did not modify insulin, glucose and ghrelin. ARG induced a prompt but transient increase (P < 0.05) of insulin and glucose (P < 0.01), without modifying ghrelin secretion. PRO induced a mild but sustained increase of insulin secretion (P < 0.05) without affecting glucose and ghrelin. Li-He progressively increased circulating glucose (P < 0.01) without modifying insulin and ghrelin secretion. No significant variations in circulating glucose, insulin, and ghrelin occurred after OIL. OGL significantly (P < 0.01) increased insulin and glucose levels and progressively decreased (P < 0.05) ghrelin levels. OFL induced a mild (P < 0.05) increase of insulin without modifying glucose levels. Similarly, OFL was followed by a milder decrease (P < 0.05) of ghrelin levels. CONCLUSIONS: Differently from carbohydrates and independently from their modulatory effect on insulin secretion and glucose levels, both lipids and aminoacids play a negligible role in the acute control of ghrelin secretion either after acute enteral and parenteral administration. SN - 1436-6207 UR - https://www.unboundmedicine.com/medline/citation/17061019/The_nutritional_control_of_ghrelin_secretion_in_humans:_the_effects_of_enteral_vs__parenteral_nutrition_ L2 - https://dx.doi.org/10.1007/s00394-006-0613-z DB - PRIME DP - Unbound Medicine ER -