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Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis.
Clin Nephrol. 2006 Oct; 66(4):247-55.CN

Abstract

The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers.

METHOD

This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism.

RESULTS

Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3.

CONCLUSION

We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation.

Authors+Show Affiliations

Inonu University Medical School, Department of Medicine, Division of Nephrology, Malatya, Turkey. hulyataskapan@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17063991

Citation

Taskapan, H, et al. "Severe Vitamin D Deficiency in Chronic Renal Failure Patients On Peritoneal Dialysis." Clinical Nephrology, vol. 66, no. 4, 2006, pp. 247-55.
Taskapan H, Ersoy FF, Passadakis PS, et al. Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis. Clin Nephrol. 2006;66(4):247-55.
Taskapan, H., Ersoy, F. F., Passadakis, P. S., Tam, P., Memmos, D. E., Katopodis, K. P., Ozener, C., Akcicek, F., Camsari, T., Ates, K., Ataman, R., Vlachojannis, J. G., Dombros, N. A., Utas, C., Akpolat, T., Bozfakioglu, S., Wu, G., Karayaylali, I., Arinsoy, T., ... Oreopoulos, D. G. (2006). Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis. Clinical Nephrology, 66(4), 247-55.
Taskapan H, et al. Severe Vitamin D Deficiency in Chronic Renal Failure Patients On Peritoneal Dialysis. Clin Nephrol. 2006;66(4):247-55. PubMed PMID: 17063991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe vitamin D deficiency in chronic renal failure patients on peritoneal dialysis. AU - Taskapan,H, AU - Ersoy,F F, AU - Passadakis,P S, AU - Tam,P, AU - Memmos,D E, AU - Katopodis,K P, AU - Ozener,C, AU - Akcicek,F, AU - Camsari,T, AU - Ates,K, AU - Ataman,R, AU - Vlachojannis,J G, AU - Dombros,N A, AU - Utas,C, AU - Akpolat,T, AU - Bozfakioglu,S, AU - Wu,G, AU - Karayaylali,I, AU - Arinsoy,T, AU - Stathakis,C P, AU - Yavuz,M, AU - Tsakiris,D J, AU - Dimitriades,A D, AU - Yilmaz,M E, AU - Gültekin,M, AU - Oreopoulos,D G, PY - 2006/10/27/pubmed PY - 2007/2/6/medline PY - 2006/10/27/entrez SP - 247 EP - 55 JF - Clinical nephrology JO - Clin Nephrol VL - 66 IS - 4 N2 - UNLABELLED: The aim of this study was to evaluate the prevalence of vitamin D deficiency in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with various demographic and renal osteodystrophy markers. METHOD: This cross-sectional, multicenter study was carried out in 273 PD patients with a mean age of 61.7 +/- 10.9 years and mean duration of PD 3.3 +/- 2.2 years. It included 123 female and 150 male patients from 20 centers in Greece and Turkey, countries that are on the same latitude, namely, 36-42 degrees north. We measured 25(OH)D3 and 1.25(OH)2D3 levels and some other clinical and laboratory indices of bone mineral metabolism. RESULTS: Of these 273 patients 92% (251 patients) had vitamin D deficiency i.e. serum 25(OH)D3 levels less than 15 ng/ml, 119 (43.6%) had severe vitamin D deficiency i.e., serum 25(OH)D3 levels, less than 5 ng/ml, 132 (48.4%) had moderate vitamin D deficiency i.e., serum 25(OH)D3 levels, 5-15 ng/ml, 12 (4.4%) vitamin D insufficiency i.e., serum 25(OH)D3 levels 15 - 30 ng/ml and only 10 (3.6%) had adequate vitamin D stores. We found no correlation between 25(OH)D3 levels and PTH, serum albumin, bone alkaline phosphatase, P, and Ca x P. In multiple regression analyses, the independent predictors of 25(OH)D3 were age, presence of diabetes (DM-CRF), levels of serum calcium and serum 1.25(OH)2D3. CONCLUSION: We found a high prevalence (92%) of vitamin D deficiency in these 273 PD patients, nearly one half of whom had severe vitamin D deficiency. Vitamin D deficiency is more common in DM-CRF patients than in non-DM-CRF patients. Our findings suggest that these patients should be considered for vitamin D supplementation. SN - 0301-0430 UR - https://www.unboundmedicine.com/medline/citation/17063991/Severe_vitamin_D_deficiency_in_chronic_renal_failure_patients_on_peritoneal_dialysis_ L2 - https://ClinicalTrials.gov/search/term=17063991 [PUBMED-IDS] DB - PRIME DP - Unbound Medicine ER -