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Rise of plasma ghrelin with weight loss is not sustained during weight maintenance.
Obesity (Silver Spring). 2006 Oct; 14(10):1716-23.O

Abstract

OBJECTIVE

Ghrelin is postulated to be an orexigenic signal that promotes weight regain after weight loss (WL). However, it is not known whether this putative effect of ghrelin is sustained after weight stabilization. The objective of this study was to investigate the relationship of plasma ghrelin concentrations to active WL and weight maintenance in obese subjects.

RESEARCH METHODS AND PROCEDURES

This study was a randomized clinical trial, with a 12-month follow-up period. Obese Mexican-American women matched for age and BMI were randomized to a 12-month WL program (n = 25) or no intervention (controls, n = 23). Interventions included diet, exercise, and orlistat. Body weight and fasting ghrelin, leptin, insulin, and glucose concentrations were measured at baseline and 6 and 12 months.

RESULTS

The WL group lost 8.5% of body weight after 6 months and maintained the new weight for the next 6 months. Ghrelin concentrations increased significantly at 6 months but returned to baseline at 12 months. Baseline ghrelin concentrations were directly related to the degree of WL achieved after 12 months. Controls experienced no change in BMI or ghrelin levels. There were no associations between plasma ghrelin and leptin or insulin concentrations.

DISCUSSION

Consistent with previous results, ghrelin rises in response to WL, perhaps as a counterregulatory mechanism. However, the present results indicate that ghrelin concentrations return to baseline with sustained weight maintenance, suggesting that its effects are unlikely to regulate long-term energy balance. Baseline ghrelin concentrations are related to the degree of WL that can be achieved by active weight reduction.

Authors+Show Affiliations

Translational Metabolism Unit, Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX 77030, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17062800

Citation

Garcia, Jose M., et al. "Rise of Plasma Ghrelin With Weight Loss Is Not Sustained During Weight Maintenance." Obesity (Silver Spring, Md.), vol. 14, no. 10, 2006, pp. 1716-23.
Garcia JM, Iyer D, Poston WS, et al. Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. Obesity (Silver Spring). 2006;14(10):1716-23.
Garcia, J. M., Iyer, D., Poston, W. S., Marcelli, M., Reeves, R., Foreyt, J., & Balasubramanyam, A. (2006). Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. Obesity (Silver Spring, Md.), 14(10), 1716-23.
Garcia JM, et al. Rise of Plasma Ghrelin With Weight Loss Is Not Sustained During Weight Maintenance. Obesity (Silver Spring). 2006;14(10):1716-23. PubMed PMID: 17062800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. AU - Garcia,Jose M, AU - Iyer,Dinakar, AU - Poston,Walker S C, AU - Marcelli,Marco, AU - Reeves,Rebecca, AU - Foreyt,John, AU - Balasubramanyam,Ashok, PY - 2006/10/26/pubmed PY - 2006/12/27/medline PY - 2006/10/26/entrez SP - 1716 EP - 23 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 IS - 10 N2 - OBJECTIVE: Ghrelin is postulated to be an orexigenic signal that promotes weight regain after weight loss (WL). However, it is not known whether this putative effect of ghrelin is sustained after weight stabilization. The objective of this study was to investigate the relationship of plasma ghrelin concentrations to active WL and weight maintenance in obese subjects. RESEARCH METHODS AND PROCEDURES: This study was a randomized clinical trial, with a 12-month follow-up period. Obese Mexican-American women matched for age and BMI were randomized to a 12-month WL program (n = 25) or no intervention (controls, n = 23). Interventions included diet, exercise, and orlistat. Body weight and fasting ghrelin, leptin, insulin, and glucose concentrations were measured at baseline and 6 and 12 months. RESULTS: The WL group lost 8.5% of body weight after 6 months and maintained the new weight for the next 6 months. Ghrelin concentrations increased significantly at 6 months but returned to baseline at 12 months. Baseline ghrelin concentrations were directly related to the degree of WL achieved after 12 months. Controls experienced no change in BMI or ghrelin levels. There were no associations between plasma ghrelin and leptin or insulin concentrations. DISCUSSION: Consistent with previous results, ghrelin rises in response to WL, perhaps as a counterregulatory mechanism. However, the present results indicate that ghrelin concentrations return to baseline with sustained weight maintenance, suggesting that its effects are unlikely to regulate long-term energy balance. Baseline ghrelin concentrations are related to the degree of WL that can be achieved by active weight reduction. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/17062800/Rise_of_plasma_ghrelin_with_weight_loss_is_not_sustained_during_weight_maintenance_ L2 - https://doi.org/10.1038/oby.2006.197 DB - PRIME DP - Unbound Medicine ER -