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Breast cancer: bisphosphonate therapy for metastatic bone disease.
Clin Cancer Res. 2006 Oct 15; 12(20 Pt 2):6258s-6263s.CC

Abstract

The indications of bisphosphonate therapy in breast cancer patients go from the correction of hypercalcemia to the prevention of cancer treatment-induced bone loss. Bisphosphonates are part of our therapeutic armamentarium against metastatic bone pain, and at least 50% of the patients benefit from a clinically relevant analgesic effect. Placebo-controlled trials with oral or i.v. bisphosphonates have shown that prolonged administration can reduce the frequency of skeletal-related events by 30% to 40%. The superiority of zoledronic acid compared with pamidronate has been shown by a multiple-event analysis in a large randomized trial. The short infusion time of zoledronic acid also constitutes a convenient therapy. Where available, oral ibandronate offers an interesting alternative, especially for patients receiving hormone therapy. There are some toxicity concerns with the prolonged use of bisphosphonates. The occasional renal toxicity of zoledronic acid has led to the recommendation to monitor renal function before each infusion and to adjust the dose according to creatinine clearance. Osteonecrosis of the jaw could occur in up to 2.5% of breast cancer patients during long-term bisphosphonate therapy. It is often a significant complication that seems to be linked with the duration of therapy.

Authors+Show Affiliations

Department of Internal Medicine, Institut Jules Bordet, Univesité Libre de Bruxelles, Brussels, Belgium.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17062710

Citation

Body, Jean-Jacques. "Breast Cancer: Bisphosphonate Therapy for Metastatic Bone Disease." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, vol. 12, no. 20 Pt 2, 2006, 6258s-6263s.
Body JJ. Breast cancer: bisphosphonate therapy for metastatic bone disease. Clin Cancer Res. 2006;12(20 Pt 2):6258s-6263s.
Body, J. J. (2006). Breast cancer: bisphosphonate therapy for metastatic bone disease. Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 12(20 Pt 2), 6258s-6263s.
Body JJ. Breast Cancer: Bisphosphonate Therapy for Metastatic Bone Disease. Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6258s-6263s. PubMed PMID: 17062710.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer: bisphosphonate therapy for metastatic bone disease. A1 - Body,Jean-Jacques, PY - 2006/10/26/pubmed PY - 2006/12/9/medline PY - 2006/10/26/entrez SP - 6258s EP - 6263s JF - Clinical cancer research : an official journal of the American Association for Cancer Research JO - Clin Cancer Res VL - 12 IS - 20 Pt 2 N2 - The indications of bisphosphonate therapy in breast cancer patients go from the correction of hypercalcemia to the prevention of cancer treatment-induced bone loss. Bisphosphonates are part of our therapeutic armamentarium against metastatic bone pain, and at least 50% of the patients benefit from a clinically relevant analgesic effect. Placebo-controlled trials with oral or i.v. bisphosphonates have shown that prolonged administration can reduce the frequency of skeletal-related events by 30% to 40%. The superiority of zoledronic acid compared with pamidronate has been shown by a multiple-event analysis in a large randomized trial. The short infusion time of zoledronic acid also constitutes a convenient therapy. Where available, oral ibandronate offers an interesting alternative, especially for patients receiving hormone therapy. There are some toxicity concerns with the prolonged use of bisphosphonates. The occasional renal toxicity of zoledronic acid has led to the recommendation to monitor renal function before each infusion and to adjust the dose according to creatinine clearance. Osteonecrosis of the jaw could occur in up to 2.5% of breast cancer patients during long-term bisphosphonate therapy. It is often a significant complication that seems to be linked with the duration of therapy. SN - 1078-0432 UR - https://www.unboundmedicine.com/medline/citation/17062710/Breast_cancer:_bisphosphonate_therapy_for_metastatic_bone_disease_ L2 - http://clincancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=17062710 DB - PRIME DP - Unbound Medicine ER -