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Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents.
Diabetes Care 2006; 29(11):2483-8DC

Abstract

OBJECTIVE

Earlier studies suggest that children with type 1 diabetes are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent type 1 diabetes in individuals with celiac disease. We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population-based cohort.

RESEARCH DESIGN AND METHODS

We identified 9,243 children with a diagnosis of celiac disease in the Swedish national inpatient register between 1964 and 2003. We then identified five reference individuals matched at time of diagnosis for age, calendar year, sex, and county (n = 45,680). Only individuals with >1 year of follow-up after study entry (diagnosis of celiac disease) were included in the analyses.

RESULTS

Celiac disease was associated with a statistically significantly increased risk of subsequent type 1 diabetes before age 20 years (hazard ratio 2.4 [95% CI 1.9-3.0], P < 0.001). This risk increase was seen regardless of whether celiac disease was first diagnosed between 0 and 2 (2.2 [1.7-2.9], P < 0.001) or 3 and 20 (3.4 [1.9-6.1], P < 0.001) years of age. Individuals with prior celiac disease were also at increased risk of ketoacidosis or diabetic coma before the age of 20 years (2.3 [1.4-3.9], P = 0.001).

CONCLUSIONS

Children with celiac disease are at increased risk of subsequent type 1 diabetes. This risk increase is low considering that 95% of individuals with celiac disease are HLA-DQ2 positive.

Authors+Show Affiliations

Department of Pediatrics, Orebro University Hospital, Orebro 701 85, Sweden. jonasludvigsson@yahoo.com

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17065689

Citation

Ludvigsson, Jonas F., et al. "Celiac Disease and Risk of Subsequent Type 1 Diabetes: a General Population Cohort Study of Children and Adolescents." Diabetes Care, vol. 29, no. 11, 2006, pp. 2483-8.
Ludvigsson JF, Ludvigsson J, Ekbom A, et al. Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents. Diabetes Care. 2006;29(11):2483-8.
Ludvigsson, J. F., Ludvigsson, J., Ekbom, A., & Montgomery, S. M. (2006). Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents. Diabetes Care, 29(11), pp. 2483-8.
Ludvigsson JF, et al. Celiac Disease and Risk of Subsequent Type 1 Diabetes: a General Population Cohort Study of Children and Adolescents. Diabetes Care. 2006;29(11):2483-8. PubMed PMID: 17065689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Celiac disease and risk of subsequent type 1 diabetes: a general population cohort study of children and adolescents. AU - Ludvigsson,Jonas F, AU - Ludvigsson,Johnny, AU - Ekbom,Anders, AU - Montgomery,Scott M, PY - 2006/10/27/pubmed PY - 2006/12/16/medline PY - 2006/10/27/entrez SP - 2483 EP - 8 JF - Diabetes care JO - Diabetes Care VL - 29 IS - 11 N2 - OBJECTIVE: Earlier studies suggest that children with type 1 diabetes are more likely to have a subsequent diagnosis of celiac disease. However, research is sparse on the risk of subsequent type 1 diabetes in individuals with celiac disease. We sought to determine the risk of subsequent type 1 diabetes diagnosed before the age of 20 years in children and adolescents with celiac disease in a national, general population-based cohort. RESEARCH DESIGN AND METHODS: We identified 9,243 children with a diagnosis of celiac disease in the Swedish national inpatient register between 1964 and 2003. We then identified five reference individuals matched at time of diagnosis for age, calendar year, sex, and county (n = 45,680). Only individuals with >1 year of follow-up after study entry (diagnosis of celiac disease) were included in the analyses. RESULTS: Celiac disease was associated with a statistically significantly increased risk of subsequent type 1 diabetes before age 20 years (hazard ratio 2.4 [95% CI 1.9-3.0], P < 0.001). This risk increase was seen regardless of whether celiac disease was first diagnosed between 0 and 2 (2.2 [1.7-2.9], P < 0.001) or 3 and 20 (3.4 [1.9-6.1], P < 0.001) years of age. Individuals with prior celiac disease were also at increased risk of ketoacidosis or diabetic coma before the age of 20 years (2.3 [1.4-3.9], P = 0.001). CONCLUSIONS: Children with celiac disease are at increased risk of subsequent type 1 diabetes. This risk increase is low considering that 95% of individuals with celiac disease are HLA-DQ2 positive. SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/17065689/Celiac_disease_and_risk_of_subsequent_type_1_diabetes:_a_general_population_cohort_study_of_children_and_adolescents_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17065689 DB - PRIME DP - Unbound Medicine ER -