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BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways.
Development. 2006 Dec; 133(23):4667-78.D

Abstract

Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture studies have provided a number of essential insights, including the demonstration that BMP pathways are required for chondrocyte proliferation and differentiation. However, limb-culture studies have yielded contradictory results; some studies indicate that BMPs exert stimulatory effects on differentiation, whereas others support inhibitory effects. Therefore, we characterized the skeletal phenotypes of mice lacking Bmpr1a in chondrocytes (Bmpr1a(CKO)) and Bmpr1a(CKO);Bmpr1b+/- (Bmpr1a(CKO);1b+/-) in order to test the roles of BMP pathways in the growth plate in vivo. These mice reveal requirements for BMP signaling in multiple aspects of chondrogenesis. They also demonstrate that the balance between signaling outputs from BMP and fibroblast growth factor (FGF) pathways plays a crucial role in the growth plate. These studies indicate that BMP signaling is required to promote Ihh expression, and to inhibit activation of STAT and ERK1/2 MAPK, key effectors of FGF signaling. BMP pathways inhibit FGF signaling, at least in part, by inhibiting the expression of FGFR1. These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways.

Authors+Show Affiliations

Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17065231

Citation

Yoon, Byeong S., et al. "BMPs Regulate Multiple Aspects of Growth-plate Chondrogenesis Through Opposing Actions On FGF Pathways." Development (Cambridge, England), vol. 133, no. 23, 2006, pp. 4667-78.
Yoon BS, Pogue R, Ovchinnikov DA, et al. BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development. 2006;133(23):4667-78.
Yoon, B. S., Pogue, R., Ovchinnikov, D. A., Yoshii, I., Mishina, Y., Behringer, R. R., & Lyons, K. M. (2006). BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. Development (Cambridge, England), 133(23), 4667-78.
Yoon BS, et al. BMPs Regulate Multiple Aspects of Growth-plate Chondrogenesis Through Opposing Actions On FGF Pathways. Development. 2006;133(23):4667-78. PubMed PMID: 17065231.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BMPs regulate multiple aspects of growth-plate chondrogenesis through opposing actions on FGF pathways. AU - Yoon,Byeong S, AU - Pogue,Robert, AU - Ovchinnikov,Dmitri A, AU - Yoshii,Isaac, AU - Mishina,Yuji, AU - Behringer,Richard R, AU - Lyons,Karen M, Y1 - 2006/10/25/ PY - 2006/10/27/pubmed PY - 2007/2/10/medline PY - 2006/10/27/entrez SP - 4667 EP - 78 JF - Development (Cambridge, England) JO - Development VL - 133 IS - 23 N2 - Bone morphogenetic protein (BMP) signaling pathways are essential regulators of chondrogenesis. However, the roles of these pathways in vivo are not well understood. Limb-culture studies have provided a number of essential insights, including the demonstration that BMP pathways are required for chondrocyte proliferation and differentiation. However, limb-culture studies have yielded contradictory results; some studies indicate that BMPs exert stimulatory effects on differentiation, whereas others support inhibitory effects. Therefore, we characterized the skeletal phenotypes of mice lacking Bmpr1a in chondrocytes (Bmpr1a(CKO)) and Bmpr1a(CKO);Bmpr1b+/- (Bmpr1a(CKO);1b+/-) in order to test the roles of BMP pathways in the growth plate in vivo. These mice reveal requirements for BMP signaling in multiple aspects of chondrogenesis. They also demonstrate that the balance between signaling outputs from BMP and fibroblast growth factor (FGF) pathways plays a crucial role in the growth plate. These studies indicate that BMP signaling is required to promote Ihh expression, and to inhibit activation of STAT and ERK1/2 MAPK, key effectors of FGF signaling. BMP pathways inhibit FGF signaling, at least in part, by inhibiting the expression of FGFR1. These results provide a genetic in vivo demonstration that the progression of chondrocytes through the growth plate is controlled by antagonistic BMP and FGF signaling pathways. SN - 0950-1991 UR - https://www.unboundmedicine.com/medline/citation/17065231/BMPs_regulate_multiple_aspects_of_growth_plate_chondrogenesis_through_opposing_actions_on_FGF_pathways_ L2 - http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=17065231 DB - PRIME DP - Unbound Medicine ER -