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[Antihaemostatic strategies or renal replacement therapies in acute renal failure].
G Ital Nefrol. 2006 May-Jun; 23 Suppl 36:S120-6.GI

Abstract

Critically ill patients with acute renal failure, and especially those with sepsis, may have increased coagulation changes as well as a high incidence of hemorrhagic complications. Thus, in this clinical condition, the use of renal replacement therapies (RRT) can be frequently complicated both by high rates of extracorporeal circuit coagulation, resulting in a reduced treatment efficacy, and by increased incidence of bleeding. Heparin is the most commonly used RRT anticoagulant, even if several alternative options have been proposed, aiming at obtaining regional anticoagulation (i.e., limited to the extracorporeal circuit). This review analyses modern strategies for RRT anticoagulation and evaluates safety and efficacy parameters of each method. In this regard, no definite recommendations can be made based on the available evidence further randomised controlled trials are needed in this field, with a clear endpoint definition.

Authors+Show Affiliations

Fiaccadori E
Dipartimento di Clinica Medica, Nefrologia e Scienze della Prevenzione, Università degli Studi, Parma. fiaccadori@unipr.it
Rotelli C
No affiliation info available
Parenti E
No affiliation info available
Giacosa R
No affiliation info available
Picetti E
No affiliation info available
Antonucci E
No affiliation info available
Maggiore U
No affiliation info available
Cabassi A
No affiliation info available

MeSH

Acute Kidney InjuryAnticoagulantsBlood Coagulation DisordersHemorrhageHeparinHumansRenal Replacement Therapy

Pub Type(s)

English Abstract
Journal Article
Review

Language

ita

PubMed ID

17068739

Citation

Fiaccadori, E, et al. "[Antihaemostatic Strategies or Renal Replacement Therapies in Acute Renal Failure]." Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia, vol. 23 Suppl 36, 2006, pp. S120-6.
Fiaccadori E, Rotelli C, Parenti E, et al. [Antihaemostatic strategies or renal replacement therapies in acute renal failure]. G Ital Nefrol. 2006;23 Suppl 36:S120-6.
Fiaccadori, E., Rotelli, C., Parenti, E., Giacosa, R., Picetti, E., Antonucci, E., Maggiore, U., & Cabassi, A. (2006). [Antihaemostatic strategies or renal replacement therapies in acute renal failure]. Giornale Italiano Di Nefrologia : Organo Ufficiale Della Societa Italiana Di Nefrologia, 23 Suppl 36, S120-6.
Fiaccadori E, et al. [Antihaemostatic Strategies or Renal Replacement Therapies in Acute Renal Failure]. G Ital Nefrol. 2006;23 Suppl 36:S120-6. PubMed PMID: 17068739.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Antihaemostatic strategies or renal replacement therapies in acute renal failure]. AU - Fiaccadori,E, AU - Rotelli,C, AU - Parenti,E, AU - Giacosa,R, AU - Picetti,E, AU - Antonucci,E, AU - Maggiore,U, AU - Cabassi,A, PY - 2006/10/28/pubmed PY - 2008/3/14/medline PY - 2006/10/28/entrez SP - S120 EP - 6 JF - Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia JO - G Ital Nefrol VL - 23 Suppl 36 N2 - Critically ill patients with acute renal failure, and especially those with sepsis, may have increased coagulation changes as well as a high incidence of hemorrhagic complications. Thus, in this clinical condition, the use of renal replacement therapies (RRT) can be frequently complicated both by high rates of extracorporeal circuit coagulation, resulting in a reduced treatment efficacy, and by increased incidence of bleeding. Heparin is the most commonly used RRT anticoagulant, even if several alternative options have been proposed, aiming at obtaining regional anticoagulation (i.e., limited to the extracorporeal circuit). This review analyses modern strategies for RRT anticoagulation and evaluates safety and efficacy parameters of each method. In this regard, no definite recommendations can be made based on the available evidence further randomised controlled trials are needed in this field, with a clear endpoint definition. SN - 0393-5590 UR - https://www.unboundmedicine.com/medline/citation/17068739/[Antihaemostatic_strategies_or_renal_replacement_therapies_in_acute_renal_failure]_ DB - PRIME DP - Unbound Medicine ER -