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Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis.
Hum Reprod. 2007 Mar; 22(3):836-42.HR

Abstract

BACKGROUND

There is a need for a reliable marker of endometriosis, especially in early stages of peritoneal disease during which imaging is not effective. The use of serum interleukin (IL)-6 as a marker is controversial. To readdress the matter, patients undergoing laparoscopy were prospectively evaluated for serum IL-6 levels.

MATERIALS AND METHODS

A total of 119 women 31 years old who underwent laparoscopy were divided into groups: control patients (n = 38) with no pathologic findings; endometriosis sufferers (n = 47) with minimal-mild (MM, n = 11) or moderate-severe (MS, n = 36) endometriosis; uterine myomas (n = 13) and benign ovarian pathologies (n = 21). Blood was drawn on cycles days 5-12 and stored for subsequent analysis of IL-6 and carbohydrate antigen (CA)-125 levels.

RESULTS

Serum IL-6 levels were significantly (P = 0.002) higher in women with MM endometriosis (29.4 9.0 pg/ml) than in controls (15.7 9.3 pg/ml). When all the non-endometriosis patients were grouped together (n = 72) and serum IL-6 (17.8 12.1 pg/ml) compared with MS (n = 36; 17.6 10.3 pg/ml) and MM (n = 11; 29.4 9.0 pg/ml) endometriosis significantly (P < 0.01) higher levels in MM endometriosis were observed as compared to the other two groups. Serum Ca-125 levels were significantly (P < 0.01) elevated in MS endometriosis. A serum IL-6 threshold of 25.75 pg/ml afforded a sensitivity of 75% and specificity of 83% in the diagnosis of MM endometriosis. Sensitivity and specificity for CA-125 in the diagnosis of MS endometriosis, using 35 IU/ml as the cut-off value, were 47% and 97%, respectively.

CONCLUSIONS

IL-6 is a reliable non-invasive marker of MM endometriosis, whereas Ca-125 is of use as a marker of severe cases.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Hospital Universitario Dr Peset, University of Valencia, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17062580

Citation

Martínez, S, et al. "Serum Interleukin-6 Levels Are Elevated in Women With Minimal-mild Endometriosis." Human Reproduction (Oxford, England), vol. 22, no. 3, 2007, pp. 836-42.
Martínez S, Garrido N, Coperias JL, et al. Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. Hum Reprod. 2007;22(3):836-42.
Martínez, S., Garrido, N., Coperias, J. L., Pardo, F., Desco, J., García-Velasco, J. A., Simón, C., & Pellicer, A. (2007). Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. Human Reproduction (Oxford, England), 22(3), 836-42.
Martínez S, et al. Serum Interleukin-6 Levels Are Elevated in Women With Minimal-mild Endometriosis. Hum Reprod. 2007;22(3):836-42. PubMed PMID: 17062580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum interleukin-6 levels are elevated in women with minimal-mild endometriosis. AU - Martínez,S, AU - Garrido,N, AU - Coperias,J L, AU - Pardo,F, AU - Desco,J, AU - García-Velasco,J A, AU - Simón,C, AU - Pellicer,A, Y1 - 2006/10/24/ PY - 2006/10/26/pubmed PY - 2007/5/5/medline PY - 2006/10/26/entrez SP - 836 EP - 42 JF - Human reproduction (Oxford, England) JO - Hum Reprod VL - 22 IS - 3 N2 - BACKGROUND: There is a need for a reliable marker of endometriosis, especially in early stages of peritoneal disease during which imaging is not effective. The use of serum interleukin (IL)-6 as a marker is controversial. To readdress the matter, patients undergoing laparoscopy were prospectively evaluated for serum IL-6 levels. MATERIALS AND METHODS: A total of 119 women 31 years old who underwent laparoscopy were divided into groups: control patients (n = 38) with no pathologic findings; endometriosis sufferers (n = 47) with minimal-mild (MM, n = 11) or moderate-severe (MS, n = 36) endometriosis; uterine myomas (n = 13) and benign ovarian pathologies (n = 21). Blood was drawn on cycles days 5-12 and stored for subsequent analysis of IL-6 and carbohydrate antigen (CA)-125 levels. RESULTS: Serum IL-6 levels were significantly (P = 0.002) higher in women with MM endometriosis (29.4 9.0 pg/ml) than in controls (15.7 9.3 pg/ml). When all the non-endometriosis patients were grouped together (n = 72) and serum IL-6 (17.8 12.1 pg/ml) compared with MS (n = 36; 17.6 10.3 pg/ml) and MM (n = 11; 29.4 9.0 pg/ml) endometriosis significantly (P < 0.01) higher levels in MM endometriosis were observed as compared to the other two groups. Serum Ca-125 levels were significantly (P < 0.01) elevated in MS endometriosis. A serum IL-6 threshold of 25.75 pg/ml afforded a sensitivity of 75% and specificity of 83% in the diagnosis of MM endometriosis. Sensitivity and specificity for CA-125 in the diagnosis of MS endometriosis, using 35 IU/ml as the cut-off value, were 47% and 97%, respectively. CONCLUSIONS: IL-6 is a reliable non-invasive marker of MM endometriosis, whereas Ca-125 is of use as a marker of severe cases. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/17062580/Serum_interleukin_6_levels_are_elevated_in_women_with_minimal_mild_endometriosis_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/del419 DB - PRIME DP - Unbound Medicine ER -