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Multiple subtypes of glycine-immunoreactive neurons in the goldfish retina: single- and double-label studies.
Vis Neurosci 1990; 4(3):299-309VN

Abstract

The glycinergic system in goldfish retina was studied by immunocytochemical localization of glycine antiserum at the light-microscopical level. Numerous amacrine cells, a type of interplexiform cell, interstitial cell, and displaced amacrine cell were glycine-immunoreactive (IR). Amacrine cells, accounting for 97% of the glycine-IR neurons, were of four types based solely on their level of dendritic stratification: stratified amacrine cells of the first, third, and fifth sublayers and bistratified amacrine cells of the first and fifth sublayers. Double-labeling experiments were carried out to determine possible co-localization of glycine-IR with GABA-IR, serotonin-IR, substance P-IR and somatostatin-IR. No evidence for co-localization of glycine-IR with these other transmitter substances was found, despite reports of co-localization of these substances in retinas of other species. Glycinergic neurons in goldfish retina appear to consist of a heterogeneous population of at least seven morphologically distinct subtypes that are also neurochemically distinct in regard to GABA, serotonin, substance P, and somatostatin. Since dendritic stratification in the inner plexiform layer is correlated with ON-, OFF-response types, we suggest that the subtypes of glycine-IR amacrine cells play different roles in the encoding of visual information.

Authors+Show Affiliations

Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

1706619

Citation

Yazulla, S, and K M. Studholme. "Multiple Subtypes of Glycine-immunoreactive Neurons in the Goldfish Retina: Single- and Double-label Studies." Visual Neuroscience, vol. 4, no. 3, 1990, pp. 299-309.
Yazulla S, Studholme KM. Multiple subtypes of glycine-immunoreactive neurons in the goldfish retina: single- and double-label studies. Vis Neurosci. 1990;4(3):299-309.
Yazulla, S., & Studholme, K. M. (1990). Multiple subtypes of glycine-immunoreactive neurons in the goldfish retina: single- and double-label studies. Visual Neuroscience, 4(3), pp. 299-309.
Yazulla S, Studholme KM. Multiple Subtypes of Glycine-immunoreactive Neurons in the Goldfish Retina: Single- and Double-label Studies. Vis Neurosci. 1990;4(3):299-309. PubMed PMID: 1706619.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multiple subtypes of glycine-immunoreactive neurons in the goldfish retina: single- and double-label studies. AU - Yazulla,S, AU - Studholme,K M, PY - 1990/3/1/pubmed PY - 1990/3/1/medline PY - 1990/3/1/entrez SP - 299 EP - 309 JF - Visual neuroscience JO - Vis. Neurosci. VL - 4 IS - 3 N2 - The glycinergic system in goldfish retina was studied by immunocytochemical localization of glycine antiserum at the light-microscopical level. Numerous amacrine cells, a type of interplexiform cell, interstitial cell, and displaced amacrine cell were glycine-immunoreactive (IR). Amacrine cells, accounting for 97% of the glycine-IR neurons, were of four types based solely on their level of dendritic stratification: stratified amacrine cells of the first, third, and fifth sublayers and bistratified amacrine cells of the first and fifth sublayers. Double-labeling experiments were carried out to determine possible co-localization of glycine-IR with GABA-IR, serotonin-IR, substance P-IR and somatostatin-IR. No evidence for co-localization of glycine-IR with these other transmitter substances was found, despite reports of co-localization of these substances in retinas of other species. Glycinergic neurons in goldfish retina appear to consist of a heterogeneous population of at least seven morphologically distinct subtypes that are also neurochemically distinct in regard to GABA, serotonin, substance P, and somatostatin. Since dendritic stratification in the inner plexiform layer is correlated with ON-, OFF-response types, we suggest that the subtypes of glycine-IR amacrine cells play different roles in the encoding of visual information. SN - 0952-5238 UR - https://www.unboundmedicine.com/medline/citation/1706619/Multiple_subtypes_of_glycine_immunoreactive_neurons_in_the_goldfish_retina:_single__and_double_label_studies_ DB - PRIME DP - Unbound Medicine ER -