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Stability of vancomycin in icodextrin peritoneal dialysis solution.
Ann Pharmacother 2006; 40(11):1950-4AP

Abstract

BACKGROUND

Icodextrin is a glucose polymer used as an alternative osmotic agent in peritoneal dialysis (PD) solutions. There are few data regarding the long-term stability of vancomycin in icodextrin PD solution.

OBJECTIVE

To determine the chemical stability of vancomycin in icodextrin PD solution in polyvinyl chloride containers over a 7 day period at 4, 24, and 37 degrees C.

METHODS

Study samples were prepared by adding 2000 mg vancomycin HCl to commercially available 2.0 L bags of icodextrin 7.5% PD solution. Nine bags were prepared and stored in the following conditions: 3 under refrigeration (5 degrees C), 3 at room temperature (24 degrees C), and 3 at body temperature (37 degrees C). Samples were withdrawn from each bag immediately after preparation and at predetermined intervals over the subsequent 7 days. Solutions were visually inspected for precipitation, cloudiness, or discoloration at each sampling interval. Total concentration of vancomycin in dialysate fluid was determined by high performance liquid chromatography.

RESULTS

Under refrigeration, a mean +/- SD of 99.7% +/- 0.5% of the initial vancomycin concentration remained at 168 hours (7 days). At room temperature, 97.5% +/- 3.4% remained at 168 hours. At body temperature, 94.3% +/- 3.9% remained at 24 hours. Stability was not assessed beyond these time points.

CONCLUSIONS

Premixed vancomycin-icodextrin PD solutions, whether stored refrigerated or at room temperature, were found to be stable for up to 7 days. However, we recommend that these solutions be kept refrigerated whenever possible. Solutions stored at body temperature were stable for up to 24 hours, permitting the practice of prewarming solutions prior to administration.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Albany College of Pharmacy, Albany, NY 12208-3492, USA. nornooa@acp.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17062839

Citation

Nornoo, Adwoa O., and Rowland J. Elwell. "Stability of Vancomycin in Icodextrin Peritoneal Dialysis Solution." The Annals of Pharmacotherapy, vol. 40, no. 11, 2006, pp. 1950-4.
Nornoo AO, Elwell RJ. Stability of vancomycin in icodextrin peritoneal dialysis solution. Ann Pharmacother. 2006;40(11):1950-4.
Nornoo, A. O., & Elwell, R. J. (2006). Stability of vancomycin in icodextrin peritoneal dialysis solution. The Annals of Pharmacotherapy, 40(11), pp. 1950-4.
Nornoo AO, Elwell RJ. Stability of Vancomycin in Icodextrin Peritoneal Dialysis Solution. Ann Pharmacother. 2006;40(11):1950-4. PubMed PMID: 17062839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Stability of vancomycin in icodextrin peritoneal dialysis solution. AU - Nornoo,Adwoa O, AU - Elwell,Rowland J, Y1 - 2006/10/24/ PY - 2006/10/26/pubmed PY - 2007/1/9/medline PY - 2006/10/26/entrez SP - 1950 EP - 4 JF - The Annals of pharmacotherapy JO - Ann Pharmacother VL - 40 IS - 11 N2 - BACKGROUND: Icodextrin is a glucose polymer used as an alternative osmotic agent in peritoneal dialysis (PD) solutions. There are few data regarding the long-term stability of vancomycin in icodextrin PD solution. OBJECTIVE: To determine the chemical stability of vancomycin in icodextrin PD solution in polyvinyl chloride containers over a 7 day period at 4, 24, and 37 degrees C. METHODS: Study samples were prepared by adding 2000 mg vancomycin HCl to commercially available 2.0 L bags of icodextrin 7.5% PD solution. Nine bags were prepared and stored in the following conditions: 3 under refrigeration (5 degrees C), 3 at room temperature (24 degrees C), and 3 at body temperature (37 degrees C). Samples were withdrawn from each bag immediately after preparation and at predetermined intervals over the subsequent 7 days. Solutions were visually inspected for precipitation, cloudiness, or discoloration at each sampling interval. Total concentration of vancomycin in dialysate fluid was determined by high performance liquid chromatography. RESULTS: Under refrigeration, a mean +/- SD of 99.7% +/- 0.5% of the initial vancomycin concentration remained at 168 hours (7 days). At room temperature, 97.5% +/- 3.4% remained at 168 hours. At body temperature, 94.3% +/- 3.9% remained at 24 hours. Stability was not assessed beyond these time points. CONCLUSIONS: Premixed vancomycin-icodextrin PD solutions, whether stored refrigerated or at room temperature, were found to be stable for up to 7 days. However, we recommend that these solutions be kept refrigerated whenever possible. Solutions stored at body temperature were stable for up to 24 hours, permitting the practice of prewarming solutions prior to administration. SN - 1542-6270 UR - https://www.unboundmedicine.com/medline/citation/17062839/Stability_of_vancomycin_in_icodextrin_peritoneal_dialysis_solution_ L2 - http://journals.sagepub.com/doi/full/10.1345/aph.1G321?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -