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Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice.
Eur J Neurosci. 2006 Oct; 24(7):1874-84.EJ

Abstract

The aetiology of idiopathic Parkinson's disease (PD) is poorly defined but environmental aggression may be relevant. Here, we report a new model of PD in mice, based on chronic inoculation with neurotoxins in the nasal cavity, which is a natural route of contact with the environment. C57BL/6 mice, submitted to daily intranasal inoculation with MPTP for 30 days, developed motor deficits that correlated with a progressive and severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase and dopamine transporter staining in substantia nigra and striatum. Moreover, mice intranasally inoculated with MPTP developed strong astrogliosis and microgliosis in substantia nigra and striatum. Consistent with these observations, a role for oxidant aggression was demonstrated by increased levels of Mn-superoxide dismutase. However, alpha-synuclein aggregation was not observed. This new animal model provides a new tool for studying PD symptoms that develop slowly over time, and it may be used to asses risk from environmental neurotoxins.

Authors+Show Affiliations

Instituto de Investigaciones Biomédicas and Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid, Arzobispo Morcillo 4, 28029 Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17067291

Citation

Rojo, Ana I., et al. "Persistent Penetration of MPTP Through the Nasal Route Induces Parkinson's Disease in Mice." The European Journal of Neuroscience, vol. 24, no. 7, 2006, pp. 1874-84.
Rojo AI, Montero C, Salazar M, et al. Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. Eur J Neurosci. 2006;24(7):1874-84.
Rojo, A. I., Montero, C., Salazar, M., Close, R. M., Fernández-Ruiz, J., Sánchez-González, M. A., de Sagarra, M. R., Jackson-Lewis, V., Cavada, C., & Cuadrado, A. (2006). Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. The European Journal of Neuroscience, 24(7), 1874-84.
Rojo AI, et al. Persistent Penetration of MPTP Through the Nasal Route Induces Parkinson's Disease in Mice. Eur J Neurosci. 2006;24(7):1874-84. PubMed PMID: 17067291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Persistent penetration of MPTP through the nasal route induces Parkinson's disease in mice. AU - Rojo,Ana I, AU - Montero,Celia, AU - Salazar,María, AU - Close,Ryan M, AU - Fernández-Ruiz,Javier, AU - Sánchez-González,Miguel A, AU - de Sagarra,María Rosa, AU - Jackson-Lewis,Vernice, AU - Cavada,Carmen, AU - Cuadrado,Antonio, PY - 2006/10/28/pubmed PY - 2006/12/22/medline PY - 2006/10/28/entrez SP - 1874 EP - 84 JF - The European journal of neuroscience JO - Eur J Neurosci VL - 24 IS - 7 N2 - The aetiology of idiopathic Parkinson's disease (PD) is poorly defined but environmental aggression may be relevant. Here, we report a new model of PD in mice, based on chronic inoculation with neurotoxins in the nasal cavity, which is a natural route of contact with the environment. C57BL/6 mice, submitted to daily intranasal inoculation with MPTP for 30 days, developed motor deficits that correlated with a progressive and severe depletion of striatal dopamine levels, and loss of tyrosine hydroxylase and dopamine transporter staining in substantia nigra and striatum. Moreover, mice intranasally inoculated with MPTP developed strong astrogliosis and microgliosis in substantia nigra and striatum. Consistent with these observations, a role for oxidant aggression was demonstrated by increased levels of Mn-superoxide dismutase. However, alpha-synuclein aggregation was not observed. This new animal model provides a new tool for studying PD symptoms that develop slowly over time, and it may be used to asses risk from environmental neurotoxins. SN - 0953-816X UR - https://www.unboundmedicine.com/medline/citation/17067291/Persistent_penetration_of_MPTP_through_the_nasal_route_induces_Parkinson's_disease_in_mice_ DB - PRIME DP - Unbound Medicine ER -