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[Effects of different methods of anesthesia and analgesia on early postoperative cognitive dysfunction after non-cardiac surgery in the elderly].
Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Oct 18; 38(5):510-4.BD

Abstract

OBJECTIVE

To determine if different methods of anesthesia and analgesia will influence the incidence of early postoperative cognitive dysfunction (POCD) after non-cardiac surgery in the elderly.

METHODS

One hundred and three elderly patients undergoing elective abdominal surgery were randomly allocated to receive either general anesthesia followed with postoperative intravenous analgesia (general anesthesia group, 53 cases) or combined general-epidural anesthesia followed with postoperative epidural analgesia (combined general-epidural anesthesia group, 50 cases). Cognitive function was assessed preoperatively and 7 days postoperatively using a battery of nine neuropsychological tests. A postoperative deficit in any test was defined when decline by more than or equal to 20% of the preoperative value of that test occurred. Any patient showing deficit in 2 or more tests was defined as having postoperative cognitive dysfunction.

RESULTS

Ninety-two patients completed both preoperative and postoperative neuropsychological tests. On day 7, POCD occurred in 20/45 patients (44.4%) in the general anesthesia group and in 23/47 patients (48.9%) in the combined general-epidural anesthesia group. No significant difference was found between the two groups. Logistic regression analysis showed that short duration of education and operation of general surgery were independent risk factors of the occurrence of early POCD.

CONCLUSION

Early POCD occurred in 46.7% of the elderly patients undergoing abdominal surgery. However, there was no significant difference between the effects of two different methods of anesthesia and postoperative analgesia on the incidence of POCD. Short duration of education and operation of general surgery were risk factors of early POCD.

Authors+Show Affiliations

Department of Anesthesiology, Peking University First Hospital, Beijing 100034, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

17068625

Citation

Pan, Li-feng, et al. "[Effects of Different Methods of Anesthesia and Analgesia On Early Postoperative Cognitive Dysfunction After Non-cardiac Surgery in the Elderly]." Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, vol. 38, no. 5, 2006, pp. 510-4.
Pan LF, Wang DX, Li J. [Effects of different methods of anesthesia and analgesia on early postoperative cognitive dysfunction after non-cardiac surgery in the elderly]. Beijing Da Xue Xue Bao Yi Xue Ban. 2006;38(5):510-4.
Pan, L. F., Wang, D. X., & Li, J. (2006). [Effects of different methods of anesthesia and analgesia on early postoperative cognitive dysfunction after non-cardiac surgery in the elderly]. Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences, 38(5), 510-4.
Pan LF, Wang DX, Li J. [Effects of Different Methods of Anesthesia and Analgesia On Early Postoperative Cognitive Dysfunction After Non-cardiac Surgery in the Elderly]. Beijing Da Xue Xue Bao Yi Xue Ban. 2006 Oct 18;38(5):510-4. PubMed PMID: 17068625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effects of different methods of anesthesia and analgesia on early postoperative cognitive dysfunction after non-cardiac surgery in the elderly]. AU - Pan,Li-feng, AU - Wang,Dong-xin, AU - Li,Jun, PY - 2006/10/28/pubmed PY - 2008/5/28/medline PY - 2006/10/28/entrez SP - 510 EP - 4 JF - Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences JO - Beijing Da Xue Xue Bao Yi Xue Ban VL - 38 IS - 5 N2 - OBJECTIVE: To determine if different methods of anesthesia and analgesia will influence the incidence of early postoperative cognitive dysfunction (POCD) after non-cardiac surgery in the elderly. METHODS: One hundred and three elderly patients undergoing elective abdominal surgery were randomly allocated to receive either general anesthesia followed with postoperative intravenous analgesia (general anesthesia group, 53 cases) or combined general-epidural anesthesia followed with postoperative epidural analgesia (combined general-epidural anesthesia group, 50 cases). Cognitive function was assessed preoperatively and 7 days postoperatively using a battery of nine neuropsychological tests. A postoperative deficit in any test was defined when decline by more than or equal to 20% of the preoperative value of that test occurred. Any patient showing deficit in 2 or more tests was defined as having postoperative cognitive dysfunction. RESULTS: Ninety-two patients completed both preoperative and postoperative neuropsychological tests. On day 7, POCD occurred in 20/45 patients (44.4%) in the general anesthesia group and in 23/47 patients (48.9%) in the combined general-epidural anesthesia group. No significant difference was found between the two groups. Logistic regression analysis showed that short duration of education and operation of general surgery were independent risk factors of the occurrence of early POCD. CONCLUSION: Early POCD occurred in 46.7% of the elderly patients undergoing abdominal surgery. However, there was no significant difference between the effects of two different methods of anesthesia and postoperative analgesia on the incidence of POCD. Short duration of education and operation of general surgery were risk factors of early POCD. SN - 1671-167X UR - https://www.unboundmedicine.com/medline/citation/17068625/[Effects_of_different_methods_of_anesthesia_and_analgesia_on_early_postoperative_cognitive_dysfunction_after_non_cardiac_surgery_in_the_elderly]_ L2 - http://xuebao.bjmu.edu.cn/EN/Y2006/V38/I5/510 DB - PRIME DP - Unbound Medicine ER -