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Identification of the first strain of swine hepatitis E virus in South America and prevalence of anti-HEV antibodies in swine in Argentina.
J Med Virol. 2006 Dec; 78(12):1579-83.JM

Abstract

In Argentina, a country considered non-endemic for hepatitis E virus (HEV) infection, serologic evidence of HEV infection has been observed in different human population groups. In other countries, a high degree of genetic relatedness has been observed between human and swine HEV genotype 3 sequences, suggesting zoonosis as one probable route of infection. This is the first identification of swine HEV in South America. HEV RNA was detected and sequenced in the ORF 1 and ORF 2 regions from swine fecal samples from a herd located in Pergamino, in the province of Buenos Aires. These strains all group into genotype 3 and exhibit a close relationship to two novel HEV variants previously identified in Argentina from sporadic acute cases of non-A to -C hepatitis in humans. In addition, using a modified commercial ELISA, the presence of anti-HEV antibodies was surveyed in five provinces across the country and all five showed a prevalence of HEV antibodies, ranging from 4% to 58%. The results suggest that swine could be an important reservoir for virus transmission in Argentina as has been suggested for other non-endemic areas. The Argentine human strains and swine strain described in this article seem to be closely related to a human Austrian strain, suggesting a potential European origin of HEV infection in these cases.

Authors+Show Affiliations

Nacional Reference Lab for Viral Hepatitis, National Institute of Infectious Diseases, ANLIS "Dr C.G. Malbrán", Buenos Aires, Argentina. smunne@anlis.gov.arNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17063523

Citation

Munné, María S., et al. "Identification of the First Strain of Swine Hepatitis E Virus in South America and Prevalence of anti-HEV Antibodies in Swine in Argentina." Journal of Medical Virology, vol. 78, no. 12, 2006, pp. 1579-83.
Munné MS, Vladimirsky S, Otegui L, et al. Identification of the first strain of swine hepatitis E virus in South America and prevalence of anti-HEV antibodies in swine in Argentina. J Med Virol. 2006;78(12):1579-83.
Munné, M. S., Vladimirsky, S., Otegui, L., Castro, R., Brajterman, L., Soto, S., Guarnera, E., Molina, V., Monfellano, M., Schlauder, G. G., & González, J. E. (2006). Identification of the first strain of swine hepatitis E virus in South America and prevalence of anti-HEV antibodies in swine in Argentina. Journal of Medical Virology, 78(12), 1579-83.
Munné MS, et al. Identification of the First Strain of Swine Hepatitis E Virus in South America and Prevalence of anti-HEV Antibodies in Swine in Argentina. J Med Virol. 2006;78(12):1579-83. PubMed PMID: 17063523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of the first strain of swine hepatitis E virus in South America and prevalence of anti-HEV antibodies in swine in Argentina. AU - Munné,María S, AU - Vladimirsky,Sara, AU - Otegui,Lucio, AU - Castro,Raúl, AU - Brajterman,Leonardo, AU - Soto,Sonia, AU - Guarnera,Eduardo, AU - Molina,Viviana, AU - Monfellano,Marcela, AU - Schlauder,George G, AU - González,Jorge E, PY - 2006/10/26/pubmed PY - 2007/1/11/medline PY - 2006/10/26/entrez SP - 1579 EP - 83 JF - Journal of medical virology JO - J Med Virol VL - 78 IS - 12 N2 - In Argentina, a country considered non-endemic for hepatitis E virus (HEV) infection, serologic evidence of HEV infection has been observed in different human population groups. In other countries, a high degree of genetic relatedness has been observed between human and swine HEV genotype 3 sequences, suggesting zoonosis as one probable route of infection. This is the first identification of swine HEV in South America. HEV RNA was detected and sequenced in the ORF 1 and ORF 2 regions from swine fecal samples from a herd located in Pergamino, in the province of Buenos Aires. These strains all group into genotype 3 and exhibit a close relationship to two novel HEV variants previously identified in Argentina from sporadic acute cases of non-A to -C hepatitis in humans. In addition, using a modified commercial ELISA, the presence of anti-HEV antibodies was surveyed in five provinces across the country and all five showed a prevalence of HEV antibodies, ranging from 4% to 58%. The results suggest that swine could be an important reservoir for virus transmission in Argentina as has been suggested for other non-endemic areas. The Argentine human strains and swine strain described in this article seem to be closely related to a human Austrian strain, suggesting a potential European origin of HEV infection in these cases. SN - 0146-6615 UR - https://www.unboundmedicine.com/medline/citation/17063523/Identification_of_the_first_strain_of_swine_hepatitis_E_virus_in_South_America_and_prevalence_of_anti_HEV_antibodies_in_swine_in_Argentina_ L2 - https://doi.org/10.1002/jmv.20741 DB - PRIME DP - Unbound Medicine ER -