Tags

Type your tag names separated by a space and hit enter

Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis.
Arthritis Res Ther. 2006; 8(6):R162.AR

Abstract

This study investigated the overall clinical impact of anti-alpha-actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)-positive individuals. The relation of anti-alpha-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional design, the presence of antibodies to alpha-actinin was studied in selected groups, classified according to the relevant American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) (n = 99), rheumatoid arthritis (RA) (n = 68), Wegener's granulomatosis (WG) (n = 85), and fibromyalgia (FM) (n = 29), and in a random group of ANA-positive individuals (n = 142). Renal disease was defined as (increased) proteinuria with haematuria or presence of cellular casts. Sera from SLE, RA, and Sjøgren's syndrome (SS) patients had significantly higher levels of anti-alpha-actinin antibodies than the other patient groups. Using the geometric mean (+/- 2 standard deviations) in FM patients as the upper cutoff, 20% of SLE patients, 12% of RA patients, 4% of SS patients, and none of the WG patients were positive for anti-alpha-actinin antibodies. Within the SLE cohort, anti-alpha-actinin antibody levels were higher in patients with renal flares (p = 0.02) and correlated independently with anti-dsDNA antibody levels by enzyme-linked immunosorbent assay (p < 0.007) but not with other disease features. In the random ANA group, 14 individuals had anti-alpha-actinin antibodies. Of these, 36% had SLE, while 64% suffered from other, mostly autoimmune, disorders. Antibodies binding to alpha-actinin were detected in 20% of SLE patients but were not specific for SLE. They correlate with anti-dsDNA antibody levels, implying in vitro cross-reactivity of anti-dsDNA antibodies, which may explain the observed association with renal disease in SLE.

Authors+Show Affiliations

Department of Rheumatology, Institute of Clinical Medicine, University of Tromsø, Breivika, N-9037 Tromsø, Norway. andrea.becker-merok@unn.noNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17062137

Citation

Becker-Merok, Andrea, et al. "Alpha-actinin-binding Antibodies in Relation to Systemic Lupus Erythematosus and Lupus Nephritis." Arthritis Research & Therapy, vol. 8, no. 6, 2006, pp. R162.
Becker-Merok A, Kalaaji M, Haugbro K, et al. Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis. Arthritis Res Ther. 2006;8(6):R162.
Becker-Merok, A., Kalaaji, M., Haugbro, K., Nikolaisen, C., Nilsen, K., Rekvig, O. P., & Nossent, J. C. (2006). Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis. Arthritis Research & Therapy, 8(6), R162.
Becker-Merok A, et al. Alpha-actinin-binding Antibodies in Relation to Systemic Lupus Erythematosus and Lupus Nephritis. Arthritis Res Ther. 2006;8(6):R162. PubMed PMID: 17062137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alpha-actinin-binding antibodies in relation to systemic lupus erythematosus and lupus nephritis. AU - Becker-Merok,Andrea, AU - Kalaaji,Manar, AU - Haugbro,Kaia, AU - Nikolaisen,Cathrin, AU - Nilsen,Kirsten, AU - Rekvig,Ole Petter, AU - Nossent,Johannes C, PY - 2006/06/19/received PY - 2006/09/25/revised PY - 2006/10/24/accepted PY - 2006/10/26/pubmed PY - 2007/2/24/medline PY - 2006/10/26/entrez SP - R162 EP - R162 JF - Arthritis research & therapy JO - Arthritis Res. Ther. VL - 8 IS - 6 N2 - This study investigated the overall clinical impact of anti-alpha-actinin antibodies in patients with pre-selected autoimmune diseases and in a random group of anti-nuclear antibody (ANA)-positive individuals. The relation of anti-alpha-actinin antibodies with lupus nephritis and anti-double-stranded DNA (anti-dsDNA) antibodies represented a particular focus for the study. Using a cross-sectional design, the presence of antibodies to alpha-actinin was studied in selected groups, classified according to the relevant American College of Rheumatology classification criteria for systemic lupus erythematosus (SLE) (n = 99), rheumatoid arthritis (RA) (n = 68), Wegener's granulomatosis (WG) (n = 85), and fibromyalgia (FM) (n = 29), and in a random group of ANA-positive individuals (n = 142). Renal disease was defined as (increased) proteinuria with haematuria or presence of cellular casts. Sera from SLE, RA, and Sjøgren's syndrome (SS) patients had significantly higher levels of anti-alpha-actinin antibodies than the other patient groups. Using the geometric mean (+/- 2 standard deviations) in FM patients as the upper cutoff, 20% of SLE patients, 12% of RA patients, 4% of SS patients, and none of the WG patients were positive for anti-alpha-actinin antibodies. Within the SLE cohort, anti-alpha-actinin antibody levels were higher in patients with renal flares (p = 0.02) and correlated independently with anti-dsDNA antibody levels by enzyme-linked immunosorbent assay (p < 0.007) but not with other disease features. In the random ANA group, 14 individuals had anti-alpha-actinin antibodies. Of these, 36% had SLE, while 64% suffered from other, mostly autoimmune, disorders. Antibodies binding to alpha-actinin were detected in 20% of SLE patients but were not specific for SLE. They correlate with anti-dsDNA antibody levels, implying in vitro cross-reactivity of anti-dsDNA antibodies, which may explain the observed association with renal disease in SLE. SN - 1478-6362 UR - https://www.unboundmedicine.com/medline/citation/17062137/Alpha_actinin_binding_antibodies_in_relation_to_systemic_lupus_erythematosus_and_lupus_nephritis_ L2 - https://arthritis-research.biomedcentral.com/articles/10.1186/ar2070 DB - PRIME DP - Unbound Medicine ER -